Protein Alignment Cdk5 and Mapk12

DIOPT Version :10

• Sequence 1: NP_477080.1
• Gene: Cdk5 / 36727
• FlyBaseID: FBgn0013762
• Length: 294
• Species: Drosophila melanogaster
• Sequence 2: XP_006521121.1
• Gene: Mapk12 / 29857
• MGIID: 1353438
• Length: 390
• Species: Mus musculus
• Alignment Length: 318
• Identity: 105/318 - (33%)
• Similarity: 164/318 - (51%)
• Gaps: 45/318 - (14%)

  Fly     4 YDKMEKIGEGTYGTVFKGRNRDTMEIVALKRVRLDEDDEGVPSSALREICLLKELKHKNIVRLID 68
            |..::.:|.|.||.|....:..|...||:|::......|.....|.||:.|||.::|:|::.|:|
Mouse    27 YQDLQPVGSGAYGAVCSAVDSRTGNKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLD 91

  Fly    69 VLHSDKKLT------LVFEHCDQDLKKYF--DSLNGE-IDMAVCRSFMLQLLRGLAFCHSHNVLH 124
            |...|:.|.      ||......||.|..  ::|:.: |...|     .|:|:||.:.|:..|:|
Mouse    92 VFTPDESLDDFTDFYLVMPFMGTDLGKLMKHETLSEDRIQFLV-----YQMLKGLKYIHAAGVIH 151

  Fly   125 RDLKPQNLLINKNGELKLADFGLARAFGIPVKCYSAEVVTLWYRPPDVLFGAKLYTTSIDMWSAG 189
            |||||.||.:|::.|||:.||||||.....:..|   |||.|||.|:|:.....||.::|:||.|
Mouse   152 RDLKPGNLAVNEDCELKILDFGLARQADSEMTGY---VVTRWYRAPEVILNWMRYTQTVDIWSVG 213

  Fly   190 CILAELADAGRPLFPGSDVLDQLMKIFRVLGTPNEDS--------------WPGV---------- 230
            ||:||:. .|:.||.|:|.||||.:|.::.|||..:.              |.|:
Mouse   214 CIMAEMI-TGKILFKGNDHLDQLKEIMKITGTPPPEFVQKLQSAEVSGSGWWAGLGLGGWPITLF 277

  Fly   231 -SHLSDYV-ALPSFPAITSWSQLVPRLNSKGRDLLQKLLICRPNQRISAEAAMQHPYF 286
             |...:|: .||.... ..::.::...:.:..:||:::|:....||::|..|:.||||
Mouse   278 PSQAKNYMEGLPELEK-KDFASVLTNASPQAVNLLERMLVLDAEQRVTAAEALTHPYF 334

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk5	NP_477080.1	STKc_CDK5	3..286	CDD:143344	103/316 (33%)
Mapk12	XP_006521121.1	STKc_p38gamma	11..376	CDD:143385	105/318 (33%)