Protein Alignment Khc-73 and kif5aa

DIOPT Version :10

• Sequence 1: NP_001261000.1
• Gene: Khc-73 / 36718
• FlyBaseID: FBgn0019968
• Length: 1957
• Species: Drosophila melanogaster
• Sequence 2: NP_001186705.1
• Gene: kif5aa / 566086
• ZFINID: ZDB-GENE-070912-141
• Length: 1033
• Species: Danio rerio
• Alignment Length: 1388
• Identity: 317/1388 - (22%)
• Similarity: 527/1388 - (37%)
• Gaps: 452/1388 - (32%)

  Fly     2 ASDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYSLNPE 66
            |...|||..|.||.|:.||....|.:...:...|::..           .|::|||..|    |.
Zfish     6 AECNIKVLCRFRPLNQAEILRGDKFLPTFQGDDTVIIG-----------GKSYAFDRVF----PT 55

  Fly    67 DENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGT---QESKGIIPRLCDQLF 128
            :   .:||.|::...:.|:.:...|||..|||||||.|||::||.|.   .:..|||||:.:.:|
Zfish    56 N---TTQEQVYNTCAKQIVKDVLGGYNGTIFAYGQTSSGKTHTMEGNLHDPQQMGIIPRIAEDIF 117

  Fly   129 SAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQD 193
            :.|.:.. ..|.:.::|||.|||.||:.||||  ..|.:|.|.|.....|||.|.::..|:|.::
Zfish   118 NHIFSMD-ENLEFHIKVSYFEIYMEKIRDLLD--VTKTNLSVHEDKNRVPYVKGCTERFVSSPEE 179

  Fly   194 IDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQ--ILTDQATGVSGEKVSRMSLVDLAGSER 256
            :.:::.||..:|.||.||||..|||||::|.:.:.|  :.|:|      :...::.||||||||:
Zfish   180 VMDVIDEGKSNRHVAVTNMNEHSSRSHSIFLINIKQEHVETEQ------KLCGKLYLVDLAGSEK 238

  Fly   257 AVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLGGNS 321
            ..||||.|..|.|..||||||:.||.|||.||:       |....||||||.:|.:|:|:||||.
Zfish   239 VSKTGAAGAVLDEAKNINKSLSALGNVISALAE-------GTKSHVPYRDSKMTRILQDSLGGNC 296

  Fly   322 RTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSMLKHATG 386
            ||.|....|||:.|..||.|||.:..|||.|.|.|.:|
Zfish   297 RTTMFICCSPSSYNDAETKSTLMFGQRAKTIKNTASIN--------------------------- 334

  Fly   387 SPVGDVQDKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQASGIKVEKNKYYLVN 451
                            ::..::.|:.|..|            ||            ||||
Zfish   335 ----------------LELTAEQWKRKYEK------------EK------------EKNK----- 354

  Fly   452 LNADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVITIEDSGLYMEPVQGARCF 516
                         .|:|         |.|:.:::|                           |.:
Zfish   355 -------------SLRD---------SMQRLELEL---------------------------RRW 370

  Fly   517 VNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNTSMCASEPQTPAQLIDYNFARDEIMQNELS 581
            .||    ||.|                             ...||.|.::..:.:.:..:.||.|
Zfish   371 RNG----EKVP-----------------------------ETEQTDADVVKLDVSEETSLDNEKS 402

  Fly   582 NDPIQTAIARLERQHEEDKQVA------LEKQRQEYERQFQQLRNILSPSTPYAPYAPYDPLRMG 640
                    ...:|:.|.|...:      .|::||:||.:.::|...|....        |.:.:
Zfish   403 --------CERQRERERDSDTSSIVVRISEEERQKYEEEIRKLYRQLDDKD--------DEINL- 450

  Fly   641 KITPNTPTSQMRVEKWAQ---ERDEMF----------RRSLGQLKTDIMRANSLVQEANFLAEEM 692
                   ..|: |||..:   ::||:.          :..||:|:|:...|.:.|:|.....||:
Zfish   451 -------QCQL-VEKLKEQILDQDELLASTRGDSDKVQTELGRLQTESESAKAEVREVLQALEEL 507

  Fly   693 ----EKKTKFSVTLQIPPANLSPNRRRGAFVSEPAILVKRTNSGSQIWTMEKLENKLIDMREMYQ 753
                ::|::     ::...:|. |::....:|.     |..|       :.:||.:|..|:|:..
Zfish   508 AVNYDQKSQ-----EVEEKSLH-NKQLAEQLSH-----KMAN-------LMELEAELAQMQEVSS 554

  Fly   754 EHKER---VLNGLDEDNAKPQDPFYESQENHNLIGVANIFLEVLFHDVKLDYHTPIISQQGEVAG 815
            :.::|   |||||.:|          ..|..:::|...:.|.|                  |::|
Zfish   555 QQRKRIADVLNGLMKD----------LSEFSSIVGNGELKLPV------------------EISG 591

  Fly   816 RLQVE-------IERIAGQM-PQDRMCESVSESSGDSRDEYDDPVDPTSNQITCRVTIKCASGLP 872
            .::.|       |.:|..:: ...:.|..:.    :.:.|....::.||.:::.
Zfish   592 AIEEEFTVARLYISKIKSEVKSMVKRCRQLE----NMQLECHRKMEETSRELSS----------- 641

  Fly   873 LSLSNFVFCQYTFWGHQEMVVPVINAESTAHDQNMVFKFEHTQDFTVTINEEFLEHCIEGALS-- 935
                    ||.....|:..:     ...|.:.||:..|....:|....::||.  :.::.:.|
Zfish   642 --------CQLLISQHEAKI-----RSLTEYMQNVEQKKRQLEDNYDALSEEL--YTLQNSESHV 691

  Fly   936 IEVWGHRSAGFSKTKGWEVEQQQAKARSLV---DRWAELSRKIELWVEIHE---LNDNGEYSPVE 994
            .|:.|...|      ..|.:.::|..|..:   .|..:|||   |..||:|   |.|       |
Zfish   692 AELDGGEKA------DREADGKKAAVRPALHAESRQTQLSR---LRDEINEKQRLID-------E 740

  Fly   995 VTNRNEVLTGGIYQLRQGQQRRVNVRVKPVQNSGTLPIICQSIVNVAIGSVTVRSRLQRPLDSYQ 1059
            :|::|:.|...:..:|....   |::::....|..|..:                       |:|
Zfish   741 LTDKNQALELELAHVRSSFS---NLKLQDDSKSACLEQM-----------------------SFQ 779

  Fly  1060 EEDLTVLREKWSEALGRRRQYLDQQIQMLIKKEEKNEQERERELSLVH-------QWVSLTEERN 1117
            :|               |.:...|.::.|       |:...|||..:|       |.::...:::
Zfish   780 QE---------------RHEQSKQDLKGL-------EETVARELQTLHNLRKLFVQDLTTRVKKS 822

  Fly  1118 AVLVPAPGSGIPGAPASWEPPSGMEPHVPVLFLNLNGDDLSAQNTNDELSVAGINSILSKEHGHK 1182
            :.:.|....|           |..:.. .:.||..|.|.|:..:.......|.:...|.|.....
Zfish   823 SEIGPDDSGG-----------SNTQKQ-KISFLENNLDQLTKVHKQLVRDNADLRCELPKLEKRL 875

  Fly  1183 FYTLQILQHLD---KDVCCVASWDSSMHD----SQALNRVTEANERVYLILRTT-------VRLS 1233
            ..|.:.::.|:   ||     :...:|:|    .|.:.|:.:|....|.:.|..       ||..
Zfish   876 RSTAERVRALETALKD-----AKQGAMNDRRRYQQEVERIRDAMRLRYPLRRPNAAQIAKPVRPG 935

  Fly  1234 H------PAPMDLVLRKRLSINIKKGQTLTDRLKKFRLVRGENAIWQSGV-TYEVVSNIP----- 1286
            |      |....:....:.:.:....:.|.|  :|....:..|.:..|.| :.:::|:.|
Zfish   936 HHVTATSPTSFSVTRASKPATSYSNARFLQD--EKMENSQKTNTVGYSTVRSIDILSSCPLDVEN 998

  Fly  1287 KASEELEDRESLAQLAASGDDCS 1309
            ..|.::.|..|.....:..||.|
Zfish   999 GNSTDINDNRSDVHCGSMVDDAS 1021

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	145/359 (40%)
		Kinesin_assoc	356..468	CDD:465047	12/111 (11%)
		FHA_KIF13	446..547	CDD:438758	12/100 (12%)
		KIF1B	741..786	CDD:463574	13/47 (28%)
		DUF3694	989..1243	CDD:463599	46/280 (16%)
		CAP_GLY	1785..1850	CDD:460154
kif5aa	NP_001186705.1	KISc_KHC_KIF5	7..327	CDD:276820	142/353 (40%)
		SMC_prok_B	<334..614	CDD:274008	80/504 (16%)
		SMC_N	478..>809	CDD:481474	86/470 (18%)
		Khc_CBD_cc	842..911	CDD:467880	16/73 (22%)