DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc-73 and KIF15

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	XP_016862373.1	Gene:	KIF15 / 56992	HGNCID:	17273	Length:	1411	Species:	Homo sapiens

Alignment Length:	1486	Identity:	368/1486 - (24%)
Similarity:	623/1486 - (41%)	Gaps:	370/1486 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DKIKVAVRVRPFNRREIELDTK---CIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYSLNP 65
            |.|||.||:||...|....|.:   |:..:......|.:.|        :||||.|||.
Human    25 DAIKVFVRIRPPAERSGSADGEQNLCLSVLSSTSLRLHSNP--------EPKTFTFDHV------ 75

  Fly    66 EDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQES-------KGIIPRL 123
            .|.: .:||:||..|.:.|:::...|||..|||||||||||::||||..||       :|:|||.
Human    76 ADVD-TTQESVFATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSESDNFSHNLRGVIPRS 139

  Fly   124 CDQLFSAI--------ANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYV 180
            .:.|||.|        |.||     :..:.|::|||||:::||||..  ...|.:|||...|.:|
Human   140 FEYLFSLIDREKEKAGAGKS-----FLCKCSFIEIYNEQIYDLLDSA--SAGLYLREHIKKGVFV 197

  Fly   181 DGLSQLAVTSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSR 245
            .|..:..|||..:...:::.|.::|.||:|:||.|||||||||::.:..:  :::..:...:.|.
Human   198 VGAVEQVVTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVFTITIESM--EKSNEIVNIRTSL 260

  Fly   246 MSLVDLAGSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLT 310
            ::|||||||||...|.|.|.||||..|||:||:.||.||:.|.|..|||:    :.|.||||.||
Human   261 LNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVITALVDVGNGKQ----RHVCYRDSKLT 321

  Fly   311 WLLKDNLGGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVE 375
            :||:|:||||::|.::|.:.|.:..:.||||||.:|.|||.|.|.||||||.... :.:|:.||:
Human   322 FLLRDSLGGNAKTAIIANVHPGSRCFGETLSTLNFAQRAKLIKNKAVVNEDTQGN-VSQLQAEVK 385

  Fly   376 TLRSMLKH-ATGSPVGD---VQDKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQ 436
            .|:..|.. |:|....:   .:||  :..|.|    :.::|.::..::.:.|::..:||:   .|
Human   386 RLKEQLAELASGQTPPESFLTRDK--KKTNYM----EYFQEAMLFFKKSEQEKKSLIEKV---TQ 441

  Fly   437 ASGIKVEKNKYYLVNLNADPSLNELLVYYLKDRTL---------IGG-------RTISGQQPDIQ 485
            ...:.::|.|:.        ..|:::|.:.:|:.:         .||       |.:|..:.:||
Human   442 LEDLTLKKEKFI--------QSNKMIVKFREDQIIRLEKLHKESRGGFLPEEQDRLLSELRNEIQ 498

  Fly   486 LSGLGIQPEH----CVITIEDSGL--------YMEPVQGAR-CFVNGSAAVEK-----TPLQNGD 532
            .  |..|.||    ....:|:..|        .:|||:.|: ......|.:||     :.::..|
Human   499 T--LREQIEHHPRVAKYAMENHSLREENRRLRLLEPVKRAQEMDAQTIAKLEKAFSEISGMEKSD 561

  Fly   533 RILWGNHHFFRVNSPKS-NNTSMCASEPQTPAQLIDYNFARDEIMQNELSNDPIQTAIARLERQH 596
            :    |...|   |||: ....:.|:..:..|||:.        :|.||:|.         ::::
Human   562 K----NQQGF---SPKAQKEPCLFANTEKLKAQLLQ--------IQTELNNS---------KQEY 602

  Fly   597 EEDK------QVALEKQRQEYERQFQQLRNILSPSTP---------------------------- 627
            ||.|      |:.||.:.|..::....|.|:|..:..
Human   603 EEFKELTRKRQLELESELQSLQKANLNLENLLEATKACKRQEVSQLNKIHAETLKLKNVMWIYND 667

  Fly   628 --YAPYAPYDPLRMGKITPNTPTSQMRVEKWAQERDEMFRRSLGQLKTDIMRANSLVQEANFLAE 690
              ....|.:.|:::  ||..|...|:......:...||  .|.|.|.|.    ||.:.:.:.|.|
Human   668 LFNLENAGFFPIQI--ITTPTKAYQLHSRPVPKLSPEM--GSFGSLYTQ----NSSILDNDILNE 724

  Fly   691 EMEKKTKFSVTLQIPPANLSPNRRRGAFVSEPAILVKRTNSGSQI-------------WTMEKLE 742
                        .:||   ..|.:....:||....|:...|..|.             ..::|||
Human   725 ------------PVPP---EMNEQAFEAISEELRTVQEQMSALQAKLDEEEHKNLKLQQHVDKLE 774

  Fly   743 NKLIDMREMY----------QEHKERVLNGLDE--DNAKPQDPFYESQENHNLIGVANIFLEVLF 795
            :....|:|::          ||.....||.|::  ...:.::.|.:| |.|:        |.|:.
Human   775 HHSTQMQELFSSERIDWTKQQEELLSQLNVLEKQLQETQTKNDFLKS-EVHD--------LRVVL 830

  Fly   796 H-------DVKLDYHTPIISQQGEVAGRLQVEIERIAGQMPQDRM-CESVSESSGDSRDEYDDPV 852
            |       .|||:|.:...:|:.|. .:|......:..|:...|: .|.:.||....:|.||:..
Human   831 HSADKELSSVKLEYSSFKTNQEKEF-NKLSERHMHVQLQLDNLRLENEKLLESKACLQDSYDNLQ 894

  Fly   853 DPTSNQITCRVTIKCASGLPLSLSNFVFCQYTFWGHQEMVVPVINAESTAHDQNMVFKFEHTQDF 917
            :....:|         ..|..:|.||.....|.......::.::.||...::: :..:||..::
Human   895 EIMKFEI---------DQLSRNLQNFKKENETLKSDLNNLMELLEAEKERNNK-LSLQFEEDKE- 948

  Fly   918 TVTINEEFLEHCIEGALSIEVWGHRSAGFSKTKGWEVEQQQAKARSL-------------VDRWA 969
              ..::|.|: .:|..        |.....:|.  :.|||.||.:.|             :::..
Human   949 --NSSKEILK-VLEAV--------RQEKQKETA--KCEQQMAKVQKLEESLLATEKVISSLEKSR 1000

  Fly   970 ELSRKI--ELWVEIHELNDNGEYSPVEVTNRNEVLTGGIYQLR--------QGQQRRV------- 1017
            :..:|:  :|..:|.||..    |..|.|...:.|...:..:.        ..::.||
Human  1001 DSDKKVVADLMNQIQELRT----SVCEKTETIDTLKQELKDINCKYNSALVDREESRVLIKKQEV 1061

  Fly  1018 -------NVRVKPVQNSGTLPIICQSIVNVA--IGSVTVRSRLQRPLDSYQEEDLT---VLREKW 1070
                   .:|::.:.......::|:.:.:..  :..:|..|:....|....:|:||   .|.::.
Human  1062 DILDLKETLRLRILSEDIERDMLCEDLAHATEQLNMLTEASKKHSGLLQSAQEELTKKEALIQEL 1126

  Fly  1071 SEALGRRRQYLDQQIQMLIKKEEKNEQERERELSLVHQWVSLTEERNAVLVPAPGSGIPGAPASW 1135
            ...|.::::.::|      ||.|.|.:.|:.|    |...|..|:                |.|.
Human  1127 QHKLNQKKEEVEQ------KKNEYNFKMRQLE----HVMDSAAED----------------PQSP 1165

  Fly  1136 EPPSGMEPHVPVLFLNLNG--DDLSAQNT---------NDELSVAGINSILSKEHGHKFYTLQI- 1188
            :.|...:.|:..|......  :|..|..|         |::..|.....:..||...:...|::
Human  1166 KTPPHFQTHLAKLLETQEQEIEDGRASKTSLEHLVTKLNEDREVKNAEILRMKEQLREMENLRLE 1230

  Fly  1189 -LQHLDKDVCCVASW--DSSMHDSQALNRVTEANERVYLILRTTVRLSHPAPMDLVLRKRLSI-- 1248
             .|.::|      :|  ...:.|   :.|..|.:::           :||....|...:..||
Human  1231 SQQLIEK------NWLLQGQLDD---IKRQKENSDQ-----------NHPDNQQLKNEQEESIKE 1275

  Fly  1249 NIKKGQTLTDRLK-KFRLVRGENAIWQS-----GVTYEVVSNIPKASEELEDRESL 1298
            .:.|.:.:.:.|| |..|...::|::..     .:|.||.......|:..:::|.|
Human  1276 RLAKSKIVEEMLKMKADLEEVQSALYNKEMECLRMTDEVERTQTLESKAFQEKEQL 1331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	156/372 (42%)
		KISc	6..359	CDD:214526	155/370 (42%)
		Kinesin_assoc	356..468	CDD:292801	26/115 (23%)
		FHA	446..546	CDD:238017	26/133 (20%)
		KIF1B	741..786	CDD:289208	13/56 (23%)
		DUF3694	<1196..1252	CDD:289256	9/59 (15%)
		CAP_GLY	1786..1850	CDD:279625
KIF15	XP_016862373.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910