Protein Alignment Khc-73 and KIF15

DIOPT Version :10

• Sequence 1: NP_001261000.1
• Gene: Khc-73 / 36718
• FlyBaseID: FBgn0019968
• Length: 1957
• Species: Drosophila melanogaster
• Sequence 2: XP_016862373.1
• Gene: KIF15 / 56992
• HGNCID: 17273
• Length: 1411
• Species: Homo sapiens
• Alignment Length: 1486
• Identity: 368/1486 - (24%)
• Similarity: 623/1486 - (41%)
• Gaps: 370/1486 - (24%)

  Fly     4 DKIKVAVRVRPFNRREIELDTK---CIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYSLNP 65
            |.|||.||:||...|....|.:   |:..:......|.:.|        :||||.|||.
Human    25 DAIKVFVRIRPPAERSGSADGEQNLCLSVLSSTSLRLHSNP--------EPKTFTFDHV------ 75

  Fly    66 EDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQES-------KGIIPRL 123
            .|.: .:||:||..|.:.|:::...|||..|||||||||||::||||..||       :|:|||.
Human    76 ADVD-TTQESVFATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSESDNFSHNLRGVIPRS 139

  Fly   124 CDQLFSAI--------ANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYV 180
            .:.|||.|        |.||     :..:.|::|||||:::||||..  ...|.:|||...|.:|
Human   140 FEYLFSLIDREKEKAGAGKS-----FLCKCSFIEIYNEQIYDLLDSA--SAGLYLREHIKKGVFV 197

  Fly   181 DGLSQLAVTSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSR 245
            .|..:..|||..:...:::.|.::|.||:|:||.|||||||||::.:..:  :::..:...:.|.
Human   198 VGAVEQVVTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVFTITIESM--EKSNEIVNIRTSL 260

  Fly   246 MSLVDLAGSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLT 310
            ::|||||||||...|.|.|.||||..|||:||:.||.||:.|.|..|||:    :.|.||||.||
Human   261 LNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVITALVDVGNGKQ----RHVCYRDSKLT 321

  Fly   311 WLLKDNLGGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVE 375
            :||:|:||||::|.::|.:.|.:..:.||||||.:|.|||.|.|.||||||.... :.:|:.||:
Human   322 FLLRDSLGGNAKTAIIANVHPGSRCFGETLSTLNFAQRAKLIKNKAVVNEDTQGN-VSQLQAEVK 385

  Fly   376 TLRSMLKH-ATGSPVGD---VQDKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQ 436
            .|:..|.. |:|....:   .:||  :..|.|    :.::|.::..::.:.|::..:||:   .|
Human   386 RLKEQLAELASGQTPPESFLTRDK--KKTNYM----EYFQEAMLFFKKSEQEKKSLIEKV---TQ 441

  Fly   437 ASGIKVEKNKYYLVNLNADPSLNELLVYYLKDRTL---------IGG-------RTISGQQPDIQ 485
            ...:.::|.|:.        ..|:::|.:.:|:.:         .||       |.:|..:.:||
Human   442 LEDLTLKKEKFI--------QSNKMIVKFREDQIIRLEKLHKESRGGFLPEEQDRLLSELRNEIQ 498

  Fly   486 LSGLGIQPEH----CVITIEDSGL--------YMEPVQGAR-CFVNGSAAVEK-----TPLQNGD 532
            .  |..|.||    ....:|:..|        .:|||:.|: ......|.:||     :.::..|
Human   499 T--LREQIEHHPRVAKYAMENHSLREENRRLRLLEPVKRAQEMDAQTIAKLEKAFSEISGMEKSD 561

  Fly   533 RILWGNHHFFRVNSPKS-NNTSMCASEPQTPAQLIDYNFARDEIMQNELSNDPIQTAIARLERQH 596
            :    |...|   |||: ....:.|:..:..|||:.        :|.||:|.         ::::
Human   562 K----NQQGF---SPKAQKEPCLFANTEKLKAQLLQ--------IQTELNNS---------KQEY 602

  Fly   597 EEDK------QVALEKQRQEYERQFQQLRNILSPSTP---------------------------- 627
            ||.|      |:.||.:.|..::....|.|:|..:..
Human   603 EEFKELTRKRQLELESELQSLQKANLNLENLLEATKACKRQEVSQLNKIHAETLKLKNVMWIYND 667

  Fly   628 --YAPYAPYDPLRMGKITPNTPTSQMRVEKWAQERDEMFRRSLGQLKTDIMRANSLVQEANFLAE 690
              ....|.:.|:::  ||..|...|:......:...||  .|.|.|.|.    ||.:.:.:.|.|
Human   668 LFNLENAGFFPIQI--ITTPTKAYQLHSRPVPKLSPEM--GSFGSLYTQ----NSSILDNDILNE 724

  Fly   691 EMEKKTKFSVTLQIPPANLSPNRRRGAFVSEPAILVKRTNSGSQI-------------WTMEKLE 742
                        .:||   ..|.:....:||....|:...|..|.             ..::|||
Human   725 ------------PVPP---EMNEQAFEAISEELRTVQEQMSALQAKLDEEEHKNLKLQQHVDKLE 774

  Fly   743 NKLIDMREMY----------QEHKERVLNGLDE--DNAKPQDPFYESQENHNLIGVANIFLEVLF 795
            :....|:|::          ||.....||.|::  ...:.::.|.:| |.|:        |.|:.
Human   775 HHSTQMQELFSSERIDWTKQQEELLSQLNVLEKQLQETQTKNDFLKS-EVHD--------LRVVL 830

  Fly   796 H-------DVKLDYHTPIISQQGEVAGRLQVEIERIAGQMPQDRM-CESVSESSGDSRDEYDDPV 852
            |       .|||:|.:...:|:.|. .:|......:..|:...|: .|.:.||....:|.||:..
Human   831 HSADKELSSVKLEYSSFKTNQEKEF-NKLSERHMHVQLQLDNLRLENEKLLESKACLQDSYDNLQ 894

  Fly   853 DPTSNQITCRVTIKCASGLPLSLSNFVFCQYTFWGHQEMVVPVINAESTAHDQNMVFKFEHTQDF 917
            :....:|         ..|..:|.||.....|.......::.::.||...::: :..:||..::
Human   895 EIMKFEI---------DQLSRNLQNFKKENETLKSDLNNLMELLEAEKERNNK-LSLQFEEDKE- 948

  Fly   918 TVTINEEFLEHCIEGALSIEVWGHRSAGFSKTKGWEVEQQQAKARSL-------------VDRWA 969
              ..::|.|: .:|..        |.....:|.  :.|||.||.:.|             :::..
Human   949 --NSSKEILK-VLEAV--------RQEKQKETA--KCEQQMAKVQKLEESLLATEKVISSLEKSR 1000

  Fly   970 ELSRKI--ELWVEIHELNDNGEYSPVEVTNRNEVLTGGIYQLR--------QGQQRRV------- 1017
            :..:|:  :|..:|.||..    |..|.|...:.|...:..:.        ..::.||
Human  1001 DSDKKVVADLMNQIQELRT----SVCEKTETIDTLKQELKDINCKYNSALVDREESRVLIKKQEV 1061

  Fly  1018 -------NVRVKPVQNSGTLPIICQSIVNVA--IGSVTVRSRLQRPLDSYQEEDLT---VLREKW 1070
                   .:|::.:.......::|:.:.:..  :..:|..|:....|....:|:||   .|.::.
Human  1062 DILDLKETLRLRILSEDIERDMLCEDLAHATEQLNMLTEASKKHSGLLQSAQEELTKKEALIQEL 1126

  Fly  1071 SEALGRRRQYLDQQIQMLIKKEEKNEQERERELSLVHQWVSLTEERNAVLVPAPGSGIPGAPASW 1135
            ...|.::::.::|      ||.|.|.:.|:.|    |...|..|:                |.|.
Human  1127 QHKLNQKKEEVEQ------KKNEYNFKMRQLE----HVMDSAAED----------------PQSP 1165

  Fly  1136 EPPSGMEPHVPVLFLNLNG--DDLSAQNT---------NDELSVAGINSILSKEHGHKFYTLQI- 1188
            :.|...:.|:..|......  :|..|..|         |::..|.....:..||...:...|::
Human  1166 KTPPHFQTHLAKLLETQEQEIEDGRASKTSLEHLVTKLNEDREVKNAEILRMKEQLREMENLRLE 1230

  Fly  1189 -LQHLDKDVCCVASW--DSSMHDSQALNRVTEANERVYLILRTTVRLSHPAPMDLVLRKRLSI-- 1248
             .|.::|      :|  ...:.|   :.|..|.:::           :||....|...:..||
Human  1231 SQQLIEK------NWLLQGQLDD---IKRQKENSDQ-----------NHPDNQQLKNEQEESIKE 1275

  Fly  1249 NIKKGQTLTDRLK-KFRLVRGENAIWQS-----GVTYEVVSNIPKASEELEDRESL 1298
            .:.|.:.:.:.|| |..|...::|::..     .:|.||.......|:..:::|.|
Human  1276 RLAKSKIVEEMLKMKADLEEVQSALYNKEMECLRMTDEVERTQTLESKAFQEKEQL 1331

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	156/372 (42%)
		Kinesin_assoc	356..468	CDD:465047	26/115 (23%)
		FHA_KIF13	446..547	CDD:438758	26/134 (19%)
		KIF1B	741..786	CDD:463574	13/56 (23%)
		DUF3694	989..1243	CDD:463599	48/295 (16%)
		CAP_GLY	1785..1850	CDD:460154
KIF15	XP_016862373.1	KISc_KLP2_like	25..373	CDD:276824	159/375 (42%)
		SMC_N	<371..643	CDD:481474	66/315 (21%)
		SMC_prok_B	<579..1362	CDD:274008	162/877 (18%)