DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc-73 and si:dkey-26i13.8

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	XP_001337836.4	Gene:	si:dkey-26i13.8 / 797363	ZFINID:	ZDB-GENE-090312-134	Length:	991	Species:	Danio rerio

Alignment Length:	1006	Identity:	270/1006 - (26%)
Similarity:	421/1006 - (41%)	Gaps:	260/1006 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KIKVAVRVRPFNRREIELDTKCIV-EMEKQQTILQNP----PPLEKIERKQPKTFAFDHCFYSLN 64
            ::.||:|:||.|..|||.....:. :::.|..:|.:|    ..:.:..|.:.||:.||..|
Zfish    12 QLTVALRIRPLNEAEIEEGATIVAHKIDNQMVVLMDPCEDSDNVLRAHRSREKTYMFDLAF---- 72

  Fly    65 PEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCDQLFS 129
               :..|:||.|:....:.::|....||||.:||||.||:||::||:|.....||..|..:.||.
Zfish    73 ---DYTATQEDVYVATTKNLIDGVIAGYNATVFAYGPTGAGKTHTMLGLDSEPGIYIRTLNDLFR 134

  Fly   130 AIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQDI 194
            ||.: ||.:|...|.:||:|||||.:.|||:  |:...|::||.......:.|:::.:..:.::|
Zfish   135 AIED-STEDLDCSVYMSYIEIYNEMIRDLLN--PSSGYLELREDGKGEIRIAGITEFSTCNAKEI 196

  Fly   195 DNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGE-KVSRMSLVDLAGSERAV 258
            ..|:|:|||.||..:|..|..||||||:..|.:.|  ..:...::.| :|.::.:|||||:|||.
Zfish   197 MALLTKGNKQRTQESTAANKTSSRSHAILQVTVKQ--KSRVKDINEEVRVGKLFMVDLAGTERAS 259

  Fly   259 KTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLGGNSRT 323
            :|...|.|:|||::||:||..|...|:.|::: .||.:   :||.||||.||.||||.|||||||
Zfish   260 QTQNRGKRMKEGAHINRSLLALANCINALSEK-GGKGA---QFVNYRDSKLTRLLKDALGGNSRT 320

  Fly   324 VMVATISPSADNYEETLSTLRYADRAKRI---VNHAVVNEDPN----ARIIRELRHEVETLRSML 381
            ||:..|||::.|:||:.:||.|||:||.|   |...::|...:    .|||.:||.|:|.||:.:
Zfish   321 VMITHISPASSNFEESRNTLVYADKAKNIRTKVKRNLMNVSYHLAQYTRIIADLRSEIERLRAKI 385

  Fly   382 KHATGSPVGDVQDKL----AESENLMKQISQ-------TWEEKLVKTERIQNERQQAL------- 428
            ...:       ||:|    |:..|:..::.|       ..:|:|:...|.|.|.:::|
Zfish   386 DQQS-------QDQLKGEKADIRNIQAEVQQYSHGEMALLQEQLLSAFREQMEIRRSLMELENCN 443

  Fly   429 --------------------------EKMGISVQASGIKVEKNK-------YYLVNLNAD--PSL 458
                                      ||..:|.|......|:.:       .|:.....:  |.|
Zfish   444 MELHIDTSRHLLTISDWERDRARARREKDELSGQKKHTDKEEEQESMPEEPQYVTAAREEIGPLL 508

  Fly   459 NE--------------LLVYYLKD---RTLIGGRTISGQQPDI----------QLSGLGIQ---- 492
            .|              ||...||.   ..|:..|..:.:|.||          :|....||
Zfish   509 AEQRKTMELKRELEEKLLNMKLKSSKIEELLPKRISNTEQRDILMLLCKVHELELEKTEIQSAVL 573

  Fly   493 -PEHCVIT-------------------------IEDSGLYM-EPVQGARCFVNGSAAVEKTPLQN 530
             .|:.:.|                         |||.||.: |.:|.......|.       |.:
Zfish   574 CKENVLRTKDFIIQRHEQQRTLCDDIIHQQKMLIEDQGLCVPEGLQELYSLYFGE-------LSD 631

  Fly   531 G--DRILWGNHHFFRVNSPKSNNTSMCASEPQTPAQLIDYNFARDEIMQNELSNDPIQTAIARLE 593
            |  |:||  |.|.|..|:..:.         |....:|......|:..|:.:...|:.
Zfish   632 GIIDQIL--NLHTFTTNNLNAR---------QLRLDVISNLEEADKAEQSNVKFSPLD------- 678

  Fly   594 RQHEED----------------KQVALEKQRQEYERQFQQ--LRNI--LSPSTPYAPYAPYDPLR 638
             :|..|                |.::..|.|:::.....|  :|.:  :..|||..|.....|..
Zfish   679 -KHPRDSSSSGLDYDSDTNRVFKSLSKIKPRRQHHSSSSQTLMRKVCAVKDSTPICPTESVSPDT 742

  Fly   639 MGKITPNTPTSQMRVEKWAQERDEMFRRSLGQLKTDIMRANSLVQEANFLAEEMEKKTKFSVTLQ 703
            :.:|..:|.:..:...|         |||..|.|     :||.:......|......:..|:...
Zfish   743 LREIVSDTKSISVIAAK---------RRSRLQAK-----SNSRMAGMGLAAGLKSSVSMDSLVST 793

  Fly   704 IP--PANLSPNRRRGAFVSEPAILVKRTNSGSQIWTMEKLENKLIDMREMYQEHKE--RVLNGLD 764
            :|  .|.:..:.:|....|:.....|||...:::  .||            |:||:  |......
Zfish   794 LPDESAEVRRSHQRHGGSSQSKQDPKRTEGRTEL--PEK------------QQHKKRSRSFEASK 844

  Fly   765 EDNAKPQD-----PFYES-QENH------NLI-----GVAN---------------IFLEVLFHD 797
            ....||:.     |..|| .:||      |:|     |.||               ...||.|..
Zfish   845 RQVQKPRQNASRYPALESISDNHLVRPALNIIQPLNGGPANPATPPVAKVKIPVSHFTGEVQFQK 909

  Fly   798 VKLDYHTP-IISQQGEVAGRLQVEIERIAGQ 827
            :::....| .|.|:.....|.|...:|..||
Zfish   910 LEIRGTPPSTIHQKHSDTKRAQAVYKRQRGQ 940

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	143/362 (40%)
		KISc	6..359	CDD:214526	143/361 (40%)
		Kinesin_assoc	356..468	CDD:292801	34/182 (19%)
		FHA	446..546	CDD:238017	34/168 (20%)
		KIF1B	741..786	CDD:289208	13/63 (21%)
		DUF3694	<1196..1252	CDD:289256
		CAP_GLY	1786..1850	CDD:279625
si:dkey-26i13.8	XP_001337836.4	KISc	12..356	CDD:214526	143/359 (40%)
si:dkey-26i13.8	XP_001337836.4	KISc_KIP3_like	12..349	CDD:276821	141/352 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910