Protein Alignment Khc-73 and LOC4576148

DIOPT Version :10

• Sequence 1: NP_001261000.1
• Gene: Khc-73 / 36718
• FlyBaseID: FBgn0019968
• Length: 1957
• Species: Drosophila melanogaster
• Sequence 2: XP_061512564.1
• Gene: LOC4576148 / 4576148
• VectorBaseID: AGAMI1_001728
• Length: 1254
• Species: Anopheles gambiae
• Alignment Length: 1233
• Identity: 301/1233 - (24%)
• Similarity: 501/1233 - (40%)
• Gaps: 293/1233 - (23%)

  Fly     6 IKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYSLNPEDENF 70
            :|||||:||.::.|.....:.:||    |.....|..|....|.....|::.:.|    |..
Mosquito    32 VKVAVRIRPMSQSEQARGCQTVVE----QAAPGAPQLLVCGGRTPSDVFSYSYVF----PPS--- 85

  Fly    71 ASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGT------QESKGIIPRLCDQLFS 129
            ..|..:::.....:|...|.||||.|.|||||.|||::| |||      ..|.|:|||..:.:|.
Mosquito    86 TVQSQLYEVAVSPMLHKLFAGYNATILAYGQTSSGKTFT-MGTHFAGEVDSSVGVIPRAINDIFR 149

  Fly   130 AIAN---KSTPELMYKVEVSYMEIYNEKVHDLLDPKP---NKQSLKVREHNVMGPYV-DGLSQLA 187
            .:|:   :.|..:..:|..||:|:|.::|.|||..||   .:|.:.:|| .|.|..: .||:::|
Mosquito   150 LMADGTAEVTAHVDTRVTCSYIEVYQDQVFDLLAEKPAGTERQPVDIRE-AVGGDIILQGLTEVA 213

  Fly   188 VTSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLA 252
            ....|...:.:..|:..|.|.||.||..||||||:|::.|.....|....|:.   |:..|||||
Mosquito   214 AGGVQSAFDCLARGSLGRVVRATAMNNVSSRSHAIFTLTLHHTARDDPAVVTR---SKFHLVDLA 275

  Fly   253 GSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNL 317
            ||||:.||...|||.|||..|||.|..||.||:.|...:.   :.....:|||.|.||.||:|:|
Mosquito   276 GSERSKKTDTTGDRFKEGVQINKCLLALGNVITALGSSAG---AAGKMHIPYRSSKLTRLLQDSL 337

  Fly   318 GGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLR---S 379
            ||||.|:|:|.:||:..|..||.||||||:|..:|.|..:||:||....|::|...|:.||   .
Mosquito   338 GGNSYTLMIACVSPADYNLSETYSTLRYANRVCKIKNKPIVNQDPQQARIKQLEAIVQDLRVEVM 402

  Fly   380 MLKHA-TGSPVGDVQDKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQASGIK-- 441
            |||.. .|.|....:|   .:..:.:.:.......|.:|:.:::.|..  |....|..::|.:
Mosquito   403 MLKSGREGCPPTTDKD---GTFRVPQPVHSPLVRGLTETQLLRSPRSS--EAGSASDPSAGYQKL 462

  Fly   442 VEKNKYYLVNLNADPSLNELLVYYLKDRTLIGGRTISGQQPDI-QLSGLGIQPEHCVITIEDSGL 505
            .|.|:.....|.|  :::||.|:  ::|:::..:.:.    || ||.|...||       .:.||
Mosquito   463 QEANRCLQKQLQA--TMHELEVH--EERSMLAEKLLE----DIEQLLGREAQP-------GEDGL 512

  Fly   506 YME-----PVQGARCFVNGS-AAVEKTPLQNGDRILWGNHHFFRVNSPKSNNTSMCASEPQTPAQ 564
            ..|     .......:..|| :|....||   .|::..:.....|:.|.........||..|..|
Mosquito   513 RQELARLLTAHQDEVYSLGSLSAAYGPPL---SRMIRPSTAGAGVDDPLRTEEFERKSEFHTQQQ 574

  Fly   565 LIDYN----FARDEIMQNEL------SNDPIQTAIARLERQHEEDKQVALEKQRQEYERQFQQLR 619
            :..::    ..|:..::.||      ::..:|:..:|.||:        |.:|..|||.|.:.|.
Mosquito   575 IRIHSELTQLKREIALKEELHRKCQGNSAAVQSYTSRRERE--------LTEQLHEYEGQMRSLE 631

  Fly   620 NILSPSTPYAPYAPYDPLRMGKITPNTPTSQMRVEKWAQERDEMFRRSLGQLKTDIMRANSLVQE 684
            ..|:              .:..:..||..|:.| .|.|:||    ||.:.||:.:
Mosquito   632 GQLA--------------ELNALLENTKASEKR-SKLAEER----RRKVQQLEAE---------- 667

  Fly   685 ANFLAEEMEKKTKFSVTLQIPPANLSPNRRRGAFVSEPAILVKRTNSGSQIWTMEKLENKLIDMR 749
               |||..:|..:.:..|::.    ..:..|.|.:|.....:|.|    ::..::.|..:....|
Mosquito   668 ---LAEMRQKSARQAKLLKLH----EKDAERIAGLSSEIQQMKAT----RVKLLKTLRTESESFR 721

  Fly   750 EMYQEHKERVLNGLDEDNAKPQDPFYESQENHNLIGVANIFLEVLFHDVKLDYHTPIISQQGEVA 814
            : ::..:|:.:..|...:.|.|   |:.|:..:...:....::     .|:|       :..:|.
Mosquito   722 Q-WRASREKEITQLKAKDRKQQ---YQLQKLESTYSMQKRIMQ-----RKMD-------ETIQVN 770

  Fly   815 GRLQVEIERIAGQMPQDRMCESVSESSGDSRDEYDDPVDPTSNQITCRVTIKCASGLPLSLSNFV 879
            .||:..:||      |.|     |:::..:||               |..::.|
Mosquito   771 KRLKATLER------QQR-----SKTAAGARD---------------RAAMRGA----------- 798

  Fly   880 FCQYTFWGHQEMVVPVINAESTAHDQNMVFKFEHTQDFTVTINEEFLEHCIEGALSIEVWGHRSA 944
              :...|..||:                                |.:.:.:|..:::.|...:.|
Mosquito   799 --EAARWVKQEL--------------------------------ELICNTVEATVTLSVLRAQRA 829

  Fly   945 GFSKTKGWEVEQQQAKARSLVDRWAELSRK------------------IELWVEIHELNDNGEYS 991
            ...|    :::|.:.:...|.:..||..|.                  ::|..::|.::.:.:.:
Mosquito   830 QEVK----KIKQMEGQCAELPEGGAEYQRLRQDIQQCQLDLDYRNAQIVDLQTKLHTIDTDSQVA 890

  Fly   992 P-----VEVTNRNEVLTGGIYQLRQGQQRRVNVRVKPVQNSGTLPIICQSIVNVAIGSVTVRSRL 1051
            .     .::....:.....:.||.|...|.:..|.:.|....|
Mosquito   891 AFGEGLAKLPEARDAFQQLLEQLVQTHTRLIETRFQLVDLQAT---------------------- 933

  Fly  1052 QRPLDSYQEEDLTVLREKWSEALGRRRQYLDQQIQMLIKKEEKNEQERERELSLVHQWVSLTEER 1116
                ...|||:|..:|.:...|   .:||.::.:|:        |:..|.:|:|      |..:|
Mosquito   934 ----GDCQEEELAQVRAQLEAA---DQQYREEVVQL--------EKRYEDKLAL------LLMQR 977

  Fly  1117 N-----AVLVPAPGSGIPGAPASWEPPSGMEPHVPVLFLNLNGDDL-----SAQNTNDELSVA 1169
            .     |...|..|:|..|.....|..:|......:..:....|:|     |||...::|..|
Mosquito   978 TGGAAAATAAPTNGTGAEGEEVEEEAGTGAVHEEAIRRIEQLRDELELYKRSAQMLREQLDEA 1040

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	140/365 (38%)
		Kinesin_assoc	356..468	CDD:465047	28/117 (24%)
		FHA_KIF13	446..547	CDD:438758	23/107 (21%)
		KIF1B	741..786	CDD:463574	8/44 (18%)
		DUF3694	989..1243	CDD:463599	36/196 (18%)
		CAP_GLY	1785..1850	CDD:460154
LOC4576148	XP_061512564.1	None