DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Khc-73 and AT5G27550

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	NP_001318663.1	Gene:	AT5G27550 / 832815	AraportID:	AT5G27550	Length:	765	Species:	Arabidopsis thaliana

Alignment Length:	728	Identity:	205/728 - (28%)
Similarity:	325/728 - (44%)	Gaps:	154/728 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IKVAVRVRPFNRREI--------ELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYS 62
            |:|..|.||.|:.||        |.||    ..|.:..||.:.        ...|.|.|||.|
plant   133 IRVFCRCRPLNQAEIANGCASVAEFDT----TQENELQILSSD--------SSKKHFKFDHVF-- 183

  Fly    63 LNPEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCDQL 127
             .|:|    .||||| ...:.|:.:...|||.|||||||||:||::||.||.|::|:..|..::|
plant   184 -KPDD----GQETVF-AQTKPIVTSVLDGYNVCIFAYGQTGTGKTFTMEGTPENRGVNYRTLEEL 242

  Fly   128 FSAIANKSTPELM-YKVEVSYMEIYNEKVHDLLDPKPNK--QSLKVREHNVMGPYVDGLSQLAVT 189
            |....:||  .|| :::.||.:|:||||:.|||....|:  :.|:|::.......|.||.:..|.
plant   243 FRCSESKS--HLMKFELSVSMLEVYNEKIRDLLVDNSNQPPKKLEVKQSAEGTQEVPGLVEAQVY 305

  Fly   190 SYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKV-------SRMS 247
            :...:.:|:.:|...|:|.:|..|.:|||||.:..|.           |.||.:       |.:.
plant   306 NTDGVWDLLKKGYAVRSVGSTAANEQSSRSHCLLRVT-----------VKGENLINGQRTRSHLW 359

  Fly   248 LVDLAGSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWL 312
            |||||||||..|....|:||||...|||||:.||.|||.||.:::        .:|||:|.||.:
plant   360 LVDLAGSERVGKVEVEGERLKESQFINKSLSALGDVISALASKTS--------HIPYRNSKLTHM 416

  Fly   313 LKDNLGGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVN-----HAVVNEDPNARIIRE-LR 371
            |:::|||:.:|:|...||||:.:..|||.:|.:|.|.:.|.:     .|.|:|...::.:.| |:
plant   417 LQNSLGGDCKTLMFVQISPSSADLGETLCSLNFASRVRGIESGPARKQADVSELLKSKQMAEKLK 481

  Fly   372 HEVETLRSMLKHATGSPVGDVQDKLAESENLMKQIS--------QTWEEKLVKTERIQNERQQAL 428
            ||.:..:.:..:     |..:|.:|...|::.:.:.        |..||:  || ||:.| .:||
plant   482 HEEKETKKLQDN-----VQSLQLRLTAREHICRGLQDKVRDLEFQLAEER--KT-RIKQE-SRAL 537

  Fly   429 EKMGISVQASGIKVEKNKYYLVNLNADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQP 493
                  ..||......:::....|   |::.|........|..:..|.|:...|.
plant   538 ------ATASSTTTTTSRHLRETL---PTIIEKKPPLAPTRMRMPLRRITNFMPQ---------- 583

  Fly   494 EHCVITIEDSGLYMEPVQG-ARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNT----- 552
                         .:|.|| ::.|              .|.....|::..|.:|....||
plant   584 -------------QQPSQGHSKRF--------------SDTTFKENNNSNRRSSSMDVNTLMKPR 621

  Fly   553 -SMCASEP-QTPAQLIDYN---FARDEIMQNELSNDPIQTAIARLERQHEEDKQVALEKQRQEYE 612
             |..|..| ..|:.:...|   ..|..:....|..:|  ::::.:|...........:.::..|.
plant   622 RSSIAFRPAPAPSAIASSNKTIMPRRRVSIATLRPEP--SSLSSMETPSRPPPSFRGDPRKARYS 684

  Fly   613 RQFQQLRNILSPSTPYAPYAPYDPLRMGKIT--PNTPT---SQMRVEKWAQERDEMFRRSLGQLK 672
            :.|...||:::|:...:......||..|..:  |:.||   .|.:...|:..:.:..|.||..::
plant   685 KLFSPDRNLVTPNAMKSSRFMKSPLGGGGSSWKPSHPTVIALQKKAVVWSPLKFKNRRPSLVAIR 749

  Fly   673 --------TDIMR 677
                    :|::|
plant   750 SSASSSSASDLLR 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	139/375 (37%)
		KISc	6..359	CDD:214526	139/375 (37%)
		Kinesin_assoc	356..468	CDD:292801	26/120 (22%)
		FHA	446..546	CDD:238017	14/100 (14%)
		KIF1B	741..786	CDD:289208
		DUF3694	<1196..1252	CDD:289256
		CAP_GLY	1786..1850	CDD:279625
AT5G27550	NP_001318663.1	KISc_C_terminal	130..457	CDD:276817	137/364 (38%)
AT5G27550	NP_001318663.1	ATG16	<464..537	CDD:400781	19/81 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910