DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc-73 and AT1G72250

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	NP_001320541.1	Gene:	AT1G72250 / 843557	AraportID:	AT1G72250	Length:	1216	Species:	Arabidopsis thaliana

Alignment Length:	896	Identity:	231/896 - (25%)
Similarity:	359/896 - (40%)	Gaps:	269/896 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IKVAVRVRPFNRREIELDTKCIVEMEKQQT----ILQNPPPLEKIERKQPKTFAFDHCFYSLNPE 66
            |:|..|.||.|..|.|......:::|..:.    ::.|..|        .|:|.||..|   .|.
plant   513 IRVFCRCRPLNFEETEAGVSMGIDVESTKNGEVIVMSNGFP--------KKSFKFDSVF---GPN 566

  Fly    67 DENFASQETVFDCVGRGILDNA------FQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCD 125
                |||..||:       |.|      ..|||.|||||||||:||::||.|||..:|:..|..:
plant   567 ----ASQADVFE-------DTAPFATSVIDGYNVCIFAYGQTGTGKTFTMEGTQHDRGVNYRTLE 620

  Fly   126 QLFSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQS----LKVREHNVMGPYVDGLSQL 186
            .||..|..:. ....|::.||.:|:|||::.|||.|.....|    .::|:.:....:|.||.:.
plant   621 NLFRIIKARE-HRYNYEISVSVLEVYNEQIRDLLVPASQSASAPKRFEIRQLSEGNHHVPGLVEA 684

  Fly   187 AVTSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKV-------S 244
            .|.|.:::.:::..|:.:|.|..|..|..|||||.:..|:           |.||.:       |
plant   685 PVKSIEEVWDVLKTGSNARAVGKTTANEHSSRSHCIHCVM-----------VKGENLLNGECTKS 738

  Fly   245 RMSLVDLAGSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVL 309
            ::.|||||||||..||...|:||||..||||||:.||.||..||::|:        .:|:|:|.|
plant   739 KLWLVDLAGSERVAKTEVQGERLKETQNINKSLSALGDVIFALANKSS--------HIPFRNSKL 795

  Fly   310 TWLLKDNLGGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEV 374
            |.||:|:|||:|:|:|...|||:.::..|||.:|.:|.|.:
plant   796 THLLQDSLGGDSKTLMFVQISPNENDQSETLCSLNFASRVR------------------------ 836

  Fly   375 ETLRSMLKHATGSPVGDVQDKLAESENL-MKQISQTWEEKLVKTERIQNERQQALEKMGISVQAS 438
                       |..:|..:.:|..:|.| .||:.:.|::.:    :.::|:.:.:|:....::|.
plant   837 -----------GIELGPAKKQLDNTELLKYKQMVEKWKQDM----KGKDEQIRKMEETMYGLEAK 886

  Fly   439 GIKVEKNKYYLVNLNADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVITIEDS 503
             ||....|    |......:.||....|.:|.|
plant   887 -IKERDTK----NKTLQDKVKELESQLLVERKL-------------------------------- 914

  Fly   504 GLYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNTSMCASEPQTPAQLID- 567
                     ||..|:...|.::|..|..|                .||||   ..|.....|:.
plant   915 ---------ARQHVDTKIAEQQTKQQTED----------------ENNTS---KRPPLTNILLGS 951

  Fly   568 -----YNFARDEIMQNELSND--PIQTAIARL------ERQHEEDKQVALEKQRQEYERQFQQLR 619
                 .|..|..::::..|.|  |:.:.:.:.      |...|...||.|..:...:
plant   952 ASKEMVNLTRPSLLESTTSYDLAPLPSGVPKYNDLSEKENNPEMADQVHLPNKTGRF-------- 1008

  Fly   620 NILSPSTPYAPYAPYDPLRMGKITPNTPTSQMRVEKWAQERDEMFRRSLGQLKTDI--------- 675
            :|.:...|.|| ||    |...:.|.|.||        :|...:.|..|.:..|..
plant  1009 SICAKRIPSAP-AP----RRSSLAPTTSTS--------REMVYLTRPPLSESTTSYDLPPLPNGG 1060

  Fly   676 MRANSLVQEAN--FLAEEMEKKTKFSV------TLQIPPANLSPNRRRGAFVSEPAILVKRT--- 729
            ::.:.|:::.|  .:||:::...:...      ..:||||     .||.:|...|.|.:..|
plant  1061 LKYSDLIEKVNNQEMAEQVQIPKRIGAGRSSICAKRIPPA-----PRRKSFAPMPFIPITSTLTS 1120

  Fly   730 ---NSGSQ--IWTMEKL---ENKLID--MREMYQEHKERVLNGLDEDNAKP---QDPFYESQENH 781
               .||:.  :.|..||   ..|.:.  :|...|:..:          .||   |.|....
plant  1121 PDEKSGANQVLCTSPKLHRSNGKTLTSILRRSIQKRMQ----------MKPSPRQQPMRRG---- 1171

  Fly   782 NLIGVANIFLEVLFHDVKLDYHTPIISQQGEVAGRLQVEIERIAG--QMPQ 830
               |..|:.:|    .|:|.     |..:|.:|.|:.:...|.||  :.||
plant  1172 ---GGINVGME----RVRLS-----IGNRGRLAHRVLLTNARKAGLKETPQ 1210

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	133/373 (36%)
		KISc	6..359	CDD:214526	133/373 (36%)
		Kinesin_assoc	356..468	CDD:292801	18/112 (16%)
		FHA	446..546	CDD:238017	14/99 (14%)
		KIF1B	741..786	CDD:289208	8/52 (15%)
		DUF3694	<1196..1252	CDD:289256
		CAP_GLY	1786..1850	CDD:279625
AT1G72250	NP_001320541.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910