DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc-73 and POK2

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	NP_188535.4	Gene:	POK2 / 821439	AraportID:	AT3G19050	Length:	2771	Species:	Arabidopsis thaliana

Alignment Length:	2146	Identity:	470/2146 - (21%)
Similarity:	812/2146 - (37%)	Gaps:	681/2146 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IKVAVRVRPFNRREIELD--TKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDH--CFYSLNPE 66
            :::.:||||.|..|..::  .:|: :.|..|.:....||..:        |.|||  |
plant   194 VQILIRVRPLNSMERSINGYNRCL-KQESSQCVAWIGPPETR--------FQFDHVAC------- 242

  Fly    67 DENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMG--------TQESKGIIPRL 123
              ....|||:|...|..:::|...|||:||||||||||||:|||:|        ...::|::||:
plant   243 --ETIDQETLFRVAGLPMVENCLSGYNSCIFAYGQTGSGKTYTMLGEVGDLEFKPSPNRGMMPRI 305

  Fly   124 CDQLFSAI----ANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLS 184
            .:.||:.|    .::....|.|..:.|::|||||::.|||:  |:..:|::||....|.||:.|:
plant   306 FEFLFARIQAEEESRRDERLKYNCKCSFLEIYNEQITDLLE--PSSTNLQLREDIKSGVYVENLT 368

  Fly   185 QLAVTSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLV 249
            :..|.|.|||..|:|:|:.:|.|.|||||.||||||:||:.|:.......:|  :..:.:|::||
plant   369 ECEVQSVQDILGLITQGSLNRRVGATNMNRESSRSHSVFTCVIESRWEKDST--ANMRFARLNLV 431

  Fly   250 DLAGSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLK 314
            |||||||...:||.||||||.::|||||:|||.||..|.|.:|||    .:.:|||||.||:||:
plant   432 DLAGSERQKTSGAEGDRLKEAASINKSLSTLGHVIMVLVDVANGK----PRHIPYRDSRLTFLLQ 492

  Fly   315 DNLGGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLR- 378
            |:|||||:|:::|..|||.....|||:||::|.|||.|.|:||||||.|..:: |||.::..|:
plant   493 DSLGGNSKTMIIANASPSVSCAAETLNTLKFAQRAKLIQNNAVVNEDSNEDVL-ELRRQIRLLKE 556

  Fly   379 --SMLK-----------------------------HATGSP------------------------ 388
              |:||                             |.||..
plant   557 ELSLLKRQNISRALSFGSATANFAESQVDSPSSVMHETGQQQAGNLLVYESGGCVRMSRKQLKSL 621

  Fly   389 ------------VGDVQDKL--AESENLMKQISQTWEEKLVKTE---RIQNERQQALEK-MGISV 435
                        |.|...|.  ||.|:|.:.:.|. ||....|:   |.:.::.|.||. :|..:
plant   622 EITLAGSLRREHVADASIKKLEAEIEHLNRLVRQR-EEDTRSTKMMLRFREDKIQRLESLLGNHI 685

  Fly   436 QASGI-----------------KVEKN----KYYLVNLNADPSLNELLVYYLK-DRTLIGGRTIS 478
            .|...                 |::||    ::.|.|:.....|.....:|.: :|.::.|
plant   686 SADSFLLEENNVLSEEIQLLQAKIDKNPELTRFALENIRLLDQLRRFQEFYEEGEREILLG---- 746

  Fly   479 GQQPDIQLSGL--------------------GIQP--------EHCVI----------------- 498
                  ::|.|                    ||:|        |:|.:
plant   747 ------EVSNLRNQLFQFLDENSDWQKHVDDGIEPQGASRMSKENCSLQEELKKTCYELEKCRSN 805

  Fly   499 ---TIEDSGLYMEPVQGARCFVNGSAAVEKTPLQ----NGDRILWGNHHFFRVNSPKSNNTSMCA 556
               .:|::......:...:..|:...|.  ||.:    |..:.|.|..:|      :.:.|..|.
plant   806 LGSCLEENAKLSREINDLQAMVSDIRAC--TPDEHSSVNKQKALLGTQNF------EPHETLACE 862

  Fly   557 S---------------------------EPQTPAQLI----DYNFARDEIM---------QNELS 581
            .                           ...|.||.:    |....:|:::         .:||.
plant   863 QANYVEEIIKLQLDLDVQKIILDEERTLRGDTEAQAVRLKFDIEVLKDQLLLISKQQKNVYSELG 927

  Fly   582 NDPIQTAIARLERQHEEDKQVALEKQRQEYERQFQQLR----NILSPSTPYAPYAPYDPLRMGKI 642
            .  .::|:|.||.|:....|.|:|.:|.: |..|:.|:    :|.:..:........:|....:|
plant   928 E--TKSAVAALESQNIILIQEAVELRRIK-ENYFELLKKQELDIPAMKSKQCDEFKDNPAEDSEI 989

  Fly   643 TPNTPTSQMRVEKWAQERDEMFRRSLGQLKTDIMRANSLVQEANFLAEEMEKKT-KFSVTLQIPP 706
            .......|..:|| |:..:.::       |:||.......:|.:.:.::.|..| :..|.||
plant   990 DTKFKKMQASLEK-AKRLNMLY-------KSDIASKACGDEEMDEVCKQAEAATAEVIVCLQ--- 1043

  Fly   707 ANLSPNRRRGAFVSEPAILVKRTNSGSQIWTMEKLENKLIDMREMYQEHKERVLNGLDEDNAKPQ 771
                         :|..:|.|..|   ...:.|.:..|.:::.|...|..:..|.....||.:.|
plant  1044 -------------NELEVLQKEVN---DFQSKENVTEKQVEILETQMEELQDKLRDTTMDNEQLQ 1092

  Fly   772 DPFYESQENHNLIGVANIFLEVLFHDVKLDYHTPIISQQGEVAGRLQVEIERIAGQMPQDRMCES 836
            :..  ..::..|:.::| .:|:|..:::     .|:....|.......:.:.|:|.:|..|:.
plant  1093 EQL--RGKDMELLIISN-EMELLTSELE-----EILLNGNEGLTDACYQADLISGSLPDKRIW-- 1147

  Fly   837 VSESSGDSRDEYDDPVDPTSNQITCRVTIKCASGLPLSLSNFVFCQYTFWGHQEMVVPVINAEST 901
            :||..|                           ||..:||           .:|:::
plant  1148 ISEQVG---------------------------GLIRTLS-----------ERELMI-------- 1166

  Fly   902 AHDQNMVFKFEHTQDFTVTINEEFLEHCIEGA----LSIEVWGHRSAGFSKTKGWEVEQQQAKAR 962
                                  |.||.|:|.|    ..||      :.....||..:...:|..|
plant  1167 ----------------------EDLESCLEDANKKRCDIE------SMLKSLKGAAIVMNEAHQR 1203

  Fly   963 SLVDRWAE-----------------LSRKIELWVE-IHELNDNGEYSPVEVTNRNEVLTGGIYQL 1009
            ...::..:                 |..|:::... |:|.:|....|.:.|...:||.....::|
plant  1204 EFEEKETDVLLLKSQLCTKTETILRLQEKLKMAERLIYEASDCATASLIIVNRYSEVTESHTFEL 1268

  Fly  1010 RQGQQRRVNVRVKPVQNSGTLPIICQSIVNVAIGSVTVRSRL----------QRPLDSYQEEDLT 1064
            :|..       .:..:::||:..:.|.:.::.......||:|          ::.|:..:|..::
plant  1269 KQKD-------FQVAESTGTILSLKQQVQDLEATCKEFRSKLLEEEKNASAMEQKLEEIEETSIS 1326

  Fly  1065 VLREKWSEALG-------------RRRQYLDQQ--------------------IQMLIKKEEKNE 1096
            .::||.||..|             ...:|.:.:                    :...|:|...|.
plant  1327 AMKEKLSELKGGVSDLRSCITMCQEHDKYTEAENSLSSPAHCSEGQEPGRNVVVSSCIEKTPNNN 1391

  Fly  1097 QERERELSLVHQWVSLTEERNAVLVPAPGSGIPGAPASWEPPSGMEPHVPVLFLNLNG--DDLSA 1159
            ......||     ..::.||..|::... ..:..|.||.:       .|.|...||.|  ::|.|
plant  1392 HTESMRLS-----SKVSSERGKVIILLK-QEMESALASLK-------EVQVEMANLKGEKEELKA 1443

  Fly  1160 ------QNTND-ELSVAGINSILS---KEHGHKF----YTLQILQH------LDKD------VCC 1198
                  .|.|| ...:..:|:::|   :::.||.    :.|:.|:|      ::.|      :|.
plant  1444 SEKRSLSNLNDLAAQICNLNTVMSNMEEQYEHKMEVTDHKLKTLEHEIAKMKIEADQEYVENLCI 1508

  Fly  1199 VASWDSSMHDSQ----ALNRVTEANERVYLILRTTVRLSHPAPMDLVLRKRL---------SINI 1250
            :..::.:....:    .:|.:..|||:    :|..:.......:.||..|:.         |||:
plant  1509 LKKFEEAQGTIREADITVNELVIANEK----MRFDLEKQKKRGISLVGEKKALVEKLQELESINV 1569

  Fly  1251 KKGQTLTDRLKKFRLVRGENAIWQSGVTYEVVSNIPKASEELEDRESLAQLAASGDDCSASDGET 1315
            |:.:.|....|.|     |:::...|   .:|..:.....:|:|..|:|....:.|
plant  1570 KENEKLAYLEKLF-----ESSLMGIG---NLVEELATVVRKLQDESSVALTGMAKD--------- 1617

  Fly  1316 YIEKYTRGVSAVESI-LTLDRLRQNVAVKE--------------LETAHG---QPLSMRKTVSVP 1362
             :.:....||...|. |.|:.:...:.:|:              |||..|   :...:::.:.|.
plant  1618 -LSELKSWVSETNSARLFLEDIWSEIIMKDCAISVLHLCHMGILLETVTGINTENGLLQRGLCVS 1681

  Fly  1363 NFSQIMRFDASMESLLNVGRS-ESFADLNNSALGNKFTPAGHSPAGAGGVIRSRHSFGGKGSSDD 1426
            |.|    .....::.|.:.|. |.||:|....|.:                 .::.|.....:::
plant  1682 NSS----IAGLRDNNLRLRRELEMFANLKGKLLTD-----------------IKNGFERISRNEE 1725

  Fly  1427 SPGKAFGIASPATSKLLGMRMTTLHEEPLGGHRS------LD---EEPEDSYSDSEYAAE--YEQ 1480
            :........|....|:.|::    ::|.|...||      ||   :|.:.|..|   .||  .||
plant  1726 ATNLLTTKLSSFDQKISGLQ----YQEDLMLQRSNSMGSQLDILLKEIDLSNGD---LAETLLEQ 1783

  Fly  1481 ERQQNKSMATRSRLTASKTMDSFMDVSSHSNQSYLSYTSSANANMKHLTGLATLSMSSSTSSGYG 1545
            ||..|:.             :.|.|...   |.||....|.:..         |.:.:.|:..|.
plant  1784 ERHLNQK-------------NDFFDTEV---QLYLMDLCSKDVE---------LLVLAQTAKEYS 1823

  Fly  1546 SQAVSCNNLSNEDIASMRSMSIDETPDFDRVNSNSPPNRQARVNPFLKDMPKAKIQEQPEQQAK- 1609
                ||..:.:.::       :|.                   :..::|:.:..|..|.|.:.|
plant  1824 ----SCLAVVDREL-------LDH-------------------HVIVEDLKEKLIVSQVEGELKD 1858

  Fly  1610 ------KLQEAFTHPLEQLESSQN----AQSDDDECAQ-LPKNNNNNLDLVNEPKPL-SSQTDLE 1662
                  ||:.....  |:|..:|:    ..||.|...| :.:.:..|.|.......| ||.|.|:
plant  1859 QCLVDNKLETVSVK--EELTEAQSKIKVLSSDLDRSVQKIAEIDEVNKDFGERVIFLESSITGLQ 1921

  Fly  1663 ESMSQPKSKTEFATDNQNGNRSSDELSHSSEDLLEGDGIVREELPAGKVVRRKKSNTQPPSNGNS 1727
            :.::...|  |..:...:.:.:::||     |:.|.|..|..::    |...||.|.       |
plant  1922 QELAMKAS--ELYSLEHSRSVTAEEL-----DIKERDVQVYADI----VSSLKKENV-------S 1968

  Fly  1728 INNN--NNGTTQAPRIN-HRASVAKMEGLAAYLDSSIMTSSTEVDEESKDVELVLPEWIVVGESV 1789
            :.|.  :.|..|...:: .|.|:||...|.               |:||.:|.:..:.:.:.:.:
plant  1969 LKNKFIHFGEDQFKALDVTRLSIAKCSHLT---------------EDSKKLEKLTRDGMAISDKM 2018

  Fly  1790 L 1790
            |
plant  2019 L 2019

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	157/368 (43%)
		KISc	6..359	CDD:214526	157/368 (43%)
		Kinesin_assoc	356..468	CDD:292801	41/207 (20%)
		FHA	446..546	CDD:238017	22/152 (14%)
		KIF1B	741..786	CDD:289208	8/44 (18%)
		DUF3694	<1196..1252	CDD:289256	12/68 (18%)
		CAP_GLY	1786..1850	CDD:279625	1/5 (20%)
POK2	NP_188535.4	Motor_domain	192..540	CDD:277568	160/371 (43%)
		KISc	193..537	CDD:214526	157/368 (43%)
		Kinesin-relat_1	670..755	CDD:289481	16/94 (17%)
		SMC_prok_B	<877..1606	CDD:274008	151/874 (17%)
		Smc	1410..2238	CDD:224117	144/758 (19%)
		KASH_CCD	2086..2284	CDD:291334
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	252	1.000	Domainoid score	I517
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm2548
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910