DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc-73 and kif21b

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	XP_009304054.2	Gene:	kif21b / 570502	ZFINID:	ZDB-GENE-130530-537	Length:	1669	Species:	Danio rerio

Alignment Length:	1683	Identity:	370/1683 - (21%)
Similarity:	616/1683 - (36%)	Gaps:	559/1683 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYSLNPEDENF 70
            :||::|:||...:|         ::|.........|...::...:.|.|.:|..|       :..
Zfish     9 VKVSLRIRPQMAKE---------KIEGCHICTSVTPGEPQVLLGKDKAFTYDFVF-------DLD 57

  Fly    71 ASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGT-------QESKGIIPRLCDQLF 128
            |.|:.::......:::..|:||||.:||||||||||:|| |||       ::.:|||||...|||
Zfish    58 AHQQQIYSACVHKLIEGCFEGYNATVFAYGQTGSGKTYT-MGTGFDVSVSEDEQGIIPRAVHQLF 121

  Fly   129 SAIANK-------STPELMYKVEVSYMEIYNEKVHDLLD------PKPNKQSLKVREHNVMGPYV 180
            ..|..:       ..|...:||...::|:|||::.||.|      .:..|.::|:.|....|.|.
Zfish   122 QGIQKRRLEAQSADIPPPDFKVSAQFLELYNEEILDLFDSTRDPEARGRKSNIKIHEDGSGGIYT 186

  Fly   181 DGLSQLAVTSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVL--------TQILTDQATG 237
            .|::...|:|..::...:..|..|||.|:|.|||:||||||:|::.|        .|::..:..|
Zfish   187 TGVTSRLVSSEDELLQCLKLGALSRTTASTQMNAQSSRSHAIFTIHLCQMRVCPQPQLVNGELNG 251

  Fly   238 VSGEKVS---------RMSLVDLAGSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNG 293
            ||...:|         :...||||||||..:|||.|:|.:||.:||..|..||.|||.|.|||
Zfish   252 VSDGSMSQSEYETLSAKFHFVDLAGSERLKRTGATGERAREGISINCGLLALGNVISALGDQS-- 314

  Fly   294 KKSGNDKFVPYRDSVLTWLLKDNLGGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVV 358
            |::|:   ||||||.||.||:|:|||||||||:|.:|||..::.|||:||:||:||:.|.|..:|
Zfish   315 KRAGH---VPYRDSKLTRLLQDSLGGNSRTVMIACVSPSDRDFMETLNTLKYANRARNIKNKVIV 376

  Fly   359 NEDPNARIIRELRHEVETLR-SMLKHATGSPVGDVQDKLAESENLMKQISQTWEEKLVKTERIQN 422
            |:|..::.|..||.|:..|: .::::..|.       ::|..|.     |:.:.:...:...:|.
Zfish   377 NQDKTSQQISALRAEIARLQMEIMEYKAGK-------RVACDEG-----SEGFSDLFQENSMLQR 429

  Fly   423 ERQQALEKMGISVQASGIKVEKNKYYLVNLNADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLS 487
            |                                   |:.|...:|
Zfish   430 E-----------------------------------NDTLRMRVK-------------------- 439

  Fly   488 GLGIQPEHCVITIEDSGLYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNT 552
                                              |:::|.          :|...||....:|..
Zfish   440 ----------------------------------AMQETI----------DHLNTRVTQLLTNGV 460

  Fly   553 SMCASEPQTPAQLIDYNFARDEIMQNELSNDPIQTAIARLERQHEEDKQVALEKQRQEYERQFQQ 617
            ::.                   :.:...:|:.|...|....|:.||     |..:..|.|...:.
Zfish   461 NLL-------------------LTKTGETNEEIGNLIQNYIREIEE-----LRSKLLESEAMNES 501

  Fly   618 LRNILSPSTPYAPYAPYDPLRMGKITPNTPTSQMRVEKWAQERDEMFRRSLGQLKTDIMRANSLV 682
            ||..||..:..:||....|  ......::|:..|..|                 .||::|
Zfish   502 LRRSLSHLSSRSPYPASHP--SAPSIGSSPSVSMEAE-----------------MTDVIR----- 542

  Fly   683 QEANFLAEEMEKKTKFSVTLQIPPANLSPNRRRGAFVSEPAILVKRT-----NSGSQIWTMEKLE 742
             :|....|.::||.:       .....||.:.:|        |.||.     :||      .|.|
Zfish   543 -QAKLDVERLKKKER-------NQRRKSPEKEKG--------LKKRAKLHPEDSG------VKSE 585

  Fly   743 NKLIDMREMYQEHKERVLNG-LDEDNAKPQDPFYESQE-NHNLIGVANIFLEVLFHDVKLDYHTP 805
            |.|      .:.::||..|| .|.||...:|..|..|| :|...|...
Zfish   586 NGL------NRANEERRENGDGDSDNEPEEDGMYPLQEDDHGESGCDE----------------- 627

  Fly   806 IISQQGEVAGRLQVEIERIAGQMPQDRMCESVSESSGDSRDEYDDPVDPTSN--QITCRVTIKCA 868
              .::.|...|.:.|.:.              .||..||..:.|:.|:..::  .:||.:.||
Zfish   628 --EEEEEEETREEEEFDS--------------DESLVDSDSDNDEKVNLQADLADLTCEIEIK-- 674

  Fly   869 SGLPLSLSNFVFCQYTFWGHQEMVVPVINAESTAHDQNMVFKFEHTQDFTVTINEEFLEHCI--- 930
                                                |.::.:.|::|...:|:..::.|..|
Zfish   675 ------------------------------------QRLIDELENSQRRLLTLKSQYEEKLILLQ 703

  Fly   931 --------------EGALSIEVWGHRSAGFSKTKGWEVEQQQAKARSLVDRWAELSR---KIELW 978
                          ...:|:|       .:::.|..:|:.:..|      |..|::|   |::..
Zfish   704 NKIRDTQLERDRVLHNLMSME-------NYTEEKASKVKSEYEK------RLKEMNRDLLKLQAA 755

  Fly   979 VEIHE--LNDNGEYS------PVEVTNRNEVLTGGIYQLRQGQQRRVNVRVKPVQNSGTLPIICQ 1035
            .:.|.  |.:.|.|.      ..||....:.....:.|:::.||||..:..|.
Zfish   756 QKEHARLLKNQGRYERELKKLQSEVAEMKKAKVALMKQMKEEQQRRRMIDAKR------------ 808

  Fly  1036 SIVNVAIGSVTVRSRLQ----RPLDSYQEEDLTVLREKWSE--ALGRRRQYLDQQIQMLIKKE-- 1092
               |..|..:....|.|    |.|:|.:.:...|||.|..|  ||.|..:.|.::....:.:.
Zfish   809 ---NREIAQLKKEQRRQEYQIRALESQKRQQELVLRRKTQEVTALRRLAKPLSERAAGRVSRRLT 870

  Fly  1093 ---------------EKNEQEREREL-SLVHQWVSLTEERNAVLVPAPGSGIPGAPASWEPPSGM 1141
                           ..:|.|..|.: |::..|       |..|     :|..|...|..|.:.|
Zfish   871 SVDSGAELSTSTTTTTSSEPESSRSVSSIIRHW-------NTKL-----NGYLGETDSHAPAANM 923

  Fly  1142 EPHVPVLFLNLNGDDLSAQNTNDELSVAGINSILSKEHGHKFYTLQILQHLDKDVCCVASWDSSM 1206
                              .::..:....|.:|..||....|:      |.|::.:..:
Zfish   924 ------------------ASSRKKFQRKGPSSGFSKTARQKW------QSLERRIMDI------- 957

  Fly  1207 HDSQALNRVTEANERVYLILRTTVRLSHPAPMDLVLRKRLSINIKKGQTLTDRLK----KFRLVR 1267
                .:.|:|..|..              |.||.:::||..:::::...|..|.|    .||...
Zfish   958 ----VMQRMTITNVE--------------ADMDRLIKKREELSVQQEALLRKREKLLSESFREED 1004

  Fly  1268 GENAIWQSGVTYEVV-SNIPKASEELED-RESLAQLAASGDD------------CSASDGETYIE 1318
            .|..:.:.....||: :||...|:.|.| :.::.|:..:.|:            ||.::..:.::
Zfish  1005 EERLLQEMNEEIEVLNANIDYISDSLSDCQATIVQIEETKDELDSVDTSVVISSCSLAEARSLLD 1069

  Fly  1319 KYTRGVSAVESILTLDRLRQNVAVKE--LETAHGQPLSMRKTVSVPNFSQIMRFDA--------- 1372
            .:.:.        ::|:..| ||.||  :....||   :|:|..:.:....|..||
Zfish  1070 YFLKA--------SIDKGLQ-VAQKEAQIRLLEGQ---LRQTDVIGSSHNHMILDALREKAECIP 1122

  Fly  1373 SMESLL-NVGRSESFADLNNSALGNKFTPAGHSPAGAGGVIRSRHSF----------GGKGSSDD 1426
            .:::|: ||.:...:|..:...  ::|:.|..|......:..|:..|          ..|..|.:
Zfish  1123 ELQALIHNVQQENGYASTDEEV--SEFSQASESGFSQMKLSASQDDFKMKVEPRLSAQMKAVSAE 1185

  Fly  1427 SPGKAFGIASPATSKLLGMRMTTLHEE-------------------PLGGH------RSLDEEP- 1465
            ..|....:.|...:|.|. .::.:.|.                   |:.||      |..|..|
Zfish  1186 YLGPILDLNSKNITKSLA-SLSEIQENGLLLKDTYCRELVSRTISLPIRGHTFPRQSRGSDASPL 1249

  Fly  1466 --EDSYS--------DSEYAAEYEQERQQNKSMATRSRLTASKTMDSFMDVSSHSNQS 1513
              ..||.        |..|........:|.......||||::::..|.:|.|..|:.|
Zfish  1250 TRRQSYDRGQPYRSPDVGYTPPPSPPLRQRNDRNVFSRLTSNQSQGSALDKSDDSDSS 1307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	147/389 (38%)
		KISc	6..359	CDD:214526	147/389 (38%)
		Kinesin_assoc	356..468	CDD:292801	16/112 (14%)
		FHA	446..546	CDD:238017	8/99 (8%)
		KIF1B	741..786	CDD:289208	15/46 (33%)
		DUF3694	<1196..1252	CDD:289256	8/55 (15%)
		CAP_GLY	1786..1850	CDD:279625
kif21b	XP_009304054.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910