Protein Alignment Cdk5 and cdk-12

DIOPT Version :10

• Sequence 1: NP_477080.1
• Gene: Cdk5 / 36727
• FlyBaseID: FBgn0013762
• Length: 294
• Species: Drosophila melanogaster
• Sequence 2: NP_001367220.1
• Gene: cdk-12 / 175559
• WormBaseID: WBGene00007135
• Length: 734
• Species: Caenorhabditis elegans
• Alignment Length: 306
• Identity: 129/306 - (42%)
• Similarity: 183/306 - (59%)
• Gaps: 36/306 - (11%)

  Fly     4 YDKMEKIGEGTYGTVFKGRNRDTMEIVALKRVRLDEDDEGVPSSALREICLLKELKHKNIVRLID 68
            |..:::|||||||.|:|..|..|.|.||||||||:.:.||.|.:|:|||.:|::|.|||||||:|
 Worm   311 YTMLDQIGEGTYGQVYKAVNNLTGEQVALKRVRLENEKEGFPITAIREIKILRQLHHKNIVRLMD 375

  Fly    69 VLHSDKKLT----------LVFEHCDQDL------KKYFDSLNGEIDMAVCRSFMLQLLRGLAFC 117
            ::..|..:.          ||||:.|.||      |:..|....:|    | |...|||.|||:.
 Worm   376 IVIDDISMDELKRTRANFYLVFEYVDHDLIGLLESKELVDFNKDQI----C-SLFKQLLEGLAYI 435

  Fly   118 HSHNVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVKCYSAEVVTLWYRPPDVLFGAKLYTTS 182
            |:...||||:|..|:|:|..||||:||.||||.:....:.|:..|:|||||||::|.|.:.|..:
 Worm   436 HNTGFLHRDIKCSNILVNNKGELKIADLGLARLWEKESRLYTNRVITLWYRPPELLLGDERYGPA 500

  Fly   183 IDMWSAGCILAELADAGRPLFPGSDVLDQLMKIFRVLGTPNEDSWPGVSHLSDYVALPSFPAITS 247
            ||:||.||:|.||. ..:|||.|::...||..|.:|.|:||.|:||   .|::.|...:|....:
 Worm   501 IDVWSTGCMLGELF-TRKPLFNGNNEFGQLELISKVCGSPNVDNWP---ELTELVGWNTFRMKRT 561

  Fly   248 WSQ--------LVPRLNSKGRDLLQKLLICRPNQRISAEAAMQHPY 285
            :.:        ::||   :..|||.|:|...|.:||||:.|:.||:
 Worm   562 YQRRIREEFEHIMPR---EAVDLLDKMLTLNPEKRISAKEALNHPW 604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk5	NP_477080.1	STKc_CDK5	3..286	CDD:143344	129/306 (42%)
cdk-12	NP_001367220.1	STKc_CDK12	303..605	CDD:270847	129/306 (42%)