Protein Alignment Cdk5 and CDKL3

DIOPT Version :10

• Sequence 1: NP_477080.1
• Gene: Cdk5 / 36727
• FlyBaseID: FBgn0013762
• Length: 294
• Species: Drosophila melanogaster
• Sequence 2: XP_011541731.1
• Gene: CDKL3 / 51265
• HGNCID: 15483
• Length: 619
• Species: Homo sapiens
• Alignment Length: 305
• Identity: 106/305 - (34%)
• Similarity: 166/305 - (54%)
• Gaps: 24/305 - (7%)

  Fly     1 MQKYDKMEKIGEGTYGTVFKGRNRDTMEIVALKRVRLDEDDEGVPSSALREICLLKELKHKNIVR 65
            |:.|:.:.|:|||:||||.|.::::|.:|||:| :..:..::.|...|:|||..||:..|:|:|.
Human     1 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIK-IFYERPEQSVNKIAMREIKFLKQFHHENLVN 64

  Fly    66 LIDVLHSDKKLTLVFEHCD----QDLKKYFDSLNGEIDMAVCRSFMLQLLRGLAFCHSHNVLHRD 126
            ||:|....||:.||||..|    .:|:.|...|..:    ..|.::.|:||.:.:.||:|::|||
Human    65 LIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESK----RLRKYLFQILRAIDYLHSNNIIHRD 125

  Fly   127 LKPQNLLINKNGELKLADFGLARAFGIPVKCYSAEVVTLWYRPPD-----------VLFG-AKLY 179
            :||:|:|::::|..||.|||.||....|...|:..|.|.|||.|:           |.|| ...:
Human   126 IKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYGKYVYFGILSAF 190

  Fly   180 TTSIDMWSAGCILAELADAGRPLFPGSDVLDQLMKIFRVLG--TPNEDSWPGVSHLSDYVALPSF 242
            ...:|:|:.||::.|:| .|.|..|.|..||.|.||...:|  :|:..:....|.:...|.||..
Human   191 PRPVDIWALGCMIIEMA-TGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVLPQV 254

  Fly   243 PAITSWSQLVPRLNSKGRDLLQKLLICRPNQRISAEAAMQHPYFT 287
            ....:..:..|:||....|::...|...|..|||:...:.|.|||
Human   255 QHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFT 299

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk5	NP_477080.1	STKc_CDK5	3..286	CDD:143344	102/300 (34%)
CDKL3	XP_011541731.1	STKc_CDKL2_3	2..298	CDD:270836	102/301 (34%)