Protein Alignment Cdk5 and Cdk6

DIOPT Version :10

• Sequence 1: NP_477080.1
• Gene: Cdk5 / 36727
• FlyBaseID: FBgn0013762
• Length: 294
• Species: Drosophila melanogaster
• Sequence 2: NP_034003.1
• Gene: Cdk6 / 12571
• MGIID: 1277162
• Length: 326
• Species: Mus musculus
• Alignment Length: 302
• Identity: 142/302 - (47%)
• Similarity: 187/302 - (61%)
• Gaps: 25/302 - (8%)

  Fly     2 QKYDKMEKIGEGTYGTVFKGRN-RDTMEIVALKRVRLDEDDEGVPSSALREICLLKEL---KHKN 62
            |:|:.:.:||||.||.|||.|: ::....|||||||:...:||:|.|.:||:.:|:.|   :|.|
Mouse    11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTSEEGMPLSTIREVAVLRHLETFEHPN 75

  Fly    63 IVRLIDVL---HSDK--KLTLVFEHCDQDLKKYFDSL-NGEIDMAVCRSFMLQLLRGLAFCHSHN 121
            :|||.||.   .:|:  ||||||||.||||..|.|.: ...:.....:..|.||||||.|.|||.
Mouse    76 VVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHR 140

  Fly   122 VLHRDLKPQNLLINKNGELKLADFGLARAFGIPVKCYSAEVVTLWYRPPDVLFGAKLYTTSIDMW 186
            |:||||||||:|:..:|::|||||||||.:...:...|. |||||||.|:||..:. |.|.:|:|
Mouse   141 VVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSV-VVTLWYRAPEVLLQSS-YATPVDLW 203

  Fly   187 SAGCILAELADAGRPLFPGSDVLDQLMKIFRVLGTPNEDSWPGVSHLSDYVALPSFPAITSWS-- 249
            |.|||.||:. ..:|||.||..:|||.||..::|.|.|:.||     .| ||||. .|..|.|
Mouse   204 SVGCIFAEMF-RRKPLFRGSSDVDQLGKILDIIGLPGEEDWP-----RD-VALPR-QAFHSKSAQ 260

  Fly   250 ---QLVPRLNSKGRDLLQKLLICRPNQRISAEAAMQHPYFTD 288
               :.|..::..|:|||.|.|...|.:||||..|:.||||.|
Mouse   261 PIEKFVTDIDELGKDLLLKCLTFNPAKRISAYGALNHPYFQD 302

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk5	NP_477080.1	STKc_CDK5	3..286	CDD:143344	138/297 (46%)
Cdk6	NP_034003.1	STKc_CDK6	11..300	CDD:270846	139/298 (47%)