Protein Alignment Cdk5 and Cdkl2

DIOPT Version :10

• Sequence 1: NP_477080.1
• Gene: Cdk5 / 36727
• FlyBaseID: FBgn0013762
• Length: 294
• Species: Drosophila melanogaster
• Sequence 2: NP_058608.1
• Gene: Cdkl2 / 53886
• MGIID: 1858227
• Length: 568
• Species: Mus musculus
• Alignment Length: 301
• Identity: 112/301 - (37%)
• Similarity: 171/301 - (56%)
• Gaps: 27/301 - (8%)

  Fly     1 MQKYDKMEKIGEGTYGTVFKGRNRDTMEIVALKRVRLDEDDEGVPSSALREICLLKELKHKNIVR 65
            |:||:.:..:|||:||.|.|.||:|:..|||:|:....:||:.|...|:|||.|||:|:|:|:|.
Mouse     1 MEKYENLGLVGEGSYGMVMKCRNKDSGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENLVN 65

  Fly    66 LIDVLHSDKKLTLVFEHCD----QDLKKYFDSLNGEIDMAVCRSFMLQLLRGLAFCHSHNVLHRD 126
            |::|....|:..||||..|    .|||.:   .|| :|..|.:.::.|::.|:.||||||::|||
Mouse    66 LLEVCKKKKRWYLVFEFVDHTILDDLKLF---PNG-LDYQVVQKYLFQIINGIGFCHSHNIIHRD 126

  Fly   127 LKPQNLLINKNGELKLADFGLARAFGIPVKCYSAEVVTLWYRPPDVLFGAKLYTTSIDMWSAGCI 191
            :||:|:|::::|.:||.|||.||....|.:.|:..|.|.|||.|::|.|...|..::|:|:.||:
Mouse   127 IKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDIWAIGCL 191

  Fly   192 LAELADAGRPLFPGSDVLDQLMKIFRVLGT--PNEDS-------WPGV--SHLSDYVALPSFPAI 245
            :.|:. .|:|||||...:|||..|...||.  |....       :.||  ..:.|..|.|
Mouse   192 VIEML-MGQPLFPGESDIDQLHHIMTCLGNLIPRHQELFYKNPVFAGVRLPEVKDAEAEP----- 250

  Fly   246 TSWSQLVPRLNSKGRDLLQKLLICRPNQRISAEAAMQHPYF 286
              .....|:|......|.:|.|...|::|......::|.:|
Mouse   251 --LESRYPKLPEAVISLAKKCLHIDPDKRPFCADLLRHDFF 289

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk5	NP_477080.1	STKc_CDK5	3..286	CDD:143344	110/297 (37%)
Cdkl2	NP_058608.1	STKc_CDKL2_3	2..289	CDD:270836	110/298 (37%)
		[NKR]KIAxRE	45..51		1/5 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	309..333
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	545..568