Protein Alignment Khc-73 and KIF16B

DIOPT Version :10

• Sequence 1: NP_001261000.1
• Gene: Khc-73 / 36718
• FlyBaseID: FBgn0019968
• Length: 1957
• Species: Drosophila melanogaster
• Sequence 2: XP_005260807.1
• Gene: KIF16B / 55614
• HGNCID: 15869
• Length: 1883
• Species: Homo sapiens
• Alignment Length: 1778
• Identity: 494/1778 - (27%)
• Similarity: 767/1778 - (43%)
• Gaps: 431/1778 - (24%)

  Fly     1 MASDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIE-------RKQPKTFAFDH 58
            |||  :||||||||.||||.:|:.|.|::|||.:|.:.|   |:..|       |::.|||.:|.
Human     1 MAS--VKVAVRVRPMNRREKDLEAKFIIQMEKSKTTITN---LKIPEGGTGDSGRERTKTFTYDF 60

  Fly    59 CFYSLNPEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRL 123
            .|||.:.:..::.|||.||..:|..::.:||:|||||:||||||||||||||||.....|:|||:
Human    61 SFYSADTKSPDYVSQEMVFKTLGTDVVKSAFEGYNACVFAYGQTGSGKSYTMMGNSGDSGLIPRI 125

  Fly   124 CDQLFSAIANKST--PELMYKVEVSYMEIYNEKVHDLLDPKPNKQ-SLKVREHNVMGPYVDGLSQ 185
            |:.|||.| |::|  .|..::.||||:|||||:|.|||..|.:|. :|:||||...||||:.||:
Human   126 CEGLFSRI-NETTRWDEASFRTEVSYLEIYNERVRDLLRRKSSKTFNLRVREHPKEGPYVEDLSK 189

  Fly   186 LAVTSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVD 250
            ..|.:|.|::.||..||.:||.|||.||..||||||:|::..||...|  :.:..|.||::.|||
Human   190 HLVQNYGDVEELMDAGNINRTTAATGMNDVSSRSHAIFTIKFTQAKFD--SEMPCETVSKIHLVD 252

  Fly   251 LAGSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQS----NGKKSGNDKFVPYRDSVLTW 311
            |||||||..|||.|.|||||.||||||.|||.|||.|||.|    |........|||||||||||
Human   253 LAGSERADATGATGVRLKEGGNINKSLVTLGNVISALADLSQDAANTLAKKKQVFVPYRDSVLTW 317

  Fly   312 LLKDNLGGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVET 376
            ||||:|||||:|:|:|||||:..||.|||||||||:|||.|:|...:|||.|.::|||||.|:..
Human   318 LLKDSLGGNSKTIMIATISPADVNYGETLSTLRYANRAKNIINKPTINEDANVKLIRELRAEIAR 382

  Fly   377 LRSMLKHATGSPVG--------DVQDKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGI 433
            |:::|  |.|:.:.        .:::||.::|..::::::.|..|..:|:.|..|:..||.|.||
Human   383 LKTLL--AQGNQIALLDSPTALSMEEKLQQNEARVQELTKEWTNKWNETQNILKEQTLALRKEGI 445

  Fly   434 SVQASGIKVEKNKYYLVNLNADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVI 498
                 |:.::....:|:.::.|.....:::|:||:.....||..:..:.||.|.||.::.|||:.
Human   446 -----GVVLDSELPHLIGIDDDLLSTGIILYHLKEGQTYVGRDDASTEQDIVLHGLDLESEHCIF 505

  Fly   499 TIEDSGLYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKS-------------- 549
            ......:.:.|:.|::|.|||...||.|.|..|..||.|..:.||.|.||.
Human   506 ENIGGTVTLIPLSGSQCSVNGVQIVEATHLNQGAVILLGRTNMFRFNHPKEAAKLREKRKSGLLS 570

  Fly   550 ----NNTSMCASEPQTPAQLIDYN---------------FARDEIMQNELSN-DPIQTAIARLER 594
                :.|.:..|.....|.:: ||               |.|.:  :.||.. :..:..|..:|.
Human   571 SFSLSMTDLSKSRENLSAVML-YNPGLFPIKGPICLRLEFERQQ--REELEKLESKRKLIEEMEE 632

  Fly   595 QHEEDK------QVALEKQRQEYE---------------RQF---QQLRNILSPSTPYAPYAPYD 635
            :.:.||      |..:|.||:|.|               |.|   .:|:::|:....:..    :
Human   633 KQKSDKAELERMQQEVETQRKETEIVQLQIRKQEESLKRRSFHIENKLKDLLAEKEKFEE----E 693

  Fly   636 PLRMGKITPNTPTSQMRVEKWAQERDEMFRRSLGQLKTDIMRANSLVQEANFLAEEMEKKTKFSV 700
            .||        ...::.::|..||.:...|     ::.::.|...|        ...||..||.:
Human   694 RLR--------EQQEIELQKKRQEEETFLR-----VQEELQRLKEL--------NNNEKAEKFQI 737

  Fly   701 TLQIPPANLSPNRRRGAFVSEPAILVKRTNSGSQIWTMEKLENKLIDMREMYQ----------EH 755
            ..::.......:.:......|...|.::..  .|:..:..||.:|.:.:||.|          |.
Human   738 FQELDQLQKEKDEQYAKLELEKKRLEEQEK--EQVMLVAHLEEQLREKQEMIQLLRRGEVQWVEE 800

  Fly   756 KERVLNGL--------------DEDN---AKPQDPFYESQENHNLIGVANIFLEVLFHDVKLDYH 803
            ::|.|.|:              |||.   .|.|..|:|. :...|:.:.|:..:::   .:.|..
Human   801 EKRDLEGIRESLLRVKEARAGGDEDGEELEKAQLRFFEF-KRRQLVKLVNLEKDLV---QQKDIL 861

  Fly   804 TPIISQQGEVAGRLQVEIERIAGQMPQDRMCESVSESSGDSRDEYDD-----PVD---------- 853
            ...:.::.|:...|:.|.::      :.|:.|...||..|..:...|     ||:
Human   862 KKEVQEEQEILECLKCEHDK------ESRLLEKHDESVTDVTEVPQDFEKIKPVEYRLQYKERQL 920

  Fly   854 --------PTSNQITCRVTIKCASGLPLSLSNFVFCQYTFWGHQEMVVPVINAESTAHDQNMVFK 910
                    ||..:...|.......| ||||.|.::........:|..:....|.:     |.:.|
Human   921 QYLLQNHLPTLLEEKQRAFEILDRG-PLSLDNTLYQVEKEMEEKEEQLAQYQANA-----NQLQK 979

  Fly   911 FEHTQDFTVTI----------NEEFLE-------HCIEGALSIEVWGHRSAGFSKTKGWEVEQQQ 958
            .:.|.:||..|          .:|.||       ..:|.||:.....|.:.....|.|.|:|:|:
Human   980 LQATFEFTANIARQEEKVRKKEKEILESREKQQREALERALARLERRHSALQRHSTLGMEIEEQR 1044

  Fly   959 AKARSLVDRWAELS-RKIELWVEIHELNDNGEYSPVEVTNRNEVLTGGIYQLRQGQQRRVNVRVK 1022
            .|..||.....|.| .:..|..|...|..:.|....|:    :.|...||:: .|.|:..:..::
Human  1045 QKLASLNSGSREQSGLQASLEAEQEALEKDQERLEYEI----QQLKQKIYEV-DGVQKDHHGTLE 1104

  Fly  1023 PVQNSGTLPIICQS-----IVNVAIGSVTVRSRLQRPL-------------------DSYQEEDL 1063
            ....|.:||:..:.     :::..|.:. :...:||.|                   |:.:..:.
Human  1105 GKVASSSLPVSAEKSHLVPLMDARINAY-IEEEVQRRLQDLHRVISEGCSTSADTMKDNEKLHNG 1168

  Fly  1064 TVLREKWSEALGRRRQ-----YLDQQI-------QMLIKKEEKN--------------------- 1095
            |:.|:...|    :||     |||..:       ..|||:|.:.
Human  1169 TIQRKLKYE----KRQFCPAWYLDPLLPRDATDTSSLIKEERREVDQNDHWDHPMLWSVSGPKTT 1229

  Fly  1096 ---EQER---ERELSLVHQWVSLTEERNAVLVPAPGSGIPGAPASWEPPSGMEPHVPVLFLN-LN 1153
               .|||   :|:.|.|.:....:|.:         .|.|.....:||.....|.:.  ||| .|
Human  1230 SSASQERTHQQRDQSSVPEVFQDSENK---------YGHPEHAGHFEPKCFNLPKIS--FLNESN 1283

  Fly  1154 GDDL-SAQNTNDELSVAGINSILSKEHGHKFYTLQILQHLDKDVCCV-ASWDSSMHDSQALNRVT 1216
            .||. ..|:.::..|                   :::.|.||....| :||....|.||.::..:
Human  1284 TDDAEDFQSQSENFS-------------------ELMTHKDKHGLRVKSSWTLLQHTSQEVSINS 1329

  Fly  1217 ---EANERVYLILRTTVRLSH------PAPMDLVLRKRLS-------INIKKGQTLTDRLKKFRL 1265
               :|.:...|.|..:..:||      .||..::..:..|       ::.|| .:.::.|...|
Human  1330 GGKQARQGKVLCLVLSEGISHEERASCSAPQSVLASEFYSEQQGEEELDAKK-MSSSESLVNIR- 1392

  Fly  1266 VRGENAIWQSGVTYEVVSNIPK--ASEELE-DRESLAQLAASGDDCSASDGETYIEKYTRGVSAV 1327
            ..|.|.:   |..|...|::.|  :|..|: ..:.::|....|:.|:.....:.:..:.|
Human  1393 TEGNNGL---GYFYHKFSDLYKDTSSHLLQAGTKVISQARLVGNLCAPRGLPSQVTTFVR----- 1449

  Fly  1328 ESILTLDRLRQNVAVKELETAHGQPLSMRKTVSVPNFSQIMRFDASMESLLNVGRSESFADLNNS 1392
             |:..|..|..::.:|         ..|:.|.|           .|.|:  .||.|||      .
Human  1450 -SLPFLKHLAPHMPLK---------TDMQSTES-----------HSPEA--RVGSSES------E 1485

  Fly  1393 ALGNKFTPAGHSPAGAGGVIRSRHSFGGKGSSDDSPGKAFGIASPATSKLLGMRMTTLHEEPLGG 1457
            |.|:.....|.:|..|.       .|...|....||...|.:
Human  1486 AAGSLRPAEGAAPYRAS-------VFAATGLPGSSPSSVFRL----------------------- 1520

  Fly  1458 HRSLDEEPEDSYSDSEYAAEYEQERQQNKSMATRSRLTASKTMDSFMDVSSHSNQSYLSYTSSA- 1521
                               |||..|   ||.|.:..|.  :..|..:.:.....:..|.:.:.:
Human  1521 -------------------EYEDAR---KSSAFKQSLV--QFPDQMLKLQECPLKDLLRHVTCSL 1561

  Fly  1522 ---NANMKHLTGLATLSMSSSTS 1541
               ..|||.:.|:..|::::.|:
Human  1562 PEPLGNMKEVKGIYWLAVAACTA 1584

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	203/368 (55%)
		Kinesin_assoc	356..468	CDD:465047	32/119 (27%)
		FHA_KIF13	446..547	CDD:438758	32/100 (32%)
		KIF1B	741..786	CDD:463574	18/71 (25%)
		DUF3694	989..1243	CDD:463599	63/328 (19%)
		CAP_GLY	1785..1850	CDD:460154
KIF16B	XP_005260807.1	KISc_KIF1A_KIF1B	2..365	CDD:276816	205/370 (55%)
		Kinesin_assoc	364..476	CDD:465047	33/118 (28%)
		FHA_KIF16B	446..562	CDD:438784	35/115 (30%)
		Smc	<606..>1089	CDD:440809	104/531 (20%)