Protein Alignment Khc-73 and kif19

DIOPT Version :10

• Sequence 1: NP_001261000.1
• Gene: Khc-73 / 36718
• FlyBaseID: FBgn0019968
• Length: 1957
• Species: Drosophila melanogaster
• Sequence 2: XP_005156460.1
• Gene: kif19 / 565913
• ZFINID: ZDB-GENE-080215-2
• Length: 1015
• Species: Danio rerio
• Alignment Length: 1318
• Identity: 302/1318 - (22%)
• Similarity: 486/1318 - (36%)
• Gaps: 434/1318 - (32%)

  Fly     5 KIKVAVRVRPFNRREIELDTKCIV-EMEKQQTIL----QNPPPLEKIERKQPKTFAFDHCF-YSL 63
            ::.||:|:||.:..|:|.....|. :::.|..:|    ::|..:.:..|.:.||:.||..| ||
Zfish    11 QLTVALRIRPLSDAELEEGATIIAHKVDDQMVVLLDPMEDPDDILRAHRSREKTYMFDVAFDYS- 74

  Fly    64 NPEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCDQLF 128
                   |:|:.|:....:|:::....||||.:||||.||.||:|||:||....||..|..:.||
Zfish    75 -------ATQDEVYRYTTKGLIEGLISGYNATVFAYGPTGCGKTYTMLGTDREPGIYVRTLNDLF 132

  Fly   129 SAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQD 193
            .|| .:::.::.|.|.:||:|||||.:.|||:  |:...|.:||.:.....|.|:::::..:.::
Zfish   133 KAI-EETSDDMQYSVSMSYLEIYNEMIRDLLN--PSSGFLDLREDSKGEIQVAGITEVSTINARE 194

  Fly   194 IDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQ------ILTDQATGVSGEKVSRMSLVDLA 252
            |..|:.:|||.||...|..|..|||||||..||:.|      ||.:       .:.:|:.::|||
Zfish   195 IMELLMKGNKQRTQEPTAANQTSSRSHAVLQVVVRQQSRCRDILQE-------VRFARLFMIDLA 252

  Fly   253 GSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNL 317
            |||||.:|...|.|||||::||:||..||..|:.|::     |:|| |:|.||||.||.||||:|
Zfish   253 GSERASQTQNRGQRLKEGAHINRSLLALGNCINALSE-----KNGN-KYVNYRDSKLTRLLKDSL 311

  Fly   318 GGNSRTVMVATISPSADNYEETLSTLRYADRAKRI---VNHAVVNEDPN----ARIIRELRHEVE 375
            ||||||||:|.|||::..:|::.:||.||||||.|   |...::|...:    ..||.:||.|::
Zfish   312 GGNSRTVMIAHISPASLAFEDSRNTLTYADRAKSIRTRVKRNLLNVSYHIAQYTSIISDLRSEIQ 376

  Fly   376 TLRSMLKHATGSPVG----DVQDKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQ 436
            .|:..:.......:.    |::...||.:....|.|:...::| :.:.|...|||
Zfish   377 RLKKKIADQASRQINPDRTDIRHVQAEVQAHSSQQSRAEMDQL-REQLIDAFRQQ---------- 430

  Fly   437 ASGIKVEKNKYYLVNLNADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVITIE 501
               :.:.|....|.|.|.:                                 :.|.....::||.
Zfish   431 ---MDIRKRLMELDNSNME---------------------------------IQIDTSKHLLTIA 459

  Fly   502 DSGLYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFR------VNSPKSNNTSMCASEPQ 560
            |                                 |....|.|      ....:|.|......:..
Zfish   460 D---------------------------------WEQERFRRRKKWQGERRKESFNKDESEKDSD 491

  Fly   561 TPAQLIDYNFARDEIMQNELSNDPIQTAIARLERQHEEDKQVALEKQRQEYERQFQQLRNILSPS 625
            :|..|.|             |.:..:.||||........:|..::||:...|::..:||.
Zfish   492 SPESLPD-------------STETQEVAIARENLVTLMAEQKKIQKQKAGLEQRLAELRE----- 538

  Fly   626 TPYAPYAPYDPLRMGKITPNTPTSQ---------MRVEKWAQERDEMFRRSLGQLKTDIMRANSL 681
                     ...|:.::.|...:|:         .:|.:...|..||  :|...||.:::|..::
Zfish   539 ---------KARRLEELLPRRVSSEEQREVLCLLCKVHELEIENAEM--QSSALLKDNVIRQKNV 592

  Fly   682 V-----QEANFLAEEMEKKTKF--SVTLQIPPANLSPNRRRGAFVSEPAILVKRTNSGSQIWTME 739
            |     |..:...|.::::.:|  ..:|.:||
Zfish   593 VVQRFEQHRHLCHEIIQQQRQFIDDHSLLVPP--------------------------------- 624

  Fly   740 KLENKLIDMREMYQEHKERVLNGLDEDNAKPQDPFYESQENHNLIGVANIFLEVL--FHDVKLDY 802
                .|.::.|||.:.       :||.|.            ..::.:....:..|  .|:..|
Zfish   625 ----HLQELYEMYMKE-------MDEKNL------------DRVVALDKFTIRTLKVHHEGSL-- 664

  Fly   803 HTPIISQQGEVAGRLQVEIERIAGQMPQDRMCESVSESSGDSRDEYDDPVDPTSNQITCRVTIKC 867
              |.|:........||        ::..|:  |||...:.|:|.
Zfish   665 --PKITLPSRGRDPLQ--------ELDSDQ--ESVRTLASDNRQ--------------------- 696

  Fly   868 ASGLPLSLSNFVFCQYTFWGHQEM---VVPVINAESTAHDQNMVFKFEHTQDFTVTI-------- 921
                               |..::   .:|.|..|.   |...|||..|.|.....:
Zfish   697 -------------------GRTKLRRHTLPPILPEP---DGERVFKSSHKQMKNTVVMTPPPIHI 739

  Fly   922 ----NEEFLEHCIEGALSIEVWGHRSAGFSKTKGWEVEQQQAKARSLVDRWAELSRKIELWVEIH 982
                |.|.|...::.||                                |.:.||..:...::..
Zfish   740 NGQGNRELLPSVLDEAL--------------------------------RCSHLSHSMSSHLDSS 772

  Fly   983 -ELNDNGEYSPVEVTNRNEVLTGGIYQLRQGQQRRVNVRVKPVQNSGTLPIICQSIVNVAIGSVT 1046
             |.::||..:|:....|.::|.|                                :.|:|:.:..
Zfish   773 PESSENGTDAPLTPKERQQILRG--------------------------------VQNIAVKAAR 805

  Fly  1047 VRSRL-----------QRPLDSYQEEDLTVLREKWSEALGRRRQYLDQQIQMLIKKEEKNEQERE 1100
            .||::           ..|||..:.:....|.|...:....||                   .|:
Zfish   806 RRSKVLEIDALRLPPPPSPLDPKKHKSNLSLSEAPPKGPVLRR-------------------GRQ 851

  Fly  1101 RELSLVHQWVSLTEERNAVLVPAPGSGIPGAPASWEPP----------------SGMEPHVPVLF 1149
            ....|.|    .|.:.|  |..:.|.| |....:|..|                .|.........
Zfish   852 PSPELRH----ATSDDN--LSSSTGDG-PAPNGTWTRPRNRQAVRNAGPREQDFEGRRRKRRSRS 909

  Fly  1150 LNLNGDDLS-AQNTNDELSVAGINSILSKEH----GHKFYTLQILQHLDKDVCCVASWDSSMHDS 1209
            ..:.|..|| |:|||...  ..::| .|..|    ||....|...||..:.....|....::|.:
Zfish   910 FEVTGQALSQAKNTNQRF--RPLDS-TSDPHLHINGHPPAPLLRPQHRAQAQLTKARPSHNIHQT 971

  Fly  1210 QALNRVTEANERVYLILR 1227
            .:...||.:|...:||.|
Zfish   972 GSTADVTSSNPPSHLIKR 989

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	149/368 (40%)
		Kinesin_assoc	356..468	CDD:465047	21/119 (18%)
		FHA_KIF13	446..547	CDD:438758	10/106 (9%)
		KIF1B	741..786	CDD:463574	7/44 (16%)
		DUF3694	989..1243	CDD:463599	50/271 (18%)
		CAP_GLY	1785..1850	CDD:460154
kif19	XP_005156460.1	KISc_KIP3_like	11..346	CDD:276821	147/358 (41%)
		EnvC	340..>558	CDD:443969	54/324 (17%)