Protein Alignment Khc-73 and si:dkey-26i13.8

DIOPT Version :10

• Sequence 1: NP_001261000.1
• Gene: Khc-73 / 36718
• FlyBaseID: FBgn0019968
• Length: 1957
• Species: Drosophila melanogaster
• Sequence 2: XP_009304780.1
• Gene: si:dkey-26i13.8 / 797363
• ZFINID: ZDB-GENE-090312-134
• Length: 991
• Species: Danio rerio
• Alignment Length: 1006
• Identity: 270/1006 - (26%)
• Similarity: 421/1006 - (41%)
• Gaps: 260/1006 - (25%)

  Fly     5 KIKVAVRVRPFNRREIELDTKCIV-EMEKQQTILQNP----PPLEKIERKQPKTFAFDHCFYSLN 64
            ::.||:|:||.|..|||.....:. :::.|..:|.:|    ..:.:..|.:.||:.||..|
Zfish    12 QLTVALRIRPLNEAEIEEGATIVAHKIDNQMVVLMDPCEDSDNVLRAHRSREKTYMFDLAF---- 72

  Fly    65 PEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCDQLFS 129
               :..|:||.|:....:.::|....||||.:||||.||:||::||:|.....||..|..:.||.
Zfish    73 ---DYTATQEDVYVATTKNLIDGVIAGYNATVFAYGPTGAGKTHTMLGLDSEPGIYIRTLNDLFR 134

  Fly   130 AIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQDI 194
            ||.: ||.:|...|.:||:|||||.:.|||:  |:...|::||.......:.|:::.:..:.::|
Zfish   135 AIED-STEDLDCSVYMSYIEIYNEMIRDLLN--PSSGYLELREDGKGEIRIAGITEFSTCNAKEI 196

  Fly   195 DNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGE-KVSRMSLVDLAGSERAV 258
            ..|:|:|||.||..:|..|..||||||:..|.:.|  ..:...::.| :|.::.:|||||:|||.
Zfish   197 MALLTKGNKQRTQESTAANKTSSRSHAILQVTVKQ--KSRVKDINEEVRVGKLFMVDLAGTERAS 259

  Fly   259 KTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLGGNSRT 323
            :|...|.|:|||::||:||..|...|:.|::: .||.:   :||.||||.||.||||.|||||||
Zfish   260 QTQNRGKRMKEGAHINRSLLALANCINALSEK-GGKGA---QFVNYRDSKLTRLLKDALGGNSRT 320

  Fly   324 VMVATISPSADNYEETLSTLRYADRAKRI---VNHAVVNEDPN----ARIIRELRHEVETLRSML 381
            ||:..|||::.|:||:.:||.|||:||.|   |...::|...:    .|||.:||.|:|.||:.:
Zfish   321 VMITHISPASSNFEESRNTLVYADKAKNIRTKVKRNLMNVSYHLAQYTRIIADLRSEIERLRAKI 385

  Fly   382 KHATGSPVGDVQDKL----AESENLMKQISQ-------TWEEKLVKTERIQNERQQAL------- 428
            ...:       ||:|    |:..|:..::.|       ..:|:|:...|.|.|.:::|
Zfish   386 DQQS-------QDQLKGEKADIRNIQAEVQQYSHGEMALLQEQLLSAFREQMEIRRSLMELENCN 443

  Fly   429 --------------------------EKMGISVQASGIKVEKNK-------YYLVNLNAD--PSL 458
                                      ||..:|.|......|:.:       .|:.....:  |.|
Zfish   444 MELHIDTSRHLLTISDWERDRARARREKDELSGQKKHTDKEEEQESMPEEPQYVTAAREEIGPLL 508

  Fly   459 NE--------------LLVYYLKD---RTLIGGRTISGQQPDI----------QLSGLGIQ---- 492
            .|              ||...||.   ..|:..|..:.:|.||          :|....||
Zfish   509 AEQRKTMELKRELEEKLLNMKLKSSKIEELLPKRISNTEQRDILMLLCKVHELELEKTEIQSAVL 573

  Fly   493 -PEHCVIT-------------------------IEDSGLYM-EPVQGARCFVNGSAAVEKTPLQN 530
             .|:.:.|                         |||.||.: |.:|.......|.       |.:
Zfish   574 CKENVLRTKDFIIQRHEQQRTLCDDIIHQQKMLIEDQGLCVPEGLQELYSLYFGE-------LSD 631

  Fly   531 G--DRILWGNHHFFRVNSPKSNNTSMCASEPQTPAQLIDYNFARDEIMQNELSNDPIQTAIARLE 593
            |  |:||  |.|.|..|:..:.         |....:|......|:..|:.:...|:.
Zfish   632 GIIDQIL--NLHTFTTNNLNAR---------QLRLDVISNLEEADKAEQSNVKFSPLD------- 678

  Fly   594 RQHEED----------------KQVALEKQRQEYERQFQQ--LRNI--LSPSTPYAPYAPYDPLR 638
             :|..|                |.::..|.|:::.....|  :|.:  :..|||..|.....|..
Zfish   679 -KHPRDSSSSGLDYDSDTNRVFKSLSKIKPRRQHHSSSSQTLMRKVCAVKDSTPICPTESVSPDT 742

  Fly   639 MGKITPNTPTSQMRVEKWAQERDEMFRRSLGQLKTDIMRANSLVQEANFLAEEMEKKTKFSVTLQ 703
            :.:|..:|.:..:...|         |||..|.|     :||.:......|......:..|:...
Zfish   743 LREIVSDTKSISVIAAK---------RRSRLQAK-----SNSRMAGMGLAAGLKSSVSMDSLVST 793

  Fly   704 IP--PANLSPNRRRGAFVSEPAILVKRTNSGSQIWTMEKLENKLIDMREMYQEHKE--RVLNGLD 764
            :|  .|.:..:.:|....|:.....|||...:::  .||            |:||:  |......
Zfish   794 LPDESAEVRRSHQRHGGSSQSKQDPKRTEGRTEL--PEK------------QQHKKRSRSFEASK 844

  Fly   765 EDNAKPQD-----PFYES-QENH------NLI-----GVAN---------------IFLEVLFHD 797
            ....||:.     |..|| .:||      |:|     |.||               ...||.|..
Zfish   845 RQVQKPRQNASRYPALESISDNHLVRPALNIIQPLNGGPANPATPPVAKVKIPVSHFTGEVQFQK 909

  Fly   798 VKLDYHTP-IISQQGEVAGRLQVEIERIAGQ 827
            :::....| .|.|:.....|.|...:|..||
Zfish   910 LEIRGTPPSTIHQKHSDTKRAQAVYKRQRGQ 940

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	143/362 (40%)
		Kinesin_assoc	356..468	CDD:465047	34/182 (19%)
		FHA_KIF13	446..547	CDD:438758	35/169 (21%)
		KIF1B	741..786	CDD:463574	13/63 (21%)
		DUF3694	989..1243	CDD:463599
		CAP_GLY	1785..1850	CDD:460154
si:dkey-26i13.8	XP_009304780.1	KISc_KIP3_like	12..349	CDD:276821	141/352 (40%)