DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Khc-73 and KIF2B

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	NP_115948.4	Gene:	KIF2B / 84643	HGNCID:	29443	Length:	673	Species:	Homo sapiens

Alignment Length:	440	Identity:	153/440 - (34%)
Similarity:	220/440 - (50%)	Gaps:	67/440 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KIKVAVRVRPFNRREIELDTKCIVEMEKQQTIL--QNPPPLEKIERKQPKTFAFDHCFYSLNPED 67
            :|.|.||.||.|:||..|....|:.:.....::  ::...::.....|.:||.|||.|
Human   213 RICVCVRKRPLNQRETTLKDLDIITVPSDNVVMVHESKQKVDLTRYLQNQTFCFDHAF------- 270

  Fly    68 ENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTM----MGTQE--SKGIIPRLCDQ 126
            ::.||.|.|:....:.::::.|:...|..||||||||||:|||    .||.:  ||||...:...
Human   271 DDKASNELVYQFTAQPLVESIFRKGMATCFAYGQTGSGKTYTMGGDFSGTAQDCSKGIYALVAQD 335

  Fly   127 LFSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSY 191
            :|..:.|.:..:|..||..::.|||..||:|||:   .|:.|:|.|.......|.||.:..|...
Human   336 VFLLLRNSTYEKLDLKVYGTFFEIYGGKVYDLLN---WKKKLQVLEDGNQQIQVVGLQEKEVCCV 397

  Fly   192 QDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKV-SRMSLVDLAGSE 255
            :::.||:..||..||...|.:||.||||||||.::|.          ||..: .:.|||||||:|
Human   398 EEVLNLVEIGNSCRTSRQTPVNAHSSRSHAVFQIILK----------SGRIMHGKFSLVDLAGNE 452

  Fly   256 R-AVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDN-LG 318
            | |..|.|...|..||:.|||||..|...|..|..        |....|:|.|.||.:|:|: :|
Human   453 RGADTTKASRKRQLEGAEINKSLLALKECILALGQ--------NKPHTPFRASKLTLVLRDSFIG 509

  Fly   319 GNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNED--PNARIIRELRHEVETLRSML 381
            .||.|.|:|||||...:.|.||:|||||:|.|::      |.|  |..|....:.||..   .||
Human   510 QNSSTCMIATISPGMTSCENTLNTLRYANRVKKL------NVDVRPYHRGHYPIGHEAP---RML 565

  Fly   382 KHATGSPVGDVQDKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKM 431
            |    |.:|:.:..|...|             .:|...:|:|.|:.:|::
Human   566 K----SHIGNSEMSLQRDE-------------FIKIPYVQSEEQKEIEEV 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	135/364 (37%)
		KISc	6..359	CDD:214526	135/363 (37%)
		Kinesin_assoc	356..468	CDD:292801	18/78 (23%)
		FHA	446..546	CDD:238017
		KIF1B	741..786	CDD:289208
		DUF3694	<1196..1252	CDD:289256
		CAP_GLY	1786..1850	CDD:279625
KIF2B	NP_115948.4	KISc_KIF2_like	213..541	CDD:276818	134/355 (38%)
KIF2B	NP_115948.4	Kinesin	219..541	CDD:278646	131/349 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910