DRSC/TRiP Functional Genomics Resources

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Protein Alignment Khc-73 and KIF3C

DIOPT Version :10

Sequence 1:NP_001261000.1 Gene:Khc-73 / 36718 FlyBaseID:FBgn0019968 Length:1957 Species:Drosophila melanogaster
Sequence 2:NP_002245.4 Gene:KIF3C / 3797 HGNCID:6321 Length:793 Species:Homo sapiens


Alignment Length:887 Identity:238/887 - (26%)
Similarity:389/887 - (43%) Gaps:259/887 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 ASDKIKVAVRVRPFNRREIELDTKCIVEMEKQ--QTILQNPPPLEKIERKQPKTFAFDHCFYSLN 64
            ||:.:||..|.||.:|:|.....:.|:.|:.:  |..|:||   .....:.||||.||..:    
Human     7 ASEALKVVARCRPLSRKEEAAGHEQILTMDVKLGQVTLRNP---RAAPGELPKTFTFDAVY---- 64

  Fly    65 PEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGT---QESKGIIPRLCDQ 126
               :..:.|..::|...|.::|:..||:|..:|||||||:||:|||.||   .|.:|:||...:.
Human    65 ---DASSKQADLYDETVRPLIDSVLQGFNGTVFAYGQTGTGKTYTMQGTWVEPELRGVIPNAFEH 126

  Fly   127 LFSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSY 191
            :|:.|:.....:  |.|..||:|||.|::.|||..:|.|: |:::|:...|.|:..||.....:.
Human   127 IFTHISRSQNQQ--YLVRASYLEIYQEEIRDLLSKEPGKR-LELKENPETGVYIKDLSSFVTKNV 188

  Fly   192 QDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQAT--GVSGE---KVSRMSLVDL 251
            ::|:::|..||::|.|.:|:||..||||||:|      |:|.:.:  |..|:   :|.:::||||
Human   189 KEIEHVMNLGNQTRAVGSTHMNEVSSRSHAIF------IITVECSERGSDGQDHIRVGKLNLVDL 247

  Fly   252 AGSERAVKT------------------------GAVGDRLKEGSNINKSLTTLGLVISKLADQSN 292
            |||||..|.                        ||.|:|.||.|.||.||:.||.||:.||    
Human   248 AGSERQNKAGPNTAGGAATPSSGGGGGGGGSGGGAGGERPKEASKINLSLSALGNVIAALA---- 308

  Fly   293 GKKSGNDKFVPYRDSVLTWLLKDNLGGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAV 357
            |.:|.:   :|||||.||.||:|:||||::|:||||:.|::.:|:|:|||||:|:|||.|.|...
Human   309 GNRSTH---IPYRDSKLTRLLQDSLGGNAKTIMVATLGPASHSYDESLSTLRFANRAKNIKNKPR 370

  Fly   358 VNEDPNARIIRELRHEVETLRSML-----------------KHATGSPVGDVQDKLAES------ 399
            |||||...::||.:.|:..|::.|                 |.|..:|.|..:..:.|:      
Human   371 VNEDPKDTLLREFQEEIARLKAQLEKRGMLGKRPRRKSSRRKKAVSAPPGYPEGPVIEAWVAEEE 435

  Fly   400 ----------------------ENLMKQISQTWEEK--LVKTER--IQNERQQALEKMGISVQAS 438
                                  ||.:::..:..||:  .::.:|  :..|:|:.||         
Human   436 DDNNNNHRPPQPILESALEKNMENYLQEQKERLEEEKAAIQDDRSLVSEEKQKLLE--------- 491

  Fly   439 GIKVEKNKYYLVNLNADPSLNELLVYYLK---DRTLIGGRTI----SGQQPDIQLSGLGI----- 491
                ||.| .|.:|..:....|||....|   .:.|||||.|    :.||..::|....|     
Human   492 ----EKEK-MLEDLRREQQATELLAAKYKAMESKLLIGGRNIMDHTNEQQKMLELKRQEIAEQKR 551

  Fly   492 -----QPEHCV---ITIEDSGLYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPK 548
                 |.|..:   .|:|..|.|                   |.||                   
Human   552 REREMQQEMMLRDEETMELRGTY-------------------TSLQ------------------- 578

  Fly   549 SNNTSMCASEPQTPAQLIDYNFARDEIMQNELSNDPIQTAIARLERQHEE------DKQVALEKQ 607
                    .|.:...:.:...:|:            :|...|.::.||:|      |.:.|..:|
Human   579 --------QEVEVKTKKLKKLYAK------------LQAVKAEIQDQHDEYIRVRQDLEEAQNEQ 623

  Fly   608 RQEYERQFQQLRNILSPSTPYAPYAPYDPLRMGKITPNTPTSQMRVEKWAQERDEMFRRSLGQLK 672
            .:|.:.::..:.|.:.|                                 :|::::..|.....:
Human   624 TRELKLKYLIIENFIPP---------------------------------EEKNKIMNRLFLDCE 655

  Fly   673 TDIMRANSLVQEANFLAEEMEKKTKFSVTLQIPPANLS---------PNRRRGAFVSEPAILVKR 728
            .:..:...|| .|...:.:|:|:...:|..:.|.:..:         |..|     :|..:.::.
Human   656 EEQWKFQPLV-PAGVSSSQMKKRPTSAVGYKRPISQYARVAMAMGSHPRYR-----AENIMFLEL 714

  Fly   729 TNSGSQIWTMEKLENKLIDMREMYQEHKERVLNGLDEDNAKP 770
            ..|...::.||...::..|.|.:   |.||::. ||....:|
Human   715 DVSPPAVFEMEFSHDQEQDPRAL---HMERLMR-LDSFLERP 752

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Khc-73NP_001261000.1 KISc_KIF1A_KIF1B 4..359 CDD:276816 148/388 (38%)
Kinesin_assoc 356..468 CDD:465047 33/163 (20%)
FHA_KIF13 446..547 CDD:438758 26/120 (22%)
KIF1B 741..786 CDD:463574 8/30 (27%)
DUF3694 989..1243 CDD:463599
CAP_GLY 1785..1850 CDD:460154
KIF3CNP_002245.4 KISc_KIF3 9..365 CDD:276822 146/381 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 251..288 7/36 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 394..424 5/29 (17%)
Smc <452..>635 CDD:440809 48/254 (19%)
Globular. /evidence=ECO:0000255 630..793 25/166 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 750..793 1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

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