DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Khc-73 and kif1c

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	XP_031755447.1	Gene:	kif1c / 779557	XenbaseID:	XB-GENE-997155	Length:	1105	Species:	Xenopus tropicalis

Alignment Length:	989	Identity:	376/989 - (38%)
Similarity:	532/989 - (53%)	Gaps:	205/989 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQP----KTFAFDHCFY 61
            ||...:||||||||||.|||..|.||:::|:...|.:.||        |||    |.|.||:.::
Frog     1 MAGASVKVAVRVRPFNSREIAHDAKCVIQMQGNTTCISNP--------KQPKDSAKNFTFDYSYW 57

  Fly    62 S-LNPEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESK--GIIPRL 123
            | ...||.|||||..|:..:|..:|.:||:|||.||||||||||||||||||..||:  ||||:|
Frog    58 SHTTAEDPNFASQCQVYKDIGEEMLLHAFEGYNVCIFAYGQTGSGKSYTMMGKPESEQHGIIPQL 122

  Fly   124 CDQLFSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAV 188
            |:.||:.::...:|:|...|||||||||.|:|.|||:|| :|.:|:||||.:|||||:.||:|||
Frog   123 CEDLFARVSANRSPDLSCSVEVSYMEIYCERVRDLLNPK-SKGNLRVREHPIMGPYVEDLSKLAV 186

  Fly   189 TSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAG 253
            |||.||.:||..|||:|||||||||..||||||||::|.||...|:.|.:..||||::|||||||
Frog   187 TSYHDIADLMDCGNKARTVAATNMNETSSRSHAVFTIVFTQKRHDEMTNLDTEKVSKISLVDLAG 251

  Fly   254 SERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLG 318
            ||||..|||.|.|||||:||||||||||.|||.||:..|.||..:  |:|||||.||||||:|||
Frog   252 SERADSTGAKGTRLKEGANINKSLTTLGKVISALAEMQNKKKKSD--FIPYRDSALTWLLKENLG 314

  Fly   319 GNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSMLKH 383
            |||||.|:|.:||:..||||||||||||||||:|..:||:|||||||:||||:.||..||.:| :
Frog   315 GNSRTAMIAALSPADINYEETLSTLRYADRAKQIKCNAVINEDPNARLIRELKEEVARLRQLL-Y 378

  Fly   384 ATG--------------------SPVG-----------------------------------DVQ 393
            :.|                    :||.                                   :..
Frog   379 SQGLEDIVIDDSASAPHPPSPAAAPVSPPPLPGSLAPLASPTQNGQSEPFPEGEDAAEICTEEAM 443

  Fly   394 DKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQASGIKV----EKNKYYLVNLNA 454
            ::|.|:|.::.::::||||||.|||.::.||:..|.:||::|:..|..|    .|...:|||||.
Frog   444 ERLQETEKIIAELNETWEEKLRKTEALRTEREALLAEMGVAVREDGGTVGVFSPKKIPHLVNLNE 508

  Fly   455 DPSLNELLVYYLKDRTLIGGRTISGQ-QPDIQLSGLGIQPEHCVITIE--DSG---LYMEPVQGA 513
            ||.::|.|:|::|:     |.|..|| :.||:|||..|:.:||:...:  .||   :.:||.:||
Frog   509 DPLMSECLLYHIKE-----GITRVGQVEVDIKLSGQFIKEQHCLFHCDTNPSGEVIVTLEPCEGA 568

  Fly   514 RCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPK----SNNTSMCASEPQTPAQLIDYNFARDE 574
            ..:|||....:...|::|.||:.|.:|.||.|.|:    ....|..|.|  .|::.:|:|||:.|
Frog   569 ETYVNGKLVTQALVLKSGTRIVMGKNHVFRFNHPEQARLERERSSAAIE--NPSEPVDWNFAQKE 631

  Fly   575 IMQNELSNDPIQTAIARLERQHE-EDKQVALEKQRQEYERQFQQLRNILSPSTPYAPYAPYDPLR 638
            :::.       |....:||.:.. :|.:...:|:::|.:...:|.|          .||..|
Frog   632 LLEK-------QGIDIKLEMEKRLQDLEYQYKKEKEEADLTLEQQR----------LYADSD--- 676

  Fly   639 MGKITPNTPTSQMRVEKWAQERDEMFRRSLGQLKTDIM--RANSLVQEANFLAEEMEKKTKFSVT 701
                :.:....:...|.|         |.:..|:..:.  |..|:|:... |....:|:....|
Frog   677 ----SGDDSDKRSCEESW---------RLISSLREKVPAGRVQSIVRRCG-LPSSGKKREPIRV- 726

  Fly   702 LQIPPANLSPNRRRGAFVSEPAIL---------VKR----------TNSGSQIWTMEKLENKLID 747
            .|||     ..||.|   .:|..|         ||.          .:|..:|..|     .:|.
Frog   727 YQIP-----QRRRLG---KDPRWLTLADLKMQAVKEICYEVALNDFKHSRQEIEAM-----SVIK 778

  Fly   748 MREMYQEHKERVLNGLDEDNAKPQDPF------YESQENHNLIGVANIFLEV-----LFHDVKLD 801
            |:|:.:.:.:|.:|..:...|..:|.:      .|.....::.||.::...:     :..:|||.
Frog   779 MKELCRTYGKRDINEKELWKAVARDVWDTVGVGEEDAGTKSVSGVQDLKAHIDKLTDILQEVKLQ 843

  Fly   802 YHTPIISQQGEVAGRLQ---VEIERIAGQMP-------QDRMCE-----------SVSESSGDSR 845
            .     :.:.|....|:   :::||:   ||       :|.:.|           .:.|.||...
Frog   844 N-----NMKDEEIRSLRDRMIKMERV---MPLAQDNGDEDYLDEQSLPWYSNENQEIPEPSGSGL 900

  Fly   846 DEYDDPVDPTSNQI 859
            .....|.:|..:|:
Frog   901 SPDHSPKEPRVDQL 914

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	222/361 (61%)
		KISc	6..359	CDD:214526	222/359 (62%)
		Kinesin_assoc	356..468	CDD:292801	52/170 (31%)
		FHA	446..546	CDD:238017	40/105 (38%)
		KIF1B	741..786	CDD:289208	8/50 (16%)
		DUF3694	<1196..1252	CDD:289256
		CAP_GLY	1786..1850	CDD:279625
kif1c	XP_031755447.1	KISc_KIF1A_KIF1B	4..355	CDD:276816	222/361 (61%)
		Kinesin_assoc	352..524	CDD:406567	53/177 (30%)
		FHA	501..601	CDD:238017	40/104 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010