Protein Alignment Khc-73 and KIF18A

DIOPT Version :10

• Sequence 1: NP_001261000.1
• Gene: Khc-73 / 36718
• FlyBaseID: FBgn0019968
• Length: 1957
• Species: Drosophila melanogaster
• Sequence 2: NP_112494.3
• Gene: KIF18A / 81930
• HGNCID: 29441
• Length: 898
• Species: Homo sapiens
• Alignment Length: 862
• Identity: 253/862 - (29%)
• Similarity: 378/862 - (43%)
• Gaps: 165/862 - (19%)

  Fly     6 IKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLE------------KIERKQPK--TFAF 56
            :||.|||||.|.:|.......:|.:..:..::.:|...|            .:.:||.|  .|.|
Human    12 MKVVVRVRPENTKEKAAGFHKVVHVVDKHILVFDPKQEEVSFFHGKKTTNQNVIKKQNKDLKFVF 76

  Fly    57 DHCFYSLNPEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIP 121
            |..|      ||. ::|..||:...:.||.:...|||..:.|||.||:||::||:|:.:..|::.
Human    77 DAVF------DET-STQSEVFEHTTKPILRSFLNGYNCTVLAYGATGAGKTHTMLGSADEPGVMY 134

  Fly   122 RLCDQLFSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQL 186
            .....|:..: ::...|.:....|||:|:|||::.|||   .|...|.|||....|..|.||:..
Human   135 LTMLHLYKCM-DEIKEEKICSTAVSYLEVYNEQIRDLL---VNSGPLAVREDTQKGVVVHGLTLH 195

  Fly   187 AVTSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVS-GEKVSRMSLVD 250
            ...|.::|.:|:..|||:||...|:|||.||||||||.:.|.|  .|:...:: ..::::|||:|
Human   196 QPKSSEEILHLLDNGNKNRTQHPTDMNATSSRSHAVFQIYLRQ--QDKTASINQNVRIAKMSLID 258

  Fly   251 LAGSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKD 315
            |||||||..:||.|.|..||:|||:||..||.||:.|||...     .::.:|||:|.||.||||
Human   259 LAGSERASTSGAKGTRFVEGTNINRSLLALGNVINALADSKR-----KNQHIPYRNSKLTRLLKD 318

  Fly   316 NLGGNSRTVMVATISPSADNYEETLSTLRYADRAKRI----------VNHAVVNEDPNARIIREL 370
            :||||.:|:|:|.:|||:..|::|.:||:||:|||.|          ||:.:..   ..:|..|.
Human   319 SLGGNCQTIMIAAVSPSSVFYDDTYNTLKYANRAKDIKSSLKSNVLNVNNHITQ---YVKICNEQ 380

  Fly   371 RHEVETLRSMLK----HATGSPVGDVQDKLAESENLMKQISQTWE-------------------E 412
            :.|:..|:..||    ....:...| |.||..|....|:|.:..|                   |
Human   381 KAEILLLKEKLKAYEEQKAFTNEND-QAKLMISNPQEKEIERFQEILNCLFQNREEIRQEYLKLE 444

  Fly   413 KLVKTERIQNERQQALEKMGISVQASGIKVE----KNKYYLVNLNADPSLNELLVYYLKDRTLIG 473
            .|:|...:::..||...|. |.:..|..|||    |..:.|..|....|       ||:.|
Human   445 MLLKENELKSFYQQQCHKQ-IEMMCSEDKVEKATGKRDHRLAMLKTRRS-------YLEKR---- 497

  Fly   474 GRTISGQQPDIQLSGLGIQPEHCVITIEDSGLYMEPVQGARCFVNGSAAVE-KTPLQNGDRILWG 537
             |....:|.|...:.|     |.|  .::.||..:         ||....| |..|.
Human   498 -REEELKQFDENTNWL-----HRV--EKEMGLLSQ---------NGHIPKELKKDLH-------- 537

  Fly   538 NHHFFRVNSP-KSNNTSM----CASEP---QTPAQL------IDYNFARDEIMQNELSNDPIQTA 588
            .||....|.. |:....|    |..|.   ||.|.|      :...:.  .:.:..|||...::.
Human   538 CHHLHLQNKDLKAQIRHMMDLACLQEQQHRQTEAVLNALLPTLRKQYC--TLKEAGLSNAAFESD 600

  Fly   589 IARLERQHEEDKQVALEKQRQEYERQFQQLRNILSPSTPYAPYAPYDPLRMGKITPNTPTSQMRV 653
            ...:|...|..|.|....|..|..:| ..|..| |....:....|..|:.....:..|...::..
Human   601 FKEIEHLVERKKVVVWADQTAEQPKQ-NDLPGI-SVLMTFPQLGPVQPIPCCSSSGGTNLVKIPT 663

  Fly   654 EKWAQERDEMFRRSL-GQ--LKTDIMRANSLVQEANFLAEEMEKKTKFSVTLQIPPANLSPNRRR 715
            ||  :.|.::....| ||  ||:.   .:..||..:.|::|::            |...:|...|
Human   664 EK--RTRRKLMPSPLKGQHTLKSP---PSQSVQLNDSLSKELQ------------PIVYTPEDCR 711

  Fly   716 GAFVSEPAILVKR----TNSGSQIWTMEKLENKLIDMREMYQEHKERVLNG---LD------ED- 766
            .||.:...:.:.:    |.|...|.:....:|.|..:.|:...|..|...|   ||      ||
Human   712 KAFQNPSTVTLMKPSSFTTSFQAISSNINSDNCLKMLCEVAIPHNRRKECGQEDLDSTFTICEDI 776

  Fly   767 -NAKPQDPFYESQENHN 782
             ::|.:.|..||..|.|
Human   777 KSSKCKLPEQESLPNDN 793

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	145/377 (38%)
		Kinesin_assoc	356..468	CDD:465047	31/138 (22%)
		FHA_KIF13	446..547	CDD:438758	22/101 (22%)
		KIF1B	741..786	CDD:463574	16/53 (30%)
		DUF3694	989..1243	CDD:463599
		CAP_GLY	1785..1850	CDD:460154
KIF18A	NP_112494.3	KISc_KIP3_like	11..355	CDD:276821	142/360 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	667..690		6/25 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	830..871