DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc-73 and AT4G39050

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	NP_195616.2	Gene:	AT4G39050 / 830060	AraportID:	AT4G39050	Length:	1055	Species:	Arabidopsis thaliana

Alignment Length:	949	Identity:	251/949 - (26%)
Similarity:	387/949 - (40%)	Gaps:	279/949 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYSLNPEDE 68
            |.|.|.||.||.:.||.:...:.....:....:.....||        ..:|||..|   .|:
plant    97 DSISVTVRFRPLSDREYQRGDEVAWYPDGDTLVRHEYNPL--------TAYAFDKVF---GPQ-- 148

  Fly    69 NFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCDQLFSAIAN 133
              |:...|:|...|.::..|.:|.|..:||||.|.|||::||.|.|||.||||.....:||.|
plant   149 --ATTIDVYDVAARPVVKAAMEGVNGTVFAYGVTSSGKTHTMHGDQESPGIIPLAIKDVFSII-- 209

  Fly   134 KSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQDIDNLM 198
            :.||...:.:.|||:|||||.::||||  |..|:|:|||.: .|.||:|:.:..|.|.....:.:
plant   210 QDTPGREFLLRVSYLEIYNEVINDLLD--PTGQNLRVREDS-QGTYVEGIKEEVVLSPGHALSFI 271

  Fly   199 TEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATG--VSGEKVSRMSLVDLAGSERAVKTG 261
            ..|.:.|.|.:.|.|..|||||.:|    |.::...|||  ..|...|:::|:||||||.: ||.
plant   272 AAGEEHRHVGSNNFNLLSSRSHTIF----TLMVESSATGDEYDGVIFSQLNLIDLAGSESS-KTE 331

  Fly   262 AVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLGGNSRTVMV 326
            ..|.|.||||.|||||.|||.||.||::       |....:|||||.||.||:.:|.|:....::
plant   332 TTGLRRKEGSYINKSLLTLGTVIGKLSE-------GKATHIPYRDSKLTRLLQSSLSGHGHVSLI 389

  Fly   327 ATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNAR-IIRELRHEVETLRSMLKH-ATGSPV 389
            .||:|::.:.|||.:||::|.|||.|..:|..|:..:.: :|::.:.|:.||:..|.. ..|..|
plant   390 CTITPASSSSEETHNTLKFASRAKSIEIYASRNQIIDEKSLIKKYQREISTLKLELDQLRRGMLV 454

  Fly   390 GDVQDKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQASGIKVEKNKYYLVNLNA 454
            |      ...|.|| .:.|..||..||.:....|.::|...:...:|
plant   455 G------VSHEELM-SLKQQLEEGQVKMQSRLEEEEEAKAALMSRIQ------------------ 494

  Fly   455 DPSLNELLVYYLKDRTLIGGRTISGQQPDIQLS-GLGIQPEHCVITIEDSGLYMEPVQGARCFVN 518
              .|.:|::...|:.  |.|  .||..|..|.| ..|...:...:.:|...|
plant   495 --KLTKLILVSTKNS--IPG--YSGDIPTHQRSLSAGKDDKFDSLLLESDNL------------- 540

  Fly   519 GSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNTSMCASE----PQTPAQLIDYNFARDEIMQNE 579
            ||.:.....|..|.  |..||   |.:|.|.|:.:...:|    ..||.: ||....:.:::..|
plant   541 GSPSSTLALLSEGS--LGFNH---RRSSSKLNDENSPGAEFTQGVMTPDE-IDLLVEQVKMLAGE 599

  Fly   580 LS--------------NDP--IQTAIARLERQ-HEEDKQVALEKQRQEYERQFQQLRNILSPSTP 627
            ::              |||  .||.|..|||: ||:.:|:          |..:||
plant   600 IAFSTSTLKRLVDQSVNDPENSQTQIQNLEREIHEKQRQM----------RGLEQL--------- 645

  Fly   628 YAPYAPYDPLRMGKITPNTPTSQMRVEKWAQERDEMFRRSLGQLKTDIMRANSLVQEANFLAEEM 692
                    .:..|:.:                   :...||.:::..:|   ||:.:.|..:.|:
plant   646 --------IIESGEAS-------------------IANASLVEMQQKVM---SLMTQCNEKSFEL 680

  Fly   693 EKKTKFSVTLQIPPANLSPNRRRGAFVSEPAILVKRTNSGSQIWTMEKLENKLIDMREMYQEHK- 756
            |.|:..:..||                                   |:|:.|..:.:|::::..
plant   681 EIKSADNCILQ-----------------------------------EQLQEKCTENKELHEKVNL 710

  Fly   757 -ERVLNGLDEDNAKPQ-----------DPF---YESQENHNLIGVANIFLEVLFHDVKLDYHTPI 806
             |:.||.:..:.:.|.           |..   .:|||..|             .::||: |..|
plant   711 LEQRLNAVSSEKSSPSCSNKAVSGEYADELKKKIQSQEIEN-------------EELKLE-HVQI 761

  Fly   807 ISQQG-----------------EVAGRLQVEIERIAGQMP----QDRMCE--------------- 835
            :.:..                 |:|....||::.:|.::.    |:...|
plant   762 VEENSGLRVQNQKLAEEASYAKELASAAAVELKNLASEVTKLSLQNTKLEKELAAARDLAQTRNP 826

  Fly   836 --------------------SVSESSGDSRDEYD-DPVD 853
                                |.|.||||..|.:: ||.|
plant   827 MNGVNRKYNDGARSGRKGRISSSRSSGDEFDAWNLDPED 865

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	140/356 (39%)
		KISc	6..359	CDD:214526	139/354 (39%)
		Kinesin_assoc	356..468	CDD:292801	23/113 (20%)
		FHA	446..546	CDD:238017	21/100 (21%)
		KIF1B	741..786	CDD:289208	12/60 (20%)
		DUF3694	<1196..1252	CDD:289256
		CAP_GLY	1786..1850	CDD:279625
AT4G39050	NP_195616.2	KISc_CENP_E	98..415	CDD:276825	137/348 (39%)
		SMC_prok_B	624..>914	CDD:274008	56/340 (16%)
		zf-C3HC4_3	1004..1049	CDD:404755
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910