Protein Alignment Khc-73 and KIP3

DIOPT Version :10

• Sequence 1: NP_001261000.1
• Gene: Khc-73 / 36718
• FlyBaseID: FBgn0019968
• Length: 1957
• Species: Drosophila melanogaster
• Sequence 2: NP_011299.1
• Gene: KIP3 / 852655
• SGDID: S000003184
• Length: 805
• Species: Saccharomyces cerevisiae
• Alignment Length: 845
• Identity: 231/845 - (27%)
• Similarity: 348/845 - (41%)
• Gaps: 263/845 - (31%)

  Fly     6 IKVAVRVRPFNRRE----------------------------------IELDT------------ 24
            |.||:|||||...|                                  |::|.
Yeast    11 IVVAIRVRPFTSMEKTRLVNEASGAEANFPGLGDSSLILPMSNNSDSDIDIDAEEGSTRSKRNSL 75

  Fly    25 -----------KCIVEMEKQQTILQNPP---PLEKIE---------RKQPKT------------- 53
                       :.||:....:.::.:|.   ||.|:.         |....|
Yeast    76 LRRKVIRPEGIRKIVDCVDDRMLIFDPADRNPLNKVSDQVLNSMRARATKATASSINNSNATNKF 140

  Fly    54 ------------FAFDHCFYSLNPEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGK 106
                        |.||..|      ||. :||..|:......:||:...|:|:.:||||.||.||
Yeast   141 SSQRRRHGGEIKFVFDKLF------DET-SSQARVYKETTSPLLDSVLDGFNSTVFAYGATGCGK 198

  Fly   107 SYTMMGTQESKGIIPRLCDQLFSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVR 171
            :||:.||....|||....::||:.|.:.. .|..:::.:||:|||||::.|||.|:...:.|.:|
Yeast   199 TYTVSGTPSQPGIIFLAMEELFNKITDLK-DEKDFEISLSYLEIYNERIRDLLKPETPSKRLVIR 262

  Fly   172 EHNVMGPYVDGLSQLAVTSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQI-----L 231
            |.......|..||.....:.:|:.:|:.:||.:||.:.|..|..|||||||..:.:.|.     |
Yeast   263 EDTQNHIKVANLSYHHPNTVEDVMDLVVQGNINRTTSPTEANEVSSRSHAVLQIHIMQTNKLVDL 327

  Fly   232 TDQATGVSGEKVSRMSLVDLAGSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKS 296
            |.|.|      .:.:|::||||||||..|...|.||.||:|||:||..||..|:.|. .::|.:|
Yeast   328 TSQHT------FATLSIIDLAGSERAAATRNRGIRLHEGANINRSLLALGNCINALC-LNDGSRS 385

  Fly   297 GNDKFVPYRDSVLTWLLKDNLGGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNED 361
            .:   :|||||.||.|||.:||||.:|||:..||||:.:|:|||:||:||:|||.|....:.|:.
Yeast   386 CH---IPYRDSKLTRLLKFSLGGNCKTVMIVCISPSSSHYDETLNTLKYANRAKEIKTKIIRNQQ 447

  Fly   362 PNAR-------IIRELRHEVETLRSMLKHATGSPVGDVQDKLAESENLMKQISQTWEEKLVKTER 419
            ..:|       :|.|.:.::|.||                   |.|..|..:..| :.||.| |:
Yeast   448 SLSRHVGSYLKMITEQKRQIEELR-------------------EREEKMISLKLT-KYKLNK-EK 491

  Fly   420 IQ-------NERQQ---ALEKMGISVQASGIKVEKNKY-YLVNLNADPSLNELLVYYLKDRT--- 470
            ||       |..||   .:|...::.....:.:.|.:: .:|.|..|   |.:|::..::.|
Yeast   492 IQLAINECVNRVQQTYAGVETYQVAKTLKSLILCKRRFLQMVKLEVD---NLILLFEREESTAAE 553

  Fly   471 ----LIGGRTISGQ-------------QPDIQLSGLGIQPEHCVITIEDSGL------------- 505
                :...|.||||             :.|...|.:     |.|.:|:.:.|
Yeast   554 MQPVISNCRMISGQLYNKIHELEMKFDETDTLSSVI-----HQVHSIDLNKLREMEDWDETYDLV 613

  Fly   506 YME-------PVQGARCFVNGSAAVEK---------------------TPLQNGDRILWGNHH-- 540
            |:|       .:|.....||.|...||                     ||  |.:.|:....|
Yeast   614 YLESCLNQISELQRNEILVNSSIMTEKLMSDPGLNSRFKFLSKWLMNRTP--NIESIIQDLVHID 676

  Fly   541 -----FFR--VNSPKSN--NTSM-----CASEPQTPAQLID-YNFARDEI--MQNELSNDPIQTA 588
                 |.|  :.:|.||  ||::     .|::...||:.:. .||::.::  ...:||..|:...
Yeast   677 EEFESFARTFIANPDSNFTNTNINIINTTAADLAVPAETLQRQNFSQKKVKWTSPDLSPSPMIEP 741

  Fly   589 IARLERQ-HEEDKQVALEKQRQEYERQFQQLRNILSPSTPYAPYAPYDPLRMGKITPNTPTSQMR 652
            ...||.: |::...:|.|......:..|    |...||||.||            |...|..:||
Yeast   742 QPELEPELHQDQDAIASEVDVSMQDTTF----NEQGPSTPSAP------------TTAVPRRKMR 790

  Fly   653  652
            Yeast   791  790

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	147/451 (33%)
		Kinesin_assoc	356..468	CDD:465047	27/129 (21%)
		FHA_KIF13	446..547	CDD:438758	32/171 (19%)
		KIF1B	741..786	CDD:463574
		DUF3694	989..1243	CDD:463599
		CAP_GLY	1785..1850	CDD:460154
KIP3	NP_011299.1	KISc_KIP3_like	82..438	CDD:276821	135/373 (36%)