Protein Alignment Khc-73 and KIF5C

DIOPT Version :10

• Sequence 1: NP_001261000.1
• Gene: Khc-73 / 36718
• FlyBaseID: FBgn0019968
• Length: 1957
• Species: Drosophila melanogaster
• Sequence 2: NP_004513.1
• Gene: KIF5C / 3800
• HGNCID: 6325
• Length: 957
• Species: Homo sapiens
• Alignment Length: 1019
• Identity: 260/1019 - (25%)
• Similarity: 411/1019 - (40%)
• Gaps: 288/1019 - (28%)

  Fly     2 ASDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYSLNPE 66
            |...|||..|.||.|..||....|.|.:.:..:|::..          |.|.:.||..   |.|.
Human     5 AECSIKVMCRFRPLNEAEILRGDKFIPKFKGDETVVIG----------QGKPYVFDRV---LPPN 56

  Fly    67 DENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMG---TQESKGIIPRLCDQLF 128
                .:||.|::...:.|:.:..:|||..|||||||.|||::||.|   ..:..|||||:...:|
Human    57 ----TTQEQVYNACAKQIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIAHDIF 117

  Fly   129 SAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQD 193
            ..|.:.. ..|.:.::|||.|||.:|:.||||  .:|.:|.|.|.....|||.|.::..|:|.::
Human   118 DHIYSMD-ENLEFHIKVSYFEIYLDKIRDLLD--VSKTNLAVHEDKNRVPYVKGCTERFVSSPEE 179

  Fly   194 IDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSERAV 258
            :.:::.||..:|.||.||||..|||||::|.:.:.|...:....:||    ::.||||||||:..
Human   180 VMDVIDEGKANRHVAVTNMNEHSSRSHSIFLINIKQENVETEKKLSG----KLYLVDLAGSEKVS 240

  Fly   259 KTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLGGNSRT 323
            ||||.|..|.|..||||||:.||.|||.||:       |....||||||.:|.:|:|:||||.||
Human   241 KTGAEGAVLDEAKNINKSLSALGNVISALAE-------GTKTHVPYRDSKMTRILQDSLGGNCRT 298

  Fly   324 VMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVE-----TLRSMLKH 383
            .:|...|||..|..||.|||.:..|||.|.|...||.:..|...:: ::|.|     ||:::::|
Human   299 TIVICCSPSVFNEAETKSTLMFGQRAKTIKNTVSVNLELTAEEWKK-KYEKEKEKNKTLKNVIQH 362

  Fly   384 ------------------------------ATGSPV----------------------------- 389
                                          ...:|:
Human   363 LEMELNRWRNGEAVPEDEQISAKDQKNLEPCDNTPIIDNIAPVVAGISTEEKEKYDEEISSLYRQ 427

  Fly   390 -GDVQDKLAESENLMKQISQTW---EEKLVKTER-------------IQNERQ--------QALE 429
             .|..|::.:...|.:::.|..   :|.|..|.|             |:||..        ||||
Human   428 LDDKDDEINQQSQLAEKLKQQMLDQDELLASTRRDYEKIQEELTRLQIENEAAKDEVKEVLQALE 492

  Fly   430 KMGISVQASGIKVEKNKYYLVNLNADPSLNELLVYYLKDRTLIGGRTISGQQPDI-QLSGL---- 489
            ::.::......:||..          ...||.|...|..:|    .|::..|.:: ||..|
Human   493 ELAVNYDQKSQEVEDK----------TRANEQLTDELAQKT----TTLTTTQRELSQLQELSNHQ 543

  Fly   490 -------------------GIQPEHCVITIED-SGLYMEPVQGARCFVNGSAAVEKTPLQNGDRI 534
                               ||...:.|.|:.| :|:..|....||.:::...:..|:.:....::
Human   544 KKRATEILNLLLKDLGEIGGIIGTNDVKTLADVNGVIEEEFTMARLYISKMKSEVKSLVNRSKQL 608

  Fly   535 LWGNHHFFRVNSPKSNNTSMCASEPQTPA--QLIDYNFAR----DEIMQN--------ELSNDPI 585
                     .::...:|..|.|||.:..|  .||..:.|:    .:.|||        |.|.|.:
Human   609 ---------ESAQMDSNRKMNASERELAACQLLISQHEAKIKSLTDYMQNMEQKRRQLEESQDSL 664

  Fly   586 QTAIARLERQHEEDKQVALEKQRQEYERQFQQLRNILSPSTPYAPYAPYDPLRMGKITPNTPTSQ 650
            ...:|:| |..|:..:|:.:.:.:|:..:.|                  |...|.|
Human   665 SEELAKL-RAQEKMHEVSFQDKEKEHLTRLQ------------------DAEEMKK--------- 701

  Fly   651 MRVEKWAQERDEMFRRSLGQLKTDIMRANSLVQEANFLAEEMEKKTKFSVTLQIPPANLSPNRRR 715
             .:|:..:...|..::.|.:|:.:|.....::.|...|.::          ||:....||.:..:
Human   702 -ALEQQMESHREAHQKQLSRLRDEIEEKQKIIDEIRDLNQK----------LQLEQEKLSSDYNK 755

  Fly   716 GAFVSEPAILVKRTNSGSQIWTMEKLENKLI--DMREMYQEHKERVLNGLDEDNAKPQDPFYESQ 778
                      :|..:...::    |||..|:  |.||..:|.    |.||:|..::      |.|
Human   756 ----------LKIEDQEREM----KLEKLLLLNDKREQARED----LKGLEETVSR------ELQ 796

  Fly   779 ENHNLIGVANIFLEVLFHDVKLDYHTPIISQQGEVAGRLQV--------EIERIAGQMPQDR--- 832
            ..|||   ..:|::.|...||...........|..|.:.::        ::.::..|:.:|.
Human   797 TLHNL---RKLFVQDLTTRVKKSVELDNDDGGGSAAQKQKISFLENNLEQLTKVHKQLVRDNADL 858

  Fly   833 MCE-----------------------SVSESSGDSRDEYDDPVD 853
            .||                       ...|::...|..|...||
Human   859 RCELPKLEKRLRATAERVKALESALKEAKENAMRDRKRYQQEVD 902

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	144/357 (40%)
		Kinesin_assoc	356..468	CDD:465047	30/200 (15%)
		FHA_KIF13	446..547	CDD:438758	20/125 (16%)
		KIF1B	741..786	CDD:463574	16/46 (35%)
		DUF3694	989..1243	CDD:463599
		CAP_GLY	1785..1850	CDD:460154
KIF5C	NP_004513.1	KISc_KHC_KIF5	6..327	CDD:276820	142/351 (40%)
		Microtubule-binding	174..315		70/151 (46%)
		PRK03918	<412..907	CDD:235175	106/580 (18%)
		Khc_CBD_cc	836..905	CDD:467880	9/67 (13%)
		Globular	859..956		7/44 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	911..957