Protein Alignment Khc-73 and KIFC3

DIOPT Version :10

• Sequence 1: NP_001261000.1
• Gene: Khc-73 / 36718
• FlyBaseID: FBgn0019968
• Length: 1957
• Species: Drosophila melanogaster
• Sequence 2: XP_006721251.1
• Gene: KIFC3 / 3801
• HGNCID: 6326
• Length: 1022
• Species: Homo sapiens
• Alignment Length: 430
• Identity: 150/430 - (34%)
• Similarity: 223/430 - (51%)
• Gaps: 77/430 - (17%)

  Fly    17 RREIELDTKC---IVEMEKQQTILQNPPPLEKIERKQPK-----TFAFD-----HCFYSLNPE-- 66
            |||::|..||   :|.::....::....|:.|.:.:.|:     ||..|     |..:...|.
Human   615 RRELQLRKKCHNELVRLKGNIRVIARVRPVTKEDGEGPEATNAVTFDADDDSIIHLLHKGKPVSF 679

  Fly    67 --DENF---ASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCDQ 126
              |:.|   |||:.||..| :.::.:...|:|.|||||||||:||:|||.||.|:.||..|....
Human   680 ELDKVFSPQASQQDVFQEV-QALVTSCIDGFNVCIFAYGQTGAGKTYTMEGTAENPGINQRALQL 743

  Fly   127 LFSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGP------YVDGLSQ 185
            |||.:..|:: :..|.:.||..|||||.:.|||..:| ::.|::|    :.|      ||.||::
Human   744 LFSEVQEKAS-DWEYTITVSAAEIYNEVLRDLLGKEP-QEKLEIR----LCPDGSGQLYVPGLTE 802

  Fly   186 LAVTSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVD 250
            ..|.|..||:.:...|:.:||...||:|..||||||:..|.:..:  |.:||:  ....:::|||
Human   803 FQVQSVDDINKVFEFGHTNRTTEFTNLNEHSSRSHALLIVTVRGV--DCSTGL--RTTGKLNLVD 863

  Fly   251 LAGSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKD 315
            ||||||..|:||.|.||:|..:|||||:.||.||:.|..:..        .||:|:|.||:||:|
Human   864 LAGSERVGKSGAEGSRLREAQHINKSLSALGDVIAALRSRQG--------HVPFRNSKLTYLLQD 920

  Fly   316 NLGGNSRTVMVATISPSADNYEETLSTLRYADRAKRI----------------VNH-----AVVN 359
            :|.|:|:|:||..:||...|..|||.:|::|:|.:.:                ..|     |...
Human   921 SLSGDSKTLMVVQVSPVEKNTSETLYSLKFAERVRSVELGPGLRRAELGSWSSQEHLEWEPACQT 985

  Fly   360 EDPNARIIRELRHEVETLRSMLKHATGSPVGDVQDKLAES 399
            ..|:||           ..|.....|.|..|.::.||..|
Human   986 PQPSAR-----------AHSAPSSGTSSRPGSIRRKLQPS 1014

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	140/388 (36%)
		Kinesin_assoc	356..468	CDD:465047	11/44 (25%)
		FHA_KIF13	446..547	CDD:438758
		KIF1B	741..786	CDD:463574
		DUF3694	989..1243	CDD:463599
		CAP_GLY	1785..1850	CDD:460154
KIFC3	XP_006721251.1	SMC_prok_B	294..>618	CDD:274008	2/2 (100%)
		KISc_C_terminal	632..959	CDD:276817	131/345 (38%)