Protein Alignment Cdk5 and Cdk4

DIOPT Version :10

• Sequence 1: NP_477080.1
• Gene: Cdk5 / 36727
• FlyBaseID: FBgn0013762
• Length: 294
• Species: Drosophila melanogaster
• Sequence 2: XP_315841.3
• Gene: Cdk4 / 1276486
• VectorBaseID: AGAMI1_007178
• Length: 302
• Species: Anopheles gambiae
• Alignment Length: 298
• Identity: 123/298 - (41%)
• Similarity: 180/298 - (60%)
• Gaps: 23/298 - (7%)

  Fly     4 YDKMEKIGEGTYGTVFKGRN-RDTMEIVALKRVRLDEDDEGVPSSALREICLLKELK---HKNIV 64
            |:::..||.|.||||::.|: ::...|||||:||:...::|||.|.||||.:||:|.   |.|:|
Mosquito     6 YEELGVIGTGAYGTVYRARDLKNAGTIVALKKVRVALTEDGVPMSTLREIFMLKQLDTFGHPNVV 70

  Fly    65 RLIDVLHSDK-------KLTLVFEHCDQDLKKYFDSLNGE-IDMAVCRSFMLQLLRGLAFCHSHN 121
            :|:||....:       .|.|||||.|.||.:|...|..: :..|..:....::|.|:.|.|||.
Mosquito    71 KLLDVCQGQRLEREGQLVLFLVFEHLDHDLDEYIKRLPPKGMPPATIQRLSREMLTGIDFLHSHR 135

  Fly   122 VLHRDLKPQNLLINKNGELKLADFGLARAFGIPVKCYSAEVVTLWYRPPDVLFGAKLYTTSIDMW 186
            ::|||||||||||:.:|.|||||||||:.:...:| .:..|||||||.|:||.| :.|.:|:|:|
Mosquito   136 IIHRDLKPQNLLISSDGHLKLADFGLAKTYDFEMK-LTTVVVTLWYRAPEVLLG-EAYNSSVDIW 198

  Fly   187 SAGCILAELADAGRPLFPGSDVLDQLMKIFRVLGTPNEDSWP-GVSHLSDYVALPSFPAITSWS- 249
            |||||:||:... :.||||:...:||.:||.:.|.|:|..|| |:|     :...:|.:.....
Mosquito   199 SAGCIIAEMFQR-QALFPGTAEGNQLERIFELTGRPSEAQWPRGIS-----IVRENFRSTQRREP 257

  Fly   250 -QLVPRLNSKGRDLLQKLLICRPNQRISAEAAMQHPYF 286
             :..|:|.....|||:.:|....::|.||...:.|.||
Mosquito   258 REFCPKLCDNANDLLKSMLAFSRHERPSARQCLNHAYF 295

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk5	NP_477080.1	STKc_CDK5	3..286	CDD:143344	121/296 (41%)
Cdk4	XP_315841.3	STKc_CDK4_6_like	6..295	CDD:270831	121/296 (41%)