DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Khc-73 and AT1G18550

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	NP_173290.4	Gene:	AT1G18550 / 838436	AraportID:	AT1G18550	Length:	725	Species:	Arabidopsis thaliana

Alignment Length:	723	Identity:	194/723 - (26%)
Similarity:	328/723 - (45%)	Gaps:	187/723 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KIKVAVRVRPFNRREIELDTKCIVEMEKQQ----TILQNPPPLEKIERKQPKTFAFDHCFYSLNP 65
            :|.|.||:||..::|.|..::|.|::..::    |...|.....:::|.:.:.|.||..|    |
plant   151 RILVFVRLRPMGKKERENGSRCCVKVLNKRDVYLTEFTNENDYLRLKRLRVRHFTFDSSF----P 211

  Fly    66 EDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCDQLFSA 130
            |.   .:|:.|:......:::...:|.|..:|.||.||:||:|||:||.|:.|::......||:.
plant   212 ET---TTQQEVYSTTTGDLVEAVLEGRNGSVFCYGATGAGKTYTMLGTMENPGVMVLAIKDLFAK 273

  Fly   131 IANKSTPELMYKVEVSYMEIYNEKVHDLLDP-KPNKQSLKVREHNVMGPYVDGLSQLAVTSYQDI 194
            :..:|. :..:.|.:||:|:|||.|.|||.| :|    |.:|| :..|....||:|....|..::
plant   274 VRQRSL-DGNHVVHLSYLEVYNETVRDLLSPGRP----LILRE-DKQGIVAAGLTQYRAYSTDEV 332

  Fly   195 DNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSERAVK 259
            ..|:..||::||...|..|..||||||:..|::.....|.:..:. .:|.::||:||||||||:.
plant   333 MALLQRGNQNRTTEPTRCNETSSRSHAILQVIVEYKTRDASMNII-SRVGKLSLIDLAGSERALA 396

  Fly   260 TGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLGGNSRTV 324
            |.....|..||:|||:||..|...|:.|.:   ||     |.:|||:|.||.||||:|||:..||
plant   397 TDQRTLRSLEGANINRSLLALSSCINALVE---GK-----KHIPYRNSKLTQLLKDSLGGSCNTV 453

  Fly   325 MVATISPSADNYEETLSTLRYADRAKRI-VNHAVVNEDPNARIIRELRHEVETLRSMLKHATGSP 388
            |:|.||||:.::.||.:||.:|||||.| |....|||:    :::                .|..
plant   454 MIANISPSSQSFGETQNTLHWADRAKEIRVKECEVNEE----VVQ----------------VGEE 498

  Fly   389 VGDVQDKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQASGIKVEKNKYYLVNLN 453
            .|..|.||.  ..|.|:.|:.         |:|..:||  :|: :::||..|....|..   |::
plant   499 EGADQAKLL--LELQKENSEL---------RVQLAKQQ--QKL-LTLQAENIAAANNNN---NIS 546

  Fly   454 -ADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVITIEDSGLYMEPVQGARCFV 517
             ..||::.|:.         ....::.||..        :|.|.:::             ..||
plant   547 LTPPSISSLMT---------PPSALTAQQKK--------KPRHSLLS-------------GTCF- 580

  Fly   518 NGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNTSMCASEPQTPAQLIDYNFARDEIMQNELSN 582
                                        :|:|                :....|.:.:.:.:|:.
plant   581 ----------------------------TPES----------------LKRTKAEEAVKELQLTV 601

  Fly   583 DPIQTAIARLERQHEEDKQVALEKQRQEYERQFQQLRNILSPSTPYAPYAPYDPLRM---GKITP 644
            ..::..:.|::|:|    .:.::||:.|.      ::::.|..:...|....:..|:   |.:.|
plant   602 KALKMEMERMKREH----GLQMKKQKDEL------MKDLCSRKSEKTPERCKETRRIVTRGSLRP 656

  Fly   645 NTPTSQMRVEKWAQERDEMFRRSLGQLKTDIMRANSLVQEANFLAEEMEKKTKFSVTLQIPPANL 709
                         :|:::       :||:...|..|.|..|       :|::.:.:|:    ||.
plant   657 -------------KEKEK-------ELKSPSHRFASPVAAA-------KKRSFWDITV----ANT 690

  Fly   710 SP--NRRR 715
            ||  :||:
plant   691 SPALDRRK 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	134/359 (37%)
		KISc	6..359	CDD:214526	134/358 (37%)
		Kinesin_assoc	356..468	CDD:292801	24/112 (21%)
		FHA	446..546	CDD:238017	10/100 (10%)
		KIF1B	741..786	CDD:289208
		DUF3694	<1196..1252	CDD:289256
		CAP_GLY	1786..1850	CDD:279625
AT1G18550	NP_173290.4	Kinesin	157..481	CDD:395169	129/345 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910