DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc-73 and kif19

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	XP_005156460.1	Gene:	kif19 / 565913	ZFINID:	ZDB-GENE-080215-2	Length:	1015	Species:	Danio rerio

Alignment Length:	1318	Identity:	302/1318 - (22%)
Similarity:	486/1318 - (36%)	Gaps:	434/1318 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KIKVAVRVRPFNRREIELDTKCIV-EMEKQQTIL----QNPPPLEKIERKQPKTFAFDHCF-YSL 63
            ::.||:|:||.:..|:|.....|. :::.|..:|    ::|..:.:..|.:.||:.||..| ||
Zfish    11 QLTVALRIRPLSDAELEEGATIIAHKVDDQMVVLLDPMEDPDDILRAHRSREKTYMFDVAFDYS- 74

  Fly    64 NPEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCDQLF 128
                   |:|:.|:....:|:::....||||.:||||.||.||:|||:||....||..|..:.||
Zfish    75 -------ATQDEVYRYTTKGLIEGLISGYNATVFAYGPTGCGKTYTMLGTDREPGIYVRTLNDLF 132

  Fly   129 SAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQD 193
            .|| .:::.::.|.|.:||:|||||.:.|||:  |:...|.:||.:.....|.|:::::..:.::
Zfish   133 KAI-EETSDDMQYSVSMSYLEIYNEMIRDLLN--PSSGFLDLREDSKGEIQVAGITEVSTINARE 194

  Fly   194 IDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQ------ILTDQATGVSGEKVSRMSLVDLA 252
            |..|:.:|||.||...|..|..|||||||..||:.|      ||.:       .:.:|:.::|||
Zfish   195 IMELLMKGNKQRTQEPTAANQTSSRSHAVLQVVVRQQSRCRDILQE-------VRFARLFMIDLA 252

  Fly   253 GSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNL 317
            |||||.:|...|.|||||::||:||..||..|:.|::     |:|| |:|.||||.||.||||:|
Zfish   253 GSERASQTQNRGQRLKEGAHINRSLLALGNCINALSE-----KNGN-KYVNYRDSKLTRLLKDSL 311

  Fly   318 GGNSRTVMVATISPSADNYEETLSTLRYADRAKRI---VNHAVVNEDPN----ARIIRELRHEVE 375
            ||||||||:|.|||::..:|::.:||.||||||.|   |...::|...:    ..||.:||.|::
Zfish   312 GGNSRTVMIAHISPASLAFEDSRNTLTYADRAKSIRTRVKRNLLNVSYHIAQYTSIISDLRSEIQ 376

  Fly   376 TLRSMLKHATGSPVG----DVQDKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQ 436
            .|:..:.......:.    |::...||.:....|.|:...::| :.:.|...|||
Zfish   377 RLKKKIADQASRQINPDRTDIRHVQAEVQAHSSQQSRAEMDQL-REQLIDAFRQQ---------- 430

  Fly   437 ASGIKVEKNKYYLVNLNADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVITIE 501
               :.:.|....|.|.|.:                                 :.|.....::||.
Zfish   431 ---MDIRKRLMELDNSNME---------------------------------IQIDTSKHLLTIA 459

  Fly   502 DSGLYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFR------VNSPKSNNTSMCASEPQ 560
            |                                 |....|.|      ....:|.|......:..
Zfish   460 D---------------------------------WEQERFRRRKKWQGERRKESFNKDESEKDSD 491

  Fly   561 TPAQLIDYNFARDEIMQNELSNDPIQTAIARLERQHEEDKQVALEKQRQEYERQFQQLRNILSPS 625
            :|..|.|             |.:..:.||||........:|..::||:...|::..:||.
Zfish   492 SPESLPD-------------STETQEVAIARENLVTLMAEQKKIQKQKAGLEQRLAELRE----- 538

  Fly   626 TPYAPYAPYDPLRMGKITPNTPTSQ---------MRVEKWAQERDEMFRRSLGQLKTDIMRANSL 681
                     ...|:.::.|...:|:         .:|.:...|..||  :|...||.:::|..::
Zfish   539 ---------KARRLEELLPRRVSSEEQREVLCLLCKVHELEIENAEM--QSSALLKDNVIRQKNV 592

  Fly   682 V-----QEANFLAEEMEKKTKF--SVTLQIPPANLSPNRRRGAFVSEPAILVKRTNSGSQIWTME 739
            |     |..:...|.::::.:|  ..:|.:||
Zfish   593 VVQRFEQHRHLCHEIIQQQRQFIDDHSLLVPP--------------------------------- 624

  Fly   740 KLENKLIDMREMYQEHKERVLNGLDEDNAKPQDPFYESQENHNLIGVANIFLEVL--FHDVKLDY 802
                .|.::.|||.:.       :||.|.            ..::.:....:..|  .|:..|
Zfish   625 ----HLQELYEMYMKE-------MDEKNL------------DRVVALDKFTIRTLKVHHEGSL-- 664

  Fly   803 HTPIISQQGEVAGRLQVEIERIAGQMPQDRMCESVSESSGDSRDEYDDPVDPTSNQITCRVTIKC 867
              |.|:........||        ::..|:  |||...:.|:|.
Zfish   665 --PKITLPSRGRDPLQ--------ELDSDQ--ESVRTLASDNRQ--------------------- 696

  Fly   868 ASGLPLSLSNFVFCQYTFWGHQEM---VVPVINAESTAHDQNMVFKFEHTQDFTVTI-------- 921
                               |..::   .:|.|..|.   |...|||..|.|.....:
Zfish   697 -------------------GRTKLRRHTLPPILPEP---DGERVFKSSHKQMKNTVVMTPPPIHI 739

  Fly   922 ----NEEFLEHCIEGALSIEVWGHRSAGFSKTKGWEVEQQQAKARSLVDRWAELSRKIELWVEIH 982
                |.|.|...::.||                                |.:.||..:...::..
Zfish   740 NGQGNRELLPSVLDEAL--------------------------------RCSHLSHSMSSHLDSS 772

  Fly   983 -ELNDNGEYSPVEVTNRNEVLTGGIYQLRQGQQRRVNVRVKPVQNSGTLPIICQSIVNVAIGSVT 1046
             |.::||..:|:....|.::|.|                                :.|:|:.:..
Zfish   773 PESSENGTDAPLTPKERQQILRG--------------------------------VQNIAVKAAR 805

  Fly  1047 VRSRL-----------QRPLDSYQEEDLTVLREKWSEALGRRRQYLDQQIQMLIKKEEKNEQERE 1100
            .||::           ..|||..:.:....|.|...:....||                   .|:
Zfish   806 RRSKVLEIDALRLPPPPSPLDPKKHKSNLSLSEAPPKGPVLRR-------------------GRQ 851

  Fly  1101 RELSLVHQWVSLTEERNAVLVPAPGSGIPGAPASWEPP----------------SGMEPHVPVLF 1149
            ....|.|    .|.:.|  |..:.|.| |....:|..|                .|.........
Zfish   852 PSPELRH----ATSDDN--LSSSTGDG-PAPNGTWTRPRNRQAVRNAGPREQDFEGRRRKRRSRS 909

  Fly  1150 LNLNGDDLS-AQNTNDELSVAGINSILSKEH----GHKFYTLQILQHLDKDVCCVASWDSSMHDS 1209
            ..:.|..|| |:|||...  ..::| .|..|    ||....|...||..:.....|....::|.:
Zfish   910 FEVTGQALSQAKNTNQRF--RPLDS-TSDPHLHINGHPPAPLLRPQHRAQAQLTKARPSHNIHQT 971

  Fly  1210 QALNRVTEANERVYLILR 1227
            .:...||.:|...:||.|
Zfish   972 GSTADVTSSNPPSHLIKR 989

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	149/368 (40%)
		KISc	6..359	CDD:214526	149/367 (41%)
		Kinesin_assoc	356..468	CDD:292801	21/119 (18%)
		FHA	446..546	CDD:238017	10/105 (10%)
		KIF1B	741..786	CDD:289208	7/44 (16%)
		DUF3694	<1196..1252	CDD:289256	8/32 (25%)
		CAP_GLY	1786..1850	CDD:279625
kif19	XP_005156460.1	KISc	11..353	CDD:214526	149/365 (41%)
kif19	XP_005156460.1	KISc_KIP3_like	11..346	CDD:276821	147/358 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910