DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Khc-73 and KAR3

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	NP_015467.1	Gene:	KAR3 / 856263	SGDID:	S000006345	Length:	729	Species:	Saccharomyces cerevisiae

Alignment Length:	360	Identity:	126/360 - (35%)
Similarity:	193/360 - (53%)	Gaps:	30/360 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIER-KQPKTFAFDHCFYSLNPEDEN 69
            |:|..|:||..:.....||..|...|...........:.||:. .|...|.||..|   :.:|.|
Yeast   387 IRVYCRIRPALKNLENSDTSLINVNEFDDNSGVQSMEVTKIQNTAQVHEFKFDKIF---DQQDTN 448

  Fly    70 FASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCDQLFSAIANK 134
            .    .||..||: ::.::..|||.||||||||||||::||:...:  ||||.....:|:.|...
Yeast   449 V----DVFKEVGQ-LVQSSLDGYNVCIFAYGQTGSGKTFTMLNPGD--GIIPSTISHIFNWINKL 506

  Fly   135 STPELMYKVEVSYMEIYNEKVHDLL-DPKPNKQSLKV-------REHNVMGPYVDGLSQLAVTSY 191
            .|....|||...::|||||.:.||| ....||:...:       .:.......:..::...:.|.
Yeast   507 KTKGWDYKVNCEFIEIYNENIVDLLRSDNNNKEDTSIGLKHEIRHDQETKTTTITNVTSCKLESE 571

  Fly   192 QDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSER 256
            :.::.::.:.||.|:.|:|..|..|||||::|.:.|:.  ::..||  ......::|||||||||
Yeast   572 EMVEIILKKANKLRSTASTASNEHSSRSHSIFIIHLSG--SNAKTG--AHSYGTLNLVDLAGSER 632

  Fly   257 AVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLGGNS 321
            ...:..|||||:|..||||||:.||.||..|     |:.....:.:|:|:|.||:||:.:|.|:|
Yeast   633 INVSQVVGDRLRETQNINKSLSCLGDVIHAL-----GQPDSTKRHIPFRNSKLTYLLQYSLTGDS 692

  Fly   322 RTVMVATISPSADNYEETLSTLRYADR--AKRIVN 354
            :|:|...||||:.:..|||::||:|.:  :.|:|:
Yeast   693 KTLMFVNISPSSSHINETLNSLRFASKVNSTRLVS 727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	126/360 (35%)
		KISc	6..359	CDD:214526	126/360 (35%)
		Kinesin_assoc	356..468	CDD:292801
		FHA	446..546	CDD:238017
		KIF1B	741..786	CDD:289208
		DUF3694	<1196..1252	CDD:289256
		CAP_GLY	1786..1850	CDD:279625
KAR3	NP_015467.1	Smc	98..>387	CDD:224117	126/360 (35%)
KAR3	NP_015467.1	KISc_C_terminal	384..725	CDD:276817	124/356 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910