Protein Alignment Cdk5 and Cdkl4

DIOPT Version :10

• Sequence 1: NP_477080.1
• Gene: Cdk5 / 36727
• FlyBaseID: FBgn0013762
• Length: 294
• Species: Drosophila melanogaster
• Sequence 2: NP_001419046.1
• Gene: Cdkl4 / 503009
• RGDID: 1583704
• Length: 342
• Species: Rattus norvegicus
• Alignment Length: 288
• Identity: 112/288 - (38%)
• Similarity: 166/288 - (57%)
• Gaps: 4/288 - (1%)

  Fly     1 MQKYDKMEKIGEGTYGTVFKGRNRDTMEIVALKRVRLDEDDEGVPSSALREICLLKELKHKNIVR 65
            |:||:|:.|||||:||.|||.||:.:.::||:|:....|||..|...|||||.:||:|||.|:|.
  Rat     1 MEKYEKLAKIGEGSYGVVFKCRNKSSGQVVAIKKFVESEDDPVVRKIALREIRMLKQLKHPNLVN 65

  Fly    66 LIDVLHSDKKLTLVFEHCDQDLKKYFDSLNGEIDMAVCRSFMLQLLRGLAFCHSHNVLHRDLKPQ 130
            ||:|....:|:.||||:||..|....:.....:...|.:|.:.|.|:.|.|||.||.:|||:||:
  Rat    66 LIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVSDGVIKSVLWQTLQALNFCHKHNCIHRDVKPE 130

  Fly   131 NLLINKNGELKLADFGLARAFGIPVKCYSAEVVTLWYRPPDVLFGAKLYTTSIDMWSAGCILAEL 195
            |:||.|.|.:|:.|||.||.. ||...|:..|.|.|||.|::|.|...|.:|:|:|:.||:.|||
  Rat   131 NILIAKQGVIKICDFGFARIL-IPGDAYTDYVATRWYRAPELLVGDTKYGSSVDIWAVGCVFAEL 194

  Fly   196 ADAGRPLFPGSDVLDQLMKIFRVLG--TPNEDSWPGVSHLSDYVALPSFPAITSWSQLVPRLNSK 258
            . .|:||:||...:|||..|.|.||  .|...|....:.....:::|....:.:..:....:...
  Rat   195 L-TGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKSNQFFRGISIPEPEDMETLEEKFSNVQPM 258

  Fly   259 GRDLLQKLLICRPNQRISAEAAMQHPYF 286
            ....::..|...|::|::....:...||
  Rat   259 ALSFMKGCLKMDPDERLTCAQLLDSTYF 286

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk5	NP_477080.1	STKc_CDK5	3..286	CDD:143344	109/284 (38%)
Cdkl4	NP_001419046.1	STKc_CDKL1_4	2..286	CDD:270837	109/285 (38%)