DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc-73 and kif16bb

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	XP_695424.6	Gene:	kif16bb / 567045	ZFINID:	ZDB-GENE-070424-241	Length:	1309	Species:	Danio rerio

Alignment Length:	1511	Identity:	444/1511 - (29%)
Similarity:	640/1511 - (42%)	Gaps:	364/1511 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASDKIKVAVRVRPFNRREIELDTKCIVEMEKQQT-ILQNPPPLE----KIERKQPKTFAFDHCF 60
            |||  ::|||||||.::||.:|..|.|::::.|.| :|.......    ::..::.|:|::|..:
Zfish     1 MAS--VRVAVRVRPLSQREKDLSAKVIIQVDGQITSVLSTKENFSCMNGELSGERVKSFSYDFSY 63

  Fly    61 YSLNPEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCD 125
            .|:|....||.:||.:|..:|..:|..||:|||||:||||||||||:|||||.....|:|||:|:
Zfish    64 DSMNSTSLNFVTQEKIFKDLGTDVLQAAFEGYNACVFAYGQTGSGKTYTMMGNPGDYGLIPRICE 128

  Fly   126 QLFSAIAN-KSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQ--SLKVREHNVMGPYVDGLSQLA 187
            .||..|.. ....:..:.:||||.|||||:|.||| |....|  .|:||||...|||||.||:..
Zfish   129 GLFHHIGGVLQKDKASFHMEVSYFEIYNERVRDLL-PSTETQGCELRVREHPKDGPYVDALSRHQ 192

  Fly   188 VTSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLA 252
            |.||.::..||.||||.|..|.|.||..||||||:|::...:.:.|..  :..|.||::.|||||
Zfish   193 VQSYTEVGQLMQEGNKRRATANTGMNNVSSRSHAIFTIRFIKAMFDGE--LPSETVSKVHLVDLA 255

  Fly   253 GSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQS-NGKKSGNDKFVPYRDSVLTWLLKDN 316
            |||||..|...|.|||||:|||:||.|||:|||.|||.| :|.......|||||||||||||||:
Zfish   256 GSERADATQTTGIRLKEGANINRSLVTLGIVISTLADLSVSGGIKRKQSFVPYRDSVLTWLLKDS 320

  Fly   317 LGGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSML 381
            |||||:|:|:|||||:..||.|||:|||||.|||.|:|...||||.|.:|||||:.|:..|:::|
Zfish   321 LGGNSKTIMIATISPADVNYSETLNTLRYASRAKNILNKPTVNEDSNVKIIRELQAEIARLKALL 385

  Fly   382 KHATGSPV------GDVQDKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQASGI 440
            ......|.      ..|:::|.:.|..::::::.|..:..:.:.|..|...||.|.||     |:
Zfish   386 SAGNQMPSFEQPSGSSVEERLHQDEARVQELTKQWASRWKEIQTILGEDAVALRKEGI-----GV 445

  Fly   441 KVEKNKYYLVNLNADPSLNELLVYYLKDR-TLIGGRTISGQQP--DIQLSGLGIQPEHCVITIED 502
            .::....||:.::.|.....:::|:||:. |.:|.   .|.:|  ||.|.|..:|.||||...:.
Zfish   446 VLDSQIPYLIRIDEDLLSTGVVLYHLKEGITSVGA---GGTKPEQDIVLHGEALQREHCVFENQR 507

  Fly   503 SGLYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNTSMCASEPQTPAQLID 567
            ..:.:.|:.||||.|:|....:...|..|..|..|....|..|            .||..|||.:
Zfish   508 GAVTLVPLPGARCAVSGMEVTQPYLLSQGVNIQLGKATMFHFN------------HPQEAAQLRE 560

  Fly   568 YNFARDEIMQNELSNDPIQT----AIARLERQHEEDKQVALEKQRQEYERQFQQLRNILSPSTPY 628
            ...:...:..|..:.. ::|    :..::..|||.|.. ||:......|       |:....|.:
Zfish   561 KRKSGLFVPSNSAAFS-VETFSDFSCRKVSDQHEGDAD-ALKSNTFSGE-------NLRIIPTSH 616

  Fly   629 APYAPYDPLRMGKITPNT---PTSQMRVEKWAQERDEMFRRSLGQLKTDIMRANSLVQEANFLAE 690
            ||    |.|.....|.::   |:....:.|        ..|:|    |:....|:.|.:|..|.:
Zfish   617 AP----DILLSQNKTDSSFSGPSESQHIPK--------MPRAL----TEHCATNNPVGDAKSLGK 665

  Fly   691 EMEKKTKFSVTLQIPPANLSPNRRRGAFVSEPAILVKRTNSGSQIWTMEKLENKLIDMREMYQEH 755
                      |||     .|.|.|                     |.           :::...|
Zfish   666 ----------TLQ-----TSLNIR---------------------WE-----------KQLSAPH 683

  Fly   756 KERVLNGLDEDNAKPQDPFYESQENHNLIGVANIFLEVLFHDVKLDYHTPIISQQGEVAGRLQVE 820
            |                    |:.....:.:||:.||                  ||..|
Zfish   684 K--------------------SETEAPTVDMANMKLE------------------GEETG----- 705

  Fly   821 IERIAGQMPQDRMCESVSESSGDSRDEYDDPVDPTSNQITCRVTIKCASGLPLSLSNFVFCQYTF 885
                            |.|...|||          ..|.:|..|    ||| |.:..    || .
Zfish   706 ----------------VREGLWDSR----------VLQESCNGT----SGL-LDVEQ----QY-L 734

  Fly   886 WGHQEMVVPVINAESTAHDQNMVFKFEHTQD-------FTVTINEEFLEHCIEGALSIEVWGHRS 943
            | ||     |:.:|.:...:....|..|:..       |..::..  |||..:....:.|.|..|
Zfish   735 W-HQ-----VVGSEGSLLAEESQTKRRHSATGGGEGGVFVPSLTR--LEHFSQRQSPLSVGGQFS 791

  Fly   944 AGF-SKTKGWEVEQQQAKAR-----------SLVDR--W--AELSRKIELWVEIHELNDNGEYS- 991
            ..| |:|   .||.|:|||.           |||.|  |  .:..|.:....|......:|.|:
Zfish   792 EHFLSRT---SVESQEAKAHPEGSGFSSSLGSLVGRVTWMLTDAGRVLNSLKEQTGARGSGWYNQ 853

  Fly   992 --------PVEVTNRNEVLTG--GIYQLRQGQQRRVNVRVKPVQNSGTLPIICQSIVNVAIGSVT 1046
                    |:....:.|||.|  ....|...|.||      .:.:|..|.:..|.   ||:.|:.
Zfish   854 MCSLVKDLPLVHHIQFEVLLGPQANPTLDATQFRR------NLSHSDILSVREQC---VALSSMQ 909

  Fly  1047 VRSRLQ--------RPLDSYQEEDLTVLREKWSEALGRRRQYLDQQIQMLIKKEEKNEQEREREL 1103
            ..|:..        |.|::.|.:|...::.  ||.|....|.|....:.|:..:.....:.   |
Zfish   910 DLSKSSTGKWKSPLRALEAKQTKDSVTIQS--SEGLKVCCQRLHLVPESLVHLQNLPPPQL---L 969

  Fly  1104 SLVHQWVS---LTEERNAVLVPAPGSGIPGAPASWEPPSGMEPHVPVLF----LNLNGDDL--SA 1159
            |.:|..:.   |.|||...|.     .:..|..|...|   :|.|.|:|    |.:..|.|  |:
Zfish   970 SCLHSVIPAPLLMEERVLALY-----WLSVATCSQPDP---QPAVTVIFQTKVLVITFDPLLDSS 1026

  Fly  1160 QNTND-----ELSVAGI-------------------NSILSKEHGHKFYTLQILQHLDKDVCCVA 1200
            ..|:.     |||...:                   :|||:....:...|.::.|.|.|.:|...
Zfish  1027 SPTHSLSVFYELSFQQLLEINIGFAGQSVRLTGNTESSILALHTCNAGLTQELSQTLIKAICPFE 1091

  Fly  1201 SW--DSSMHDSQALNRVTEANERVYLILRTTVRLSHPAPMDLVLRK--RLSINIKKGQTLTDRLK 1261
            .|  |..:..|..|        |:.|...:.::       ||||..  ||:.:.:|      .|.
Zfish  1092 KWTLDHPLLSSDIL--------RLSLDWSSCIK-------DLVLPSGGRLTCSFQK------TLA 1135

  Fly  1262 KFRLV-----RGE-------NAIWQSGVTYEVVSNIPKASEELEDRESLAQLAASGDD-CSASDG 1313
            |...|     :||       ..:..:.|.:...|..|...:...|.| |.||..:... |...:.
Zfish  1136 KLVFVLHGNMKGERPALADVQLLLYATVRFRQSSFEPTVPDLQVDSE-LVQLVLTDTHLCLLQEN 1199

  Fly  1314 ETYIEKYTRGVSAV--ESILTLDRLRQNVAVKEL---ETAHGQPLSM------RKTVSVPNFSQ- 1366
            ..|... .|.||.|  ::...|...||...|:.:   |...|..|.:      ||:|...|..|
Zfish  1200 AIYYPP-PRSVSVVARQAQFRLIDFRQRSEVRCVLVREGYGGMCLDVVLARANRKSVGTENHPQP 1263

  Fly  1367 --IMRFD-ASMESLLN 1379
              :...| |:.:||.|
Zfish  1264 PEVCSADKAAAQSLSN 1279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	184/363 (51%)
		KISc	6..359	CDD:214526	184/361 (51%)
		Kinesin_assoc	356..468	CDD:292801	31/117 (26%)
		FHA	446..546	CDD:238017	31/102 (30%)
		KIF1B	741..786	CDD:289208	3/44 (7%)
		DUF3694	<1196..1252	CDD:289256	13/59 (22%)
		CAP_GLY	1786..1850	CDD:279625
kif16bb	XP_695424.6	KISc_KIF1A_KIF1B	2..363	CDD:276816	186/365 (51%)
		KISc	3..363	CDD:214526	185/364 (51%)
		Kinesin_assoc	362..475	CDD:292801	32/117 (27%)
		FHA	452..551	CDD:238017	32/113 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920