Protein Alignment Khc-73 and kif18a

DIOPT Version :10

• Sequence 1: NP_001261000.1
• Gene: Khc-73 / 36718
• FlyBaseID: FBgn0019968
• Length: 1957
• Species: Drosophila melanogaster
• Sequence 2: NP_956533.1
• Gene: kif18a / 393209
• ZFINID: ZDB-GENE-040426-862
• Length: 895
• Species: Danio rerio
• Alignment Length: 660
• Identity: 204/660 - (30%)
• Similarity: 312/660 - (47%)
• Gaps: 139/660 - (21%)

  Fly     6 IKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLE------------KIERKQPK--TFAF 56
            :||.|||||.|.:|.:.:.|.:|.:.....::.:|...|            .:.::..|  .|.|
Zfish    10 VKVVVRVRPLNDKEKDGNFKKVVHVVDNHMLVFDPKEEEVTFFRGQRVGNRDVRKRANKDLKFVF 74

  Fly    57 DHCFYSLNPEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIP 121
            |..|     .:|  :||..||:...:.|:|....|||..:||||.||:||::||:||..|.|::.
Zfish    75 DSVF-----GEE--SSQIEVFENTTKAIVDGVLNGYNCTVFAYGATGAGKTHTMLGTSNSPGVMF 132

  Fly   122 RLCDQLFSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQL 186
            ....:||:.: :....:.::.|..||:|:|||::.|||   .|...|.|||....|..|.||:..
Zfish   133 LTMKELFARM-DLIKEDKVFNVAFSYLEVYNEQIRDLL---TNSGPLAVREDGSNGVVVQGLTLH 193

  Fly   187 AVTSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVS-GEKVSRMSLVD 250
            ...|.:.|...:..||::||...|:|||.||||||||.:.|.|  .|:...:: ..:|::|||:|
Zfish   194 QPKSAEHILEALDYGNRNRTQHPTDMNATSSRSHAVFQIYLRQ--QDKTASLNPNVRVAKMSLID 256

  Fly   251 LAGSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKD 315
            |||||||..|...|.||:||:|||:||..||.||:.||:....|     ..:|||||.||.||||
Zfish   257 LAGSERASATNTKGARLREGANINRSLLALGNVINTLANPKCKK-----THIPYRDSKLTRLLKD 316

  Fly   316 NLGGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSM 380
            :||||.||||:|.:|||:.:||:|.:||:||:|||.|.:                     ||||.
Zfish   317 SLGGNCRTVMIANVSPSSLSYEDTHNTLKYANRAKEIKS---------------------TLRSN 360

  Fly   381 LKHATGSPVGD---VQDKLAESENLMKQISQTWEEKLVKTER-----IQNERQQALEKMGISVQ- 436
            :. :..|.:|.   :.:|......::||..:.:||:  |.|.     |..:::...|||..|::
Zfish   361 VM-SLDSHIGQYAIICEKQKAEIVMLKQKLKEYEER--KAEAPALNPISIQKRAEFEKMSESLRS 422

  Fly   437 --ASGIKVEKNKYYLVNLNADPSLNELLVYYLKDRTLIGGRTISGQQ-----PD----------- 483
              :..:|:.|.     :|:.:..|||       .|..:..|....||     ||
Zfish   423 VFSDRLKLRKE-----HLDIEKQLNE-------SRLTMRHRESWHQQSLIFFPDNKAERATCKYE 475

  Fly   484 IQLSGLGIQPEHCVITIEDSGLYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPK 548
            .:|:.|....||         |....::..:||......:.:  ::|..::|..:.|
Zfish   476 RKLASLKSHQEH---------LQQRLMESEKCFQENEGWLHR--IENEMKLLGHDGH-------- 521

  Fly   549 SNNTSMCASEPQTPAQLIDYNFARDEIMQNELSNDPIQTAIARLERQHEEDKQVALEKQRQEYER 613
                        ||.:|           :.||....:|..|:.|: ||.|.....:..|.||...
Zfish   522 ------------TPEEL-----------KKELQCHQLQLQISDLQ-QHMEHMSHLISVQDQENTH 562

  Fly   614 QFQQLRNILS 623
            ..:.:..:||
Zfish   563 THKLVNALLS 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	148/367 (40%)
		Kinesin_assoc	356..468	CDD:465047	24/122 (20%)
		FHA_KIF13	446..547	CDD:438758	20/116 (17%)
		KIF1B	741..786	CDD:463574
		DUF3694	989..1243	CDD:463599
		CAP_GLY	1785..1850	CDD:460154
kif18a	NP_956533.1	KISc_KIP3_like	9..353	CDD:276821	147/360 (41%)
		SMC_N	<345..572	CDD:481474	60/305 (20%)