DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc-73 and AT3G10310

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	NP_001325950.1	Gene:	AT3G10310 / 820193	AraportID:	AT3G10310	Length:	969	Species:	Arabidopsis thaliana

Alignment Length:	659	Identity:	189/659 - (28%)
Similarity:	288/659 - (43%)	Gaps:	153/659 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IKVAVRVRP-FNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYSLNPEDEN 69
            |:|..|||| ||.   |:| ..|..:.|..::....|  .|..:...|||.|:..|.....:|:.
plant   364 IRVYCRVRPIFNS---EMD-GVIDYIGKDGSLFVLDP--SKPYKDARKTFQFNQVFGPTATQDDV 422

  Fly    70 FASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMG----TQESKGIIPRLCDQLFSA 130
            |...:.:.    |.::|    |||.||||||||||||:|||.|    :....||.......|| .
plant   423 FRETQPLI----RSVMD----GYNVCIFAYGQTGSGKTYTMSGPPGRSATEMGINYLALSDLF-L 478

  Fly   131 IANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLS-----QLAVTS 190
            |.::....:.|::.|..:|||||:|.|||....:...|.:|   ......||||     ..:|.|
plant   479 ICDRRKDMMTYEIYVQMVEIYNEQVRDLLAENSSCTRLDIR---TCSSDDDGLSLPDATMHSVNS 540

  Fly   191 YQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSE 255
            .:|:..||..|..:|.|::|:||..|||||::|.|   .:.....:|  |...|.:.||||||||
plant   541 TKDVLQLMEAGEVNRAVSSTSMNNRSSRSHSIFMV---HVRGKDTSG--GTLRSCLHLVDLAGSE 600

  Fly   256 RAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLGGN 320
            |..|:...||||||...|||||:.||.|||.||.:::        .:|||:|.||.||:|:|||.
plant   601 RVDKSEVTGDRLKEAQYINKSLSCLGDVISALAQKNS--------HIPYRNSKLTLLLQDSLGGQ 657

  Fly   321 SRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSMLKHAT 385
            ::|:|.|.:||..|::.||:|||::|.|.. .|...........|.:..|:.::|.    ||.|.
plant   658 AKTLMFAHLSPEEDSFGETISTLKFAQRVS-TVELGAARAHKETREVMHLKEQIEN----LKRAL 717

  Fly   386 GSPVGDVQDKLAESENLMKQISQTWEEKLVKTER---------IQN--------ERQQALEKMGI 433
            |:      ::.....|..|:|...:...:..|||         |:|        |.::.::....
plant   718 GT------EEWNNVSNGSKEIKSPFSRPIATTERTPPRLRRLSIENCSSTKANLEDRRGIKSPLA 776

  Fly   434 SVQASGIKVE-----KNKYYLVNLNADPSLNELLVYYLKD-----------RTLIGGRTISGQQP 482
            |.:|..:.:|     ||:   .|...||::.   |:.||:           ...:.|||   ..|
plant   777 SRRAQILSLEGPMSCKNE---ENGKGDPTME---VHQLKNPRSPLSSYQNRAVKVDGRT---SIP 832

  Fly   483 DIQLSGLGIQPEHCVITIEDSGLYMEPVQGAR----------CFVNGSAAVEKTPLQNGDRILWG 537
            .:|                   |...||:||.          ...||..:..:..|:...:::.|
plant   833 QLQ-------------------LLQTPVKGASRNDIQMISVDSKTNGKGSHIRKSLRTIGKLING 878

  Fly   538 N------------------HHFFRVNSPKSNNTSMCASEPQT----PAQLIDYNFARDEIMQNEL 580
            :                  ::|..:.||.::|......:..|    |.|        :...::.:
plant   879 SEKRKENIPADPRSPLGVANNFSHIKSPDTSNAKTMRRQSLTGVMPPGQ--------ERSRRSSI 935

  Fly   581 SNDPIQTAI 589
            ...||:..:
plant   936 GGKPIENGV 944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	139/362 (38%)
		KISc	6..359	CDD:214526	139/362 (38%)
		Kinesin_assoc	356..468	CDD:292801	26/133 (20%)
		FHA	446..546	CDD:238017	21/138 (15%)
		KIF1B	741..786	CDD:289208
		DUF3694	<1196..1252	CDD:289256
		CAP_GLY	1786..1850	CDD:279625
AT3G10310	NP_001325950.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910