DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Khc-73 and AT1G55550

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	NP_564696.2	Gene:	AT1G55550 / 842004	AraportID:	AT1G55550	Length:	859	Species:	Arabidopsis thaliana

Alignment Length:	743	Identity:	198/743 - (26%)
Similarity:	320/743 - (43%)	Gaps:	170/743 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IKVAVRVRPFNRRE-----IELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYSLNP 65
            |:|..||:|....|     :..||:.::               .|:...:.||:.||..|...:.
plant    92 IRVFCRVKPLGATEKLRPPVASDTRNVI---------------IKLSETKRKTYNFDRVFQPDSS 141

  Fly    66 EDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCDQLFSA 130
            :|:.|...|.|.    :.::|    |||||||||||||:||:|||.|...|.||:||....||..
plant   142 QDDVFLEIEPVI----KSVID----GYNACIFAYGQTGTGKTYTMEGLPNSPGIVPRAIKGLFKQ 198

  Fly   131 IANKSTPELMYKVEVSYMEIYNEKVHDLL--------DPKPNKQSLKVREHNVMGPYVDGLSQLA 187
            :...:.   |:.:..|.:|||...:.|||        .|.|...|:....:..:.  ::.|.:|.
plant   199 VEESNH---MFTIHFSMLEIYMGNLKDLLLSEATKPISPIPPSLSIHTDPNGEID--IENLVKLK 258

  Fly   188 VTSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLA 252
            |..:.:|..|...|.:||..|:||.|:.|||||.:..|.:|.:...:..    .:.:::.||||.
plant   259 VDDFNEILRLYKVGCRSRATASTNSNSVSSRSHCMIRVSVTSLGAPERR----RETNKIWLVDLG 319

  Fly   253 GSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNL 317
            ||||.:||.|.|.|..||..||.||:.||.||:.|..:::        .:|||:|.||.:|||:|
plant   320 GSERVLKTRATGRRFDEGKAINLSLSALGDVINSLQRKNS--------HIPYRNSKLTQVLKDSL 376

  Fly   318 GGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARI--------IRELRHEV 374
            |.:|:|:|:..|||..|:..||:.:|.:|.|||.|  |...:|....:.        ::::..::
plant   377 GQDSKTLMLVHISPKEDDLCETICSLNFATRAKNI--HLGQDESTEEQAKKEAVMMNLQKMMEKI 439

  Fly   375 ETLRSM-----------LKHATGSPVGDVQDKLAESENLMKQISQTWEEK--------------L 414
            |..|.|           |:..||.|  .|.::  |.:::::::.....:|              .
plant   440 EQEREMSLRKMRNLNETLEKLTGKP--HVIEE--EEKDVVREVIHVTPKKPRNKSRRASDVFPSF 500

  Fly   415 VKTERIQNERQQALE--------------KMGISVQASG----IKVEKNKYYLVNLNADPSLNE- 460
            ::.....|.|....:              ...|||:|..    :|.:||::.....::|.|:::
plant   501 MRPTASSNRRLSGADFSVTPNSSSFKSRRNSMISVRAESACLPVKKKKNRFDSACDSSDRSVSKS 565

  Fly   461 --LLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVITIEDSGLYMEPVQGARCFVNGSAAV 523
              ::.....|...:..:.||  :.||:|    :..||     :...|.|.|         |||..
plant   566 TSIMRQNTADDATVYSQDIS--ECDIKL----VVSEH-----KPKPLQMGP---------GSATK 610

  Fly   524 EKTPLQNGDRILW---GNHHFFRVNS---PKSNNTSMCASEPQTPAQ--LIDYN----------F 570
            .::.:.|.::.:.   |...|.|:||   .:|.|.|....:.|.||.  |.:.|          |
plant   611 SRSNISNFEKDVMQKIGGTEFSRINSWLRSQSENRSYVLDKTQLPATHFLENLNRSLEKSPTQSF 675

  Fly   571 ARDEIMQNEL-------SNDPIQTAIARLERQHEEDKQVALEKQRQEYERQFQQLRNILSPSTPY 628
            ..::|..|||       :|:.:......|::..|.....:.|::.|           ||| ..|.
plant   676 TTEKITGNELEGIEETKTNETVVNPTLMLKKLFELQCLCSAEEEDQ-----------ILS-RFPI 728

  Fly   629 APYAPYDPLRMGKITPNTPTSQMRVEKW 656
            ..|...|..|...|..|...||....:|
plant   729 PGYEDDDESRYPPILENDGFSQHIDNEW 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	126/365 (35%)
		KISc	6..359	CDD:214526	126/365 (35%)
		Kinesin_assoc	356..468	CDD:292801	22/165 (13%)
		FHA	446..546	CDD:238017	20/105 (19%)
		KIF1B	741..786	CDD:289208
		DUF3694	<1196..1252	CDD:289256
		CAP_GLY	1786..1850	CDD:279625
AT1G55550	NP_564696.2	Motor_domain	89..411	CDD:277568	124/358 (35%)
AT1G55550	NP_564696.2	Kinesin	97..411	CDD:278646	122/353 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910