DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Khc-73 and TES

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	NP_001319676.1	Gene:	TES / 823396	AraportID:	AT3G43210	Length:	938	Species:	Arabidopsis thaliana

Alignment Length:	1078	Identity:	258/1078 - (23%)
Similarity:	425/1078 - (39%)	Gaps:	311/1078 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTIL-QNPPPLEKIERKQPKTFAFDHCFYSLN 64
            :..:||.|.||:||.|.||.........|....:||: :||.|     .|.|..::||..|
plant    25 VTEEKILVTVRMRPLNWREHAKYDLIAWECPDDETIVFKNPNP-----DKAPTKYSFDKVF---- 80

  Fly    65 PEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCDQLFS 129
              :...|:|| |::...|.:..:|..|.||.|||||||.|||::||.|..||  ::..:.:.:
plant    81 --EPTCATQE-VYEGGSRDVALSALAGTNATIFAYGQTSSGKTFTMRGVTES--VVKDIYEHI-- 138

  Fly   130 AIANKSTPELMYKVEVSYMEIYNEKVHDLL--DPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQ 192
                :.|.|..:.::||.:|||||.|.|||  |..|    |::.:....|..|:.|.:..|.|.|
plant   139 ----RKTQERSFVLKVSALEIYNETVVDLLNRDTGP----LRLLDDPEKGTIVENLVEEVVESRQ 195

  Fly   193 DIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSERA 257
            .:.:|::.....|.|..|.:|.:|||||.:..:.:...|.:.| |.....::.::||||||||||
plant   196 HLQHLISICEDQRQVGETALNDKSSRSHQIIRLTIHSSLREIA-GCVQSFMATLNLVDLAGSERA 259

  Fly   258 VKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLGGNSR 322
            .:|.|.|.||||||:||:||.||..||.||   |:|:|..:   ||||||.||.:|:::||||:|
plant   260 FQTNADGLRLKEGSHINRSLLTLTTVIRKL---SSGRKRDH---VPYRDSKLTRILQNSLGGNAR 318

  Fly   323 TVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVN-EDPNARIIRELRHEVETLRSMLKHATG 386
            |.::.||||:..:.|:|..||.:|..||.:.|.|.|| .....::::.|:.:|..|.|.|:....
plant   319 TAIICTISPALSHVEQTKKTLSFAMSAKEVTNCAKVNMVVSEKKLLKHLQQKVAKLESELRSPEP 383

  Fly   387 SPVGDVQDKLAESENLMKQISQTWEEKLVKTERIQNE---RQQALEKMGISVQASGIKVEKNKYY 448
            |....::..|.|.|..::|:....:|...:.:..|:|   .::|.|:.|.|
plant   384 SSSTCLKSLLIEKEMKIQQMESEMKELKRQRDIAQSELDLERKAKERKGSS-------------- 434

  Fly   449 LVNLNADP--SLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVITIEDSGLYMEPVQ 511
                ..:|  .:...|.|:.|:.::                     |...|
plant   435 ----ECEPFSQVARCLSYHTKEESI---------------------PSKSV-------------- 460

  Fly   512 GARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNTSMCASEPQTPAQLIDYNFARDEIM 576
                                               |.|..|:.              :..:|.:.
plant   461 -----------------------------------PSSRRTAR--------------DRRKDNVR 476

  Fly   577 QNELSNDPIQTAIARLERQHEEDKQVALEKQRQEYERQFQQLRNILSPSTPYAPYAPYDPLRMGK 641
            |:..|.||  ||:.:..|        .|||.:::...:..|..:::..                :
plant   477 QSLTSADP--TALVQEIR--------LLEKHQKKLGEEANQALDLIHK----------------E 515

  Fly   642 ITPNTPTSQMRVEKWAQERDEMFRRSLGQLKTDIMRANSLVQEANFLAEEMEKKTKFSVTLQIPP 706
            :|.:....|...||.|        :.|.:::.        :|::|.|.||:....|
plant   516 VTSHKLGDQQAAEKVA--------KMLSEIRD--------MQKSNLLTEEIVVGDK--------- 555

  Fly   707 ANLSPNRRRGAFVSEPAILVKRTNSGSQIWTMEKLENKLIDMREMYQEHKERVLNGLDEDNAKPQ 771
            |||...             :.|.||..    :..||.||    |..|...:.:::....|.   |
plant   556 ANLKEE-------------INRLNSQE----IAALEKKL----ECVQNTIDMLVSSFQTDE---Q 596

  Fly   772 DPFYESQENHNLIGVANIFLEVLFHDVKLDYHTPI-ISQQGEVAGRLQVEIERIAGQMPQDRMCE 835
            .|.:.:|                   ||.....|. :|....:...::.....::|...:|....
plant   597 TPDFRTQ-------------------VKKKRLLPFGLSNSPNLQHMIRGPCSPLSGTENKDPESN 642

  Fly   836 SVSESS-----GDSRDEYDD-----------PVDPTSNQITC----RVTIKCASGLPLSLSNFVF 880
            .||.:|     |.:..:.||           ||...:|.:..    |:....|.....::.::|.
plant   643 VVSANSAPVSFGATPPKRDDNRCRTQSREGTPVSRQANSVDIKRMNRMYKNAAEENIRNIKSYVT 707

  Fly   881 --------CQYTFWGHQEMVVPVINAESTAHDQNMVFKFEHT----QDFTVTINEEFLEHCIEGA 933
                    .||.   .|.:|..|:..|  |::.....:::.|    .|:.:...|:..:
plant   708 GLKERVAKLQYQ---KQLLVCQVLELE--ANETGAASEYDATDESQMDWPLCFEEQRKQ------ 761

  Fly   934 LSIEVWG-------HRSAGFSKTKGWEVEQQQAKARSLVDRWAELSRKIEL----WVEIHELNDN 987
             .|.:|.       ||:..:...||...:|              :..::||    |:|.| |.:.
plant   762 -IIMLWHLCHISIIHRTQFYMLFKGDPADQ--------------IYMEVELRRLTWLEQH-LAEL 810

  Fly   988 GEYSPVEVTNR-NEVLTGGIYQLRQGQQ---RRVNVRV 1021
            |..||..:.:. ...:...|..|:|.::   :|||.::
plant   811 GNASPALLGDEPASYVASSIRALKQEREYLAKRVNTKL 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	140/357 (39%)
		KISc	6..359	CDD:214526	139/355 (39%)
		Kinesin_assoc	356..468	CDD:292801	23/117 (20%)
		FHA	446..546	CDD:238017	6/101 (6%)
		KIF1B	741..786	CDD:289208	10/44 (23%)
		DUF3694	<1196..1252	CDD:289256
		CAP_GLY	1786..1850	CDD:279625
TES	NP_001319676.1	KISc_CENP_E	29..348	CDD:276825	138/349 (40%)
		Smc	<364..>585	CDD:224117	62/394 (16%)
		DUF3490	755..919	CDD:403272	23/116 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910