Protein Alignment Khc-73 and kif1ab

DIOPT Version :10

• Sequence 1: NP_001261000.1
• Gene: Khc-73 / 36718
• FlyBaseID: FBgn0019968
• Length: 1957
• Species: Drosophila melanogaster
• Sequence 2: XP_009296795.1
• Gene: kif1ab / 566766
• ZFINID: ZDB-GENE-070912-480
• Length: 1799
• Species: Danio rerio
• Alignment Length: 1958
• Identity: 559/1958 - (28%)
• Similarity: 829/1958 - (42%)
• Gaps: 635/1958 - (32%)

  Fly     1 MASDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQP---KTFAFDHCFYS 62
            ||...:||||||||||.|||..|:|||::|....|.:.||        |||   |:|.||:.::|
Zfish     1 MAGASVKVAVRVRPFNSREIGKDSKCIIQMSGNTTTILNP--------KQPKENKSFNFDYSYWS 57

  Fly    63 -LNPEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQE--SKGIIPRLC 124
             ..|||.|:|.|:.|:..:|..:|.:||:|||.|||||||||:||||||||.||  .:||||.||
Zfish    58 HTTPEDVNYACQKQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQEGIIPLLC 122

  Fly   125 DQLFSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVT 189
            :.||:.|.:.:...:.|.|||||||||.|:|.|||:|| ||.:|:||||.:|||||:.||:||||
Zfish   123 EDLFTKINDNNDNNMSYSVEVSYMEIYCERVRDLLNPK-NKGNLRVREHPLMGPYVEDLSKLAVT 186

  Fly   190 SYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGS 254
            ||.||.:||..|||:|||||||||..||||||||:::.||...|..:..:.||||::||||||||
Zfish   187 SYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKQHDNDSENTTEKVSKISLVDLAGS 251

  Fly   255 ERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLAD-----QSNGKKSGNDKFVPYRDSVLTWLLK 314
            |||..|||.|.|||||:||||||||||.|||.||:     ..|.||...:.|:|||||||||||:
Zfish   252 ERADSTGAKGTRLKEGANINKSLTTLGKVISALAEMDSAPNKNKKKKKVESFIPYRDSVLTWLLR 316

  Fly   315 DNLGGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRS 379
            :||||||||.|||.:||:..||:|||||||||||||:|..:||:|||||.|::|||:.||..|:.
Zfish   317 ENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAVINEDPNNRLVRELKEEVARLKD 381

  Fly   380 MLKHATG-----------------------------------------------SPVGDVQ---- 393
            :| :|.|                                               |.||.:.
Zfish   382 LL-YAQGLGDIIENLSNYKANISSIQAVNQRGDFSTVTNAMTGMSPSPSLSALTSRVGSISSLHD 445

  Fly   394 ------------DKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQASGIKV---- 442
                        ::|.|:|.::.::::||||||.:||.|:.||:..|.:||::::..|..|
Zfish   446 RIMFSPGSEEAIERLKETEKIIAELNETWEEKLRRTEAIRMEREALLAEMGVAMREDGGTVGVFS 510

  Fly   443 EKNKYYLVNLNADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVIT-----IED 502
            .|...:|||||.||.::|.|:||:||.....||..:..:.||.|||..|:.|||:.|     |.:
Zfish   511 PKKTPHLVNLNEDPLMSECLLYYIKDGITKVGREDASSRQDIVLSGHFIKDEHCIFTSTTNAIGE 575

  Fly   503 SGLYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSP----KSNNTSMCASEPQTPA 563
            ..:.:||.:||..:|||....|.|.|::|:||:.|..|.||.|.|    :....:.||   .||.
Zfish   576 GTVVLEPCEGAETYVNGKRVTEPTVLKSGNRIIMGKSHVFRFNDPEQARQDRERTPCA---DTPV 637

  Fly   564 QLIDYNFARDEIMQNE--LSNDPIQTAIARLERQHEEDKQVA---LEKQRQEYERQFQQLRNILS 623
            :.:|:.||:.|:::.:  .....:...:..||.|:.::::.|   ||:||.:||.:.:.|:..::
Zfish   638 EPVDWAFAQRELLEKQGIDMKQEMDQRLQELEDQYRKEREEASNLLEQQRLDYESKLEALQKQVN 702

  Fly   624 PSTPYAPYAPYDPLRMGKITPNTPTSQMRVE---KWAQERDEM----FRR-------SLGQLKTD 674
                            .:..|.|...:..:|   .|.:...|:    ||:       ||    .|
Zfish   703 ----------------SRYYPETTEEEEELEDEVPWTKRETELALWAFRKWRFYQFTSL----RD 747

  Fly   675 IMRANSL-VQEANFLAEEMEKKTKFSVTL-------QIPPANLSP----NRRRGAFVSEPAILV- 726
            ::..|:: ::|||.::.|::||.:|...|       .:||..|.|    :|.:..|   |..:|
Zfish   748 LLWGNAIFLKEANAISVELKKKVQFQFVLLTDTLYSPLPPDLLPPSIAKDREKRLF---PRTIVA 809

  Fly   727 ----KRTNSGSQIWTMEKLENKLIDMREMYQ---------------------------------- 753
                .:.|..:..||::||..:|..|||||.
Zfish   810 VEVQDQKNGATHYWTLDKLRQRLDLMREMYDRAAEVPSTAVEDCDHIMSGGDPFYDRFPWFRLVG 874

  Fly   754 -----------------------------------------EHKERVLNGLD-----EDNAKP-- 770
                                                     |.:|..|..||     |||...
Zfish   875 RTPILNTCMSERMSGLTLSPTLSDPDSDITELADERHYGKVEVEEEELEDLDDEIFVEDNGSELG 939

  Fly   771 ---------------------QDPFYESQENHNLIGVANIFLEVLFHDVKLDYHTPIISQQGEVA 814
                                 |||||:.....:|:|.|.::|..|.:.|.|.:...|:|::|||.
Zfish   940 REEEEDDDDGVGERCPGVSDGQDPFYDRWPLFSLVGRAFVYLSNLLYPVPLVHRVAIVSEKGEVK 1004

  Fly   815 GRLQVEIERIAG--QMP------------------------QDRMCES-------------VSES 840
            |.|:|.::.|:.  :.|                        |...|.|             :.|.
Zfish  1005 GFLRVAVQAISADEEAPDYGSGVRQSGTAKISFEDQAFEKFQTEACTSGMSQTHTSEEELRIVEG 1069

  Fly   841 SGD------SRDEYDD--------------------PVDPTSNQ----------ITCRVTIKCAS 869
            .|.      |.||.::                    |:|.|.::          .|.|||:..||
Zfish  1070 EGQNSELGLSADEVNNNTCLVSPDISDSPLKGVLECPLDVTQDKSLQHLKIGSNFTFRVTVLQAS 1134

  Fly   870 GLPLSLSNFVFCQYTF-WGHQEMVVPVINAESTAHDQNM----VFKFEHTQDFTVTINEEFLEHC 929
            .:....:: :|||:.| ..|.|       |.||...:|.    ...|.|.|:.||.:.:.|:|:.
Zfish  1135 SISAEYAD-IFCQFNFIHRHDE-------AFSTEPLKNTGRGPPLGFYHVQNITVEVTKSFVEYI 1191

  Fly   930 IEGALSIEVWGHRSAGFSKTKGWEVEQQQAKARSLVDRWAELSR--------------------- 973
            ....:..||:||          ::.:......:.|:.....:.|
Zfish  1192 KSQPIVFEVFGH----------YQKQPFPPLCKDLISSLRPMRRQFPRVMPLSKPVPATKLSTLA 1246

  Fly   974 ---------KIEL--WVEIHELNDNGEYSPVEVTNRNEVLTGGIYQLRQGQQRRVNVRVKPVQNS 1027
                     |.:|  :.||.||..||:|.|..|.:|..:...|.:.|.||.|||:.|.:  ...:
Zfish  1247 RSTAGPCHCKYDLMAFFEICELEANGDYIPAVVDHRGGMPCHGTFLLHQGIQRRITVTI--AHET 1309

  Fly  1028 GTLPIICQSIVNVAIGSVTVRSRLQRPLDSYQEEDLTVLREKWSEALGRRRQYLDQQIQMLIKKE 1092
            |                                .|:     :|.|            ::.|:...
Zfish  1310 G--------------------------------NDI-----EWKE------------VKELVIGR 1325

  Fly  1093 EKNEQERERELSLVHQWVSLTEERNAVLVPAPGSGIPGAPASWEPPSGMEPHVPVLFLNLNGDDL 1157
            .:|..|.:..:                                     ::|:  :|.||:...:.
Zfish  1326 IRNTPEADETI-------------------------------------IDPN--ILSLNILSSNY 1351

  Fly  1158 SAQNTNDELSVAGINSILSKEHGHKFYTLQILQHLDKDVCCVASWDSSMHDSQALNRVTEANERV 1222
            .....:|.:|       |..:| ..||..:            |:||||||:|..|||||...|::
Zfish  1352 IRPTYDDRVS-------LGSDH-RTFYRFE------------AAWDSSMHNSLLLNRVTPYGEKI 1396

  Fly  1223 YLILRTTVRLSHPAPMDLVLRKRLSINIKKGQTLTDRLKKFRLVRGENAIWQSGVTYEVVSNIPK 1287
            |:.|...:.:.:.....:|.:....:...:..    :|...|.:|.   ::.:|....:.||...
Zfish  1397 YITLSAYLEMENCTQPTVVTKDFCMVFYSRDA----KLPASRSIRN---LFSTGAFRPLESNCVT 1454

  Fly  1288 ASEELEDRESLAQLAASGD-----------DCSASDGETYIEKYTRGVSAVESILTLDRLRQNVA 1341
            ...||    ||..||..|.           |.|.:        |.||    |..|...|.|.:..
Zfish  1455 GVYEL----SLCHLADIGSPGMQRRRRRVLDTSVA--------YVRG----EENLAGWRPRSDSL 1503

  Fly  1342 VK----ELETAHGQPLSMRKTVSVPNFSQIMRFDASMESLLNVGRSESFA-DLNNSALGNKFTPA 1401
            :.    |||     .||:.:.|.......::|  ..:|:.|.:|:...:. ||.:|       |.
Zfish  1504 ILDHQWELE-----KLSLLQEVEKTRHYLLLR--EKLEASLLLGQDSFYGKDLLDS-------PK 1554

  Fly  1402 GHSPAGAGGVIRSRHSFGGKGSSDDSPGKAFGIASPATSKLLGMRMTTLHEEPLGGHRSLDEEPE 1466
            .:||.                   .||..:.|:.||
Zfish  1555 ANSPM-------------------ISPVMSLGLDSP----------------------------- 1571

  Fly  1467 DSYSDSEYAAEYEQERQQNKSMATRS-RLTASKTMDSFMDVSSHSNQSYLSYTSSANANMKHLTG 1530
                         .|||  :.:|.:. ||........:..|||..::|.||..|::.......:.
Zfish  1572 -------------NERQ--RELAAKCVRLLMHTFNRQYSQVSSSLSESKLSEISASLLRDSVTSP 1621

  Fly  1531 LATLSMSSSTSS---GYGSQAVSCNNLSNEDIASMRSMSIDETPDFDRVNSNSPPNRQARVNPFL 1592
            |::|:.||:..|   |:.|          .|:....:.|...:||.|..   ||..|:.|...|:
Zfish  1622 LSSLTPSSTCPSLLDGHYS----------TDLRGAEANSGASSPDLDPF---SPIERKPRTCTFI 1673

  Fly  1593 KDMPKAKI 1600
            .::.:.::
Zfish  1674 PNIQEIRV 1681

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	220/365 (60%)
		Kinesin_assoc	356..468	CDD:465047	51/178 (29%)
		FHA_KIF13	446..547	CDD:438758	44/105 (42%)
		KIF1B	741..786	CDD:463574	21/147 (14%)
		DUF3694	989..1243	CDD:463599	46/253 (18%)
		CAP_GLY	1785..1850	CDD:460154
kif1ab	XP_009296795.1	KISc_KIF1A_KIF1B	4..361	CDD:276816	220/365 (60%)
		Kinesin_assoc	358..538	CDD:465047	53/180 (29%)
		FHA	514..628	CDD:469597	45/113 (40%)
		ERM_helical	647..>702	CDD:466641	12/54 (22%)
		KIF1B	828..875	CDD:463574	7/46 (15%)
		DUF3694	1273..1428	CDD:463599	46/264 (17%)
		PH_KIFIA_KIFIB	1680..1782	CDD:269939	0/2 (0%)