Protein Alignment Khc-73 and KIF1A

DIOPT Version :10

• Sequence 1: NP_001261000.1
• Gene: Khc-73 / 36718
• FlyBaseID: FBgn0019968
• Length: 1957
• Species: Drosophila melanogaster
• Sequence 2: XP_047300774.1
• Gene: KIF1A / 547
• HGNCID: 888
• Length: 1825
• Species: Homo sapiens
• Alignment Length: 1991
• Identity: 576/1991 - (28%)
• Similarity: 826/1991 - (41%)
• Gaps: 658/1991 - (33%)

  Fly     1 MASDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYS-LN 64
            ||...:||||||||||.||:..|:|||::|....|.:.||    |..::.||:|:||:.::| .:
Human     1 MAGASVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNP----KQPKETPKSFSFDYSYWSHTS 61

  Fly    65 PEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQE--SKGIIPRLCDQL 127
            |||.|:|||:.|:..:|..:|.:||:|||.|||||||||:||||||||.||  .:||||:||:.|
Human    62 PEDINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLCEDL 126

  Fly   128 FSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQ 192
            ||.|.:.:...:.|.|||||||||.|:|.|||:|| ||.:|:||||.::||||:.||:||||||.
Human   127 FSRINDTTNDNMSYSVEVSYMEIYCERVRDLLNPK-NKGNLRVREHPLLGPYVEDLSKLAVTSYN 190

  Fly   193 DIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSERA 257
            ||.:||..|||:|||||||||..||||||||:::.||...|..|.::.||||::|||||||||||
Human   191 DIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKVSKISLVDLAGSERA 255

  Fly   258 VKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNG----KKSGNDKFVPYRDSVLTWLLKDNLG 318
            ..|||.|.|||||:||||||||||.|||.||:..:|    ||.....|:|||||||||||::|||
Human   256 DSTGAKGTRLKEGANINKSLTTLGKVISALAEMDSGPNKNKKKKKTDFIPYRDSVLTWLLRENLG 320

  Fly   319 GNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSMLKH 383
            |||||.|||.:||:..||:|||||||||||||:|..:||:|||||.::||||:.||..||.:| :
Human   321 GNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAVINEDPNNKLIRELKDEVTRLRDLL-Y 384

  Fly   384 ATGSPVGDVQD------------------------------------------------------ 394
            |.|  :||:.|
Human   385 AQG--LGDITDTNTVPGGPKYVSDLENNNLNRGGTVNEAPDPLSTVTNALVGMSPSSSLSALSSR 447

  Fly   395 ----------------------KLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQA 437
                                  :|.|:|.::.::::||||||.:||.|:.||:..|.:||::::.
Human   448 AASVSSLHERILFAPGSEEAIERLKETEKIIAELNETWEEKLRRTEAIRMEREALLAEMGVAMRE 512

  Fly   438 S----GIKVEKNKYYLVNLNADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVI 498
            .    |:...|...:|||||.||.::|.|:||:||.....||....::.||.|||..|:.||||.
Human   513 DGGTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGREDGERRQDIVLSGHFIKEEHCVF 577

  Fly   499 TIEDSG-----LYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSP----KSNNTSM 554
            ..:..|     :.:||.:||..:|||....|.:.|::|:||:.|..|.||.|.|    :....:.
Human   578 RSDSRGGSEAVVTLEPCEGADTYVNGKKVTEPSILRSGNRIIMGKSHVFRFNHPEQARQERERTP 642

  Fly   555 CASEPQTPAQLIDYNFARDEIMQNE--LSNDPIQTAIARLERQHEEDKQVA---LEKQRQEYERQ 614
            ||   :|||:.:|:.||:.|:::.:  .....::..:..||.|:..:::.|   ||:||.:||.:
Human   643 CA---ETPAEPVDWAFAQRELLEKQGIDMKQEMEQRLQELEDQYRREREEATYLLEQQRLDYESK 704

  Fly   615 FQQLRNILS----PSTPYAPYAPYDPLRMGKITPNTPTSQMRVEKWAQERDEM----FRR----- 666
            .:.|:..:.    |........|.|.:                 :|.:...|:    ||:
Human   705 LEALQKQMDSRYYPEVNEEEEEPEDEV-----------------QWTERECELALWAFRKWKWYQ 752

  Fly   667 --SLGQLKTDIMRANSL-VQEANFLAEEMEKKTKFSVTL-------QIPPANLSP----NRRRGA 717
              ||    .|::..|:: ::|||.::.|::||.:|...|       .:||..|.|    :|....
Human   753 FTSL----RDLLWGNAIFLKEANAISVELKKKVQFQFVLLTDTLYSPLPPDLLPPEAAKDRETRP 813

  Fly   718 FVSEPAILV-----KRTNSGSQIWTMEKLENKLIDMREMYQ----------EHKERVLNGLD--- 764
            |   |..:|     .:.|..:..||:|||..:|..|||||.          |..:.|:.|.|
Human   814 F---PRTIVAVEVQDQKNGATHYWTLEKLRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFY 875

  Fly   765 ----------------------------------------------------------------- 764
                                                                             
Human   876 DRFPWFRLVGSSAISGCNSYPLLNTCMSERMAALTPSPTFSSPDSDATEPAEEQSVGEEEEEEEE 940

  Fly   765 ---------EDNAKPQ-------DPFYESQENHNLIGVANIFLEVLFHDVKLDYHTPIISQQGEV 813
                     ||:..|:       ||||:.....:|:|.|.::|..|.:.|.|.:...|:|::|||
Human   941 EEDEEEEDLEDDVFPEHALCDGRDPFYDRPPLFSLVGRAFVYLSNLLYPVPLVHRVAIVSEKGEV 1005

  Fly   814 AGRLQVEIERIAG--QMP------------------------QDRMCESVSES-SGDSRDE---- 847
            .|.|:|.::.|:.  :.|                        |...|..|..| ||.|::|
Human  1006 KGFLRVAVQAISADEEAPDYGSGVRQSGTAKISFDDQHFEKFQSESCPVVGMSRSGTSQEELRIV 1070

  Fly   848 --------------------------------------YDDPVDPT------SNQITCRVTIKCA 868
                                                  .|.|:|..      .|..|.|||:..|
Human  1071 EGQGQGADVGPSADEVNNNTCSAVPPEGLLLDSSEKAALDGPLDAALDHLRLGNTFTFRVTVLQA 1135

  Fly   869 SGLPLSLSNFVFCQYTF-WGHQEMVVPVINAESTAHDQNM----VFKFEHTQDFTVTINEEFLEH 928
            |.:....:: :|||:.| ..|.|       |.||...:|.    ...|.|.|:..|.:.:.|:|:
Human  1136 SSISAEYAD-IFCQFNFIHRHDE-------AFSTEPLKNTGRGPPLGFYHVQNIAVEVTKSFIEY 1192

  Fly   929 CIEGALSIEVWGHRSAGFSKTKGWEVEQQQAKARSLVDRWAELSRKIE----------------- 976
            .....:..||:||...........:|......:|....|...||:.:.
Human  1193 IKSQPIVFEVFGHYQQHPFPPLCKDVLSPLRPSRRHFPRVMPLSKPVPATKLSTLTRPCPGPCHC 1257

  Fly   977 -----LWVEIHELNDNGEYSPVEVTNRNEVLTGGIYQLRQGQQRRVNVRVKPVQNSGTLPIICQS 1036
                 ::.||.||..||:|.|..|.:|..:...|.:.|.||.|||:.|
Human  1258 KYDLLVYFEICELEANGDYIPAVVDHRGGMPCMGTFLLHQGIQRRITV----------------- 1305

  Fly  1037 IVNVAIGSVTVRSRLQRPLDSYQEEDLTVLRE-----KWSEALGRRRQYLDQQIQMLIKKEEKNE 1096
                                       |:|.|     :|.|            ::.|:....:|.
Human  1306 ---------------------------TLLHETGSHIRWKE------------VRELVVGRIRNT 1331

  Fly  1097 QERERELSLVHQWVSLTEERNAVLVPAPGSGIPGAPASWEPPSGMEPHVPVLFLNLNGDDLSAQN 1161
            .|.:..|                                     ::|::    |:||
Human  1332 PETDESL-------------------------------------IDPNI----LSLN-------- 1347

  Fly  1162 TNDELSVAGINSILSKEHGHKFYTLQILQHLDKDVCCV-----ASWDSSMHDSQALNRVTEANER 1221
                        |||..:.|.  .....|.||.|:...     |:||||||:|..|||||...|:
Human  1348 ------------ILSSGYIHP--AQDDRQFLDSDIPRTFYQFEAAWDSSMHNSLLLNRVTPYREK 1398

  Fly  1222 VYLILRTTVRLSHPAPMDLVLRKRLSINIKKGQTLTDRLKKFRLVRGENAIWQSGVTYEVVSNIP 1286
            :|:.|...:.:.:.....:|.:....:...:..    :|...|.:|.   ::.||......||..
Human  1399 IYMTLSAYIEMENCTQPAVVTKDFCMVFYSRDA----KLPASRSIRN---LFGSGSLRASESNRV 1456

  Fly  1287 KASEELEDRESLAQLAASGD-----------DCSASDGETYIEKYTRGVSAVESILTLDRLRQNV 1340
            ....||    ||..:|.:|.           |.|.:        |.||    |..|...|.|.:.
Human  1457 TGVYEL----SLCHVADAGSPGMQRRRRRVLDTSVA--------YVRG----EENLAGWRPRSDS 1505

  Fly  1341 AVK----ELETAHGQPLSMRKTVSVPNFSQIMRFDASMESLLNVGRSESFADLNNSALGNKFTPA 1401
            .:.    |||     .||:.:.|.......::|     |.|....|.               .|.
Human  1506 LILDHQWELE-----KLSLLQEVEKTRHYLLLR-----EKLETAQRP---------------VPE 1545

  Fly  1402 GHSPAGAGGVIRSRHSFGGKGSSDDSPGKAFGIASPATSKLLGMRMTTLHEEPLGGHRSLDEEPE 1466
            ..|||      .|..|.....||..||..|.|..||
Human  1546 ALSPA------FSEDSESHGSSSASSPLSAEGRPSP----------------------------- 1575

  Fly  1467 DSYSDSEYAAEYEQERQQNKSMATRSRLTASKTMD---SFMDVS-SHSNQSYLSYTSSANANMKH 1527
                     .|...|||:..::.....||.:...:   |.:.|| |.|..|.:|.|...:.:|..
Human  1576 ---------LEAPNERQRELAVKCLRLLTHTFNREYTHSHVCVSASESKLSEMSVTLLRDPSMSP 1631

  Fly  1528 LTGLATLSMSSSTSS----GYGSQAVSCNNLSNEDIASMRSMSIDETPDFDRVNSNSPPNRQARV 1588
            | |:|||:.||:..|    .||:..:                   .||        .|.:|.|..
Human  1632 L-GVATLTPSSTCPSLVEGRYGATDL-------------------RTP--------QPCSRPASP 1668

  Fly  1589 NPFLKDMPKAKIQEQPEQQAKKLQEAFTHPLEQLESSQNAQ 1629
            .|.|          .||..:|||..    |....|:.:..|
Human  1669 EPEL----------LPEADSKKLPS----PARATETDKEPQ 1695

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	220/361 (61%)
		Kinesin_assoc	356..468	CDD:465047	51/191 (27%)
		FHA_KIF13	446..547	CDD:438758	43/105 (41%)
		KIF1B	741..786	CDD:463574	19/138 (14%)
		DUF3694	989..1243	CDD:463599	50/263 (19%)
		CAP_GLY	1785..1850	CDD:460154
KIF1A	XP_047300774.1	KISc_KIF1A_KIF1B	4..361	CDD:276816	220/361 (61%)
		Kinesin_assoc	358..549	CDD:465047	53/193 (27%)
		FHA_KIF1A	525..639	CDD:438778	44/113 (39%)
		ERM_helical	658..>711	CDD:466641	12/52 (23%)
		KIF1B	839..886	CDD:463574	11/46 (24%)
		DUF3694	1275..1431	CDD:463599	50/274 (18%)
		PH_KIFIA_KIFIB	1706..1808	CDD:269939