DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Khc-73 and AT5G06670

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	NP_001318493.1	Gene:	AT5G06670 / 830555	AraportID:	AT5G06670	Length:	986	Species:	Arabidopsis thaliana

Alignment Length:	1109	Identity:	284/1109 - (25%)
Similarity:	448/1109 - (40%)	Gaps:	327/1109 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ASDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYSLNPE 66
            :.:.:.|.||.||.:.|||....: |......:||::|       |..|...:|:|..|   .|.
plant    63 SKENVTVTVRFRPLSPREIRKGEE-IAWYADGETIVRN-------ENNQSIAYAYDRVF---GPT 116

  Fly    67 DENFASQETVFDCVGRGILDNAFQGYN---------ACIFAYGQTGSGKSYTMMGTQESKGIIPR 122
                .:...|:|...:.:::.|..|.|         ..|||||.|.|||::||.|.|.|.||||.
plant   117 ----TTTRNVYDVAAQHVVNGAMAGVNVTLSVNSTTGTIFAYGVTSSGKTHTMHGNQRSPGIIPL 177

  Fly   123 LCDQLFSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLA 187
            .....||.|  :.||...:.:.|||.|||||.|:|||:|.  .|:|::|| :..|.|::|:.:..
plant   178 AVKDAFSII--QETPRREFLLRVSYFEIYNEVVNDLLNPA--GQNLRIRE-DEQGTYIEGIKEEV 237

  Fly   188 VTSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVL-TQILTDQATGVSGEKVSRMSLVDL 251
            |.|...:.:|:..|.:.|.:.:|:.|..|||||.:|::.: :..|.|...| ....:|:::|:||
plant   238 VLSPAHVLSLIAAGEEHRHIGSTSFNLLSSRSHTMFTLTIESSPLGDNNEG-GAVHLSQLNLIDL 301

  Fly   252 AGSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDN 316
            ||||.: |....|.|.||||.|||||.|||.|||||.|:       ....||||||.||.||:.:
plant   302 AGSESS-KAETSGLRRKEGSYINKSLLTLGTVISKLTDR-------RASHVPYRDSKLTRLLESS 358

  Fly   317 LGGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNE--DPNARI------IRELRHE 373
            |.|:.|..::.|::|::.|.|||.:||::|.|||.|...|..|:  |..:.|      ||:|:.|
plant   359 LSGHGRVSLICTVTPASSNSEETHNTLKFAHRAKHIEIQAAQNKIIDEKSLIKKYQYEIRQLKEE 423

  Fly   374 VETLR------SMLKHATGSPVGDV--QDKLAESEN----LMKQISQTWEEKLVKTERIQNERQQ 426
            :|.|:      |.||..:|..:..|  :.||.|.|:    |:.:|     ::|.|...:.|:..|
plant   424 LEQLKQGIKPVSQLKDISGDDIDIVLLKQKLEEEEDAKAALLSRI-----QRLTKLILVSNKTPQ 483

  Fly   427 ALEKMGISVQASGIKVEKNKYYLVNLNADP----SLNELLVYYL--KDRTLIGGRTISGQQPDIQ 485
            ...                    .:..|||    |..|..:.||  |.|.|.....:     ::.
plant   484 TSR--------------------FSYRADPRRRHSFGEEELAYLPHKRRDLTDDENL-----ELY 523

  Fly   486 LSGLGIQPEHCVITIEDSGLYMEPVQGARCFVNGSAAVEKTPLQNG----------DRILWGNHH 540
            :|..| .||    .|:|:            |:.     ||...::|          |..|.|:..
plant   524 VSREG-TPE----IIDDA------------FIE-----EKKTRKHGLLNWLKIKKKDSSLGGSSL 566

  Fly   541 FFRVNSPKSNNTSMCASEPQ-------TPAQLIDYNFARDEIMQ-------NELSNDPIQTAIAR 591
            ..:.::.|||:|   .|.||       |.::|.:.:...|:|::       :|.|...|:|...|
plant   567 SDKSSAVKSNST---PSTPQGEGSDFHTESRLSEGSALADQIIETMENREAHEDSFHEIETPETR 628

  Fly   592 LERQHEEDKQVALEKQRQEYERQFQQLRN--ILSPSTPYAP------------------------ 630
            ::.  .:..::..|:|:...|...||.|:  :||.....||
plant   629 IKM--IDQMEILREQQKTLSEEMAQQSRSFKLLSEEAAKAPQNEEIKAEIINLNGDIKAKNDQIA 691

  Fly   631 ----------YAPYDPLRMGKITPNTPTSQMRVEKWAQERDEMFRRSLGQLKTDIMRA-NSLVQE 684
                      .|.:|.|....|.  ...|:||    ||..::.|       :.::..| |.::|
plant   692 TLGKQILDFVIASHDELDKSDIV--QAVSEMR----AQLNEKCF-------ELEVKAADNRIIQ- 742

  Fly   685 ANFLAEEMEKKTKFSVTLQIPPANL-------------------------SPNRRRGAFVSEPAI 724
                 |::.:||.|...||...|||                         |||:.....:.
plant   743 -----EQLTEKTSFCEDLQEEVANLKQQLSDALELGDINSVTCHMQQSSQSPNKNEEKVIE---- 798

  Fly   725 LVKRTNSGSQIWTMEKLENKLIDMREMYQEHKERVLNGLDEDNAKPQDPFYESQENHNLIGVANI 789
                    :|.:.:|:|:.|..::.|:.::        |:..|.|..:   ||.....|...|.|
plant   799 --------AQAFEIEELKLKAAELSELNEQ--------LEIRNKKLAE---ESSYAKELASAAAI 844

  Fly   790 FLEVLFHDVKLDYHTPIISQQGEVAGRLQVEIERIAGQMPQDRMCESVSESSGDSRDEYDDPVDP 854
            .|:.|..::                .||....||:|..:      .:|.:||      ...|...
plant   845 ELKALSEEI----------------ARLMNHNERLAADL------AAVQKSS------VTTPQGK 881

  Fly   855 TSNQITCRVTIKCASGLPLSLSNFVFCQYTFWGHQEMVVPVINAESTAHDQNMVFKFEHTQDFTV 919
            |.|                 |.|         |.:|.|      ......:|.:.:.:.    .:
plant   882 TGN-----------------LRN---------GRRESV------SKRKEQENSLMELKR----EL 910

  Fly   920 TINEEFLEHCIEGALSIEVWGHRSAGFSKTKGWEVEQQQAKARSLVDRWAELSRKIELWVEIHEL 984
            |:::| .|...|.||..::  .|.|...:|    ||:.:.:...|.:..|      .:|..:.:|
plant   911 TVSKE-REVSFEAALIEKI--QREAELQRT----VEESKQREAYLENELA------NMWGLVAKL 962

  Fly   985 NDNG 988
            ...|
plant   963 RSQG 966

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	138/364 (38%)
		KISc	6..359	CDD:214526	138/362 (38%)
		Kinesin_assoc	356..468	CDD:292801	32/137 (23%)
		FHA	446..546	CDD:238017	23/115 (20%)
		KIF1B	741..786	CDD:289208	9/44 (20%)
		DUF3694	<1196..1252	CDD:289256
		CAP_GLY	1786..1850	CDD:279625
AT5G06670	NP_001318493.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910