DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Khc-73 and KIF5B

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	NP_004512.1	Gene:	KIF5B / 3799	HGNCID:	6324	Length:	963	Species:	Homo sapiens

Alignment Length:	1029	Identity:	269/1029 - (26%)
Similarity:	407/1029 - (39%)	Gaps:	308/1029 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYSLNP 65
            :|...|||..|.||.|..|:....|.|.:.:.:.|::....|           :|||..|
Human     4 LAECNIKVMCRFRPLNESEVNRGDKYIAKFQGEDTVVIASKP-----------YAFDRVF----- 52

  Fly    66 EDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMG---TQESKGIIPRLCDQL 127
              ::..|||.|::...:.|:.:..:|||..|||||||.|||::||.|   ..|..|||||:...:
Human    53 --QSSTSQEQVYNDCAKKIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPEGMGIIPRIVQDI 115

  Fly   128 FSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQ 192
            |:.|.:.. ..|.:.::|||.|||.:|:.||||  .:|.:|.|.|.....|||.|.::..|.|..
Human   116 FNYIYSMD-ENLEFHIKVSYFEIYLDKIRDLLD--VSKTNLSVHEDKNRVPYVKGCTERFVCSPD 177

  Fly   193 DIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSERA 257
            ::.:.:.||..:|.||.||||..|||||::|.:.:.|..|.....:||    ::.||||||||:.
Human   178 EVMDTIDEGKSNRHVAVTNMNEHSSRSHSIFLINVKQENTQTEQKLSG----KLYLVDLAGSEKV 238

  Fly   258 VKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLGGNSR 322
            .||||.|..|.|..||||||:.||.|||.||:.|.        :||||||.:|.:|:|:||||.|
Human   239 SKTGAEGAVLDEAKNINKSLSALGNVISALAEGST--------YVPYRDSKMTRILQDSLGGNCR 295

  Fly   323 TVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRE-----------LRHEVET 376
            |.:|...|||:.|..||.|||.:..|||.|.|...||.:..|...::           ||:.::.
Human   296 TTIVICCSPSSYNESETKSTLLFGQRAKTIKNTVCVNVELTAEQWKKKYEKEKEKNKILRNTIQW 360

  Fly   377 LRSML------------------------------------KHATGSPV----GDVQDKLAESE- 400
            |.:.|                                    |.||...|    .|.:.:..|.|
Human   361 LENELNRWRNGETVPIDEQFDKEKANLEAFTVDKDITLTNDKPATAIGVIGNFTDAERRKCEEEI 425

  Fly   401 -NLMKQISQ--------------------TWEEKLVKTERIQNERQ------------------- 425
             .|.||:..                    ..||.|..|.|.|:..|
Human   426 AKLYKQLDDKDEEINQQSQLVEKLKTQMLDQEELLASTRRDQDNMQAELNRLQAENDASKEEVKE 490

  Fly   426 --QALEKMGISVQASGIKVE-KNKYY-------------LVNLNAD------------PSLNELL 462
              ||||::.::......:|| |.|.|             |.:::|:            ....|::
Human   491 VLQALEELAVNYDQKSQEVEDKTKEYELLSDELNQKSATLASIDAELQKLKEMTNHQKKRAAEMM 555

  Fly   463 VYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVITIEDSGLYMEPVQGARCFVNGSAAVEKTP 527
            ...|||...||   |:....|::      ||       |.:|:..|....||.:::...:..||.
Human   556 ASLLKDLAEIG---IAVGNNDVK------QP-------EGTGMIDEEFTVARLYISKMKSEVKTM 604

  Fly   528 LQNGDRILWGNHHFFRVNSPKSNNTSMCASEPQTPAQLIDYNFARDEIMQNELSNDPIQTAIARL 592
            ::             |....:|..|.                 :..::.:||......|..|:
Human   605 VK-------------RCKQLESTQTE-----------------SNKKMEENEKELAACQLRIS-- 637

  Fly   593 ERQHEEDKQVALEKQRQEYERQFQQLRNILSPSTPYAPYAPYDPLRMGKITPNTPTSQMRVEKWA 657
              |||     |..|...||.:..:|.:..|..|.        |.|           |:..|:..|
Human   638 --QHE-----AKIKSLTEYLQNVEQKKRQLEESV--------DAL-----------SEELVQLRA 676

  Fly   658 QER-DEMFRRSLGQLKTDIMRANSLVQ---------------EANFLAEEMEKKTKFSVTLQIPP 706
            ||: .||.:..|.:::|    ||.:.|               :.:.|.:|:|.|.|....||
Human   677 QEKVHEMEKEHLNKVQT----ANEVKQAVEQQIQSHRETHQKQISSLRDEVEAKAKLITDLQ--- 734

  Fly   707 ANLSPNRRRGAFVSEPAILVKRTNSGSQIWTMEKLENKLIDMREMYQEHKERV---LNGLDEDNA 768
                 ::.:...:.:..:.|:.....:   |.::...||.::..| |:.:|:.   |.||:|..|
Human   735 -----DQNQKMMLEQERLRVEHEKLKA---TDQEKSRKLHELTVM-QDRREQARQDLKGLEETVA 790

  Fly   769 KPQDPFYESQENHNLIGVANIFLEVLFHDVKLDYHTPIISQQGEVAGRLQV--------EIERIA 825
            |      |.|..|||   ..:|::.|...||...........|..|.:.::        ::.::.
Human   791 K------ELQTLHNL---RKLFVQDLATRVKKSAEIDSDDTGGSAAQKQKISFLENNLEQLTKVH 846

  Fly   826 GQMPQDR---MCE-----------------------SVSESSGDSRDEYDDPVD 853
            .|:.:|.   .||                       ...|::...|..|...||
Human   847 KQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAKENASRDRKRYQQEVD 900

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	145/357 (41%)
		KISc	6..359	CDD:214526	145/355 (41%)
		Kinesin_assoc	356..468	CDD:292801	37/231 (16%)
		FHA	446..546	CDD:238017	22/124 (18%)
		KIF1B	741..786	CDD:289208	16/47 (34%)
		DUF3694	<1196..1252	CDD:289256
		CAP_GLY	1786..1850	CDD:279625
KIF5B	NP_004512.1	KISc_KHC_KIF5	6..325	CDD:276820	143/351 (41%)
		KISc	8..332	CDD:214526	145/356 (41%)
		DUF4337	<462..>538	CDD:290935	15/75 (20%)
		TACC	467..662	CDD:282818	46/249 (18%)
		TMPIT	598..>686	CDD:285135	28/145 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	908..963
		Globular	915..963
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910