Protein Alignment Cdk5 and cdkl2

DIOPT Version :10

• Sequence 1: NP_477080.1
• Gene: Cdk5 / 36727
• FlyBaseID: FBgn0013762
• Length: 294
• Species: Drosophila melanogaster
• Sequence 2: XP_002938668.2
• Gene: cdkl2 / 100487310
• XenbaseID: XB-GENE-5959638
• Length: 565
• Species: Xenopus tropicalis
• Alignment Length: 301
• Identity: 112/301 - (37%)
• Similarity: 170/301 - (56%)
• Gaps: 17/301 - (5%)

  Fly     1 MQKYDKMEKIGEGTYGTVFKGRNRDTMEIVALKRVRLDEDDEGVPSSALREICLLKELKHKNIVR 65
            |:||:.:..:|||:||.|.|.||::...|||:|:....|||:.|...|:|||.|||:|:|:|:|.
 Frog     1 MEKYENLGLVGEGSYGMVMKCRNKENGRIVAVKKFLESEDDKMVKKIAMREIKLLKQLRHENLVN 65

  Fly    66 LIDVLHSDKKLTLVFEHCDQDLKKYFDSLNGEIDMAVCRSFMLQLLRGLAFCHSHNVLHRDLKPQ 130
            |::|....|:..||||..|:.:....:.....:|.:..|.::.|::||:.||||||::|||:||:
 Frog    66 LLEVCKKKKRWYLVFEFVDRTVLDDLEQFPNGLDFSKVRKYLFQIIRGIGFCHSHNIIHRDIKPE 130

  Fly   131 NLLINKNGELKLADFGLARAFGIPVKCYSAEVVTLWYRPPDVLFGAKLYTTSIDMWSAGCILAEL 195
            |:|::.:|.:||.|||.||....|.:.|:..|.|.|||.|::|.|...|..::|:|:.|||:.|:
 Frog   131 NILVSHSGIVKLCDFGFARTLAGPGEDYTDYVATRWYRAPELLVGDIKYGKAVDVWAIGCIVTEM 195

  Fly   196 ADAGRPLFPGSDVLDQLMKIFRVLG--TPNEDS-------WPGVSHLSDYVALPSFPAITSWSQL 251
            ..| :|||||...:|||..|.:..|  ||....       :.|.|       ||......|....
 Frog   196 LTA-QPLFPGDSDIDQLHHIVKCQGNLTPRHQELFYRNPMFAGFS-------LPDMKEAESLEWR 252

  Fly   252 VPRLNSKGRDLLQKLLICRPNQRISAEAAMQHPYFTDSSSS 292
            .|:|:....||.:..|...|::|.:....:.|..||..|.|
 Frog   253 YPKLSPIMLDLAKSCLHIDPDKRPACMTLLLHELFTKDSFS 293

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk5	NP_477080.1	STKc_CDK5	3..286	CDD:143344	107/291 (37%)
cdkl2	XP_002938668.2	STKc_CDKL2_3	2..287	CDD:270836	107/292 (37%)