Protein Alignment Khc-73 and Kif14

DIOPT Version :10

• Sequence 1: NP_001261000.1
• Gene: Khc-73 / 36718
• FlyBaseID: FBgn0019968
• Length: 1957
• Species: Drosophila melanogaster
• Sequence 2: NP_001414162.1
• Gene: Kif14 / 360849
• RGDID: 1310650
• Length: 1672
• Species: Rattus norvegicus
• Alignment Length: 1244
• Identity: 389/1244 - (31%)
• Similarity: 593/1244 - (47%)
• Gaps: 234/1244 - (18%)

  Fly     3 SDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYSLNPED 67
            :.::.||||||||::||.......:|....::..:::|      :.||..:|.:|..|:|.:...
  Rat   391 NSQVTVAVRVRPFSKREKTEKASQVVFRNGEEITVEHP------DMKQIYSFIYDVAFWSFDECH 449

  Fly    68 ENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCDQLFSAIA 132
            ..:|:|.||::.:...:||.||:|||.|:||||||||||||||||..|..|||||.|:.||:.||
  Rat   450 PGYANQTTVYETLAAPLLDRAFEGYNTCLFAYGQTGSGKSYTMMGLNEEPGIIPRFCEDLFAQIA 514

  Fly   133 NKSTPELMYKVEVSYMEIYNEKVHDLLDPK----PNKQSLKVREHNVMGPYVDGLSQLAVTSYQD 193
            .|...|:.|.:|:|:.|:||||:||||..|    ..||.|:||||.|.||||:|||...|:||.|
  Rat   515 KKQASEVSYHLEMSFFEVYNEKIHDLLVCKGENGQRKQPLRVREHPVSGPYVEGLSMNVVSSYSD 579

  Fly   194 IDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEK-----VSRMSLVDLAG 253
            |.:.:..|||.|..|||.||.:|||||:||::|:||..|:   .|.||:     .||::|:||||
  Rat   580 IQSWLELGNKQRATAATGMNDKSSRSHSVFTLVMTQTKTE---FVEGEEHDHRITSRINLIDLAG 641

  Fly   254 SERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLG 318
            |||.....:.|:|||||.:|||||.|||.|||.|::|:|||:    .|:|||:|.||||||::||
  Rat   642 SERCSTAHSSGERLKEGVSINKSLLTLGKVISALSEQANGKR----VFIPYRESTLTWLLKESLG 702

  Fly   319 GNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSMLKH 383
            |||:|.|:|||||:|.|.||||||||||.:|:.|||.|.||||.||::||||:.|:|.|::..|.
  Rat   703 GNSKTAMIATISPAASNIEETLSTLRYATQARLIVNVAKVNEDMNAKLIRELKAEIEKLKAAQKS 767

  Fly   384 ATG----------SPVGDVQDKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQAS 438
            :..          ..:..::.||.:.|..|.:|.:.|:||..:.|:.:.:..:.|:|.|::.|
  Rat   768 SRNIDPERYRLCRQEISSLRMKLHQQERDMAEIQRVWKEKFEQAEKRKLQETKELQKAGVTFQ-- 830

  Fly   439 GIKVEKNKYYLVNLNADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVITIEDS 503
               ::.:...|||||.||.|:|:|:|.:|:.....|:.......||||||:.|..:||.|.....
  Rat   831 ---MDNHLPNLVNLNEDPQLSEMLLYMVKEGITTVGKHTPNSSHDIQLSGVLIADDHCTIRSYGG 892

  Fly   504 GLYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSP-------KSNNTSMCASEPQT 561
            .:.:.|...|:.:|||....|.|.|.:|||::.|..|:||.|.|       |::..::.:..|:
  Rat   893 TVSIVPAGEAKTYVNGMHISEPTVLHHGDRVVLGGDHYFRFNHPVEVQKGKKTSRNNLTSEGPK- 956

  Fly   562 PAQLIDYNFARDEIM---------------------------------QNELSND--PIQTAIAR 591
                 |:.||::|::                                 |.|||:.  ..:..|..
  Rat   957 -----DFEFAKNELLAAQRSRLEAEIKDAQLKAKEEMMQGIQIAKEMAQQELSSQRAAYENKIRA 1016

  Fly   592 LERQHEEDKQ----------------VALEKQRQEYERQFQQLRNILSPSTPYAPYAPYD-PLRM 639
            ||.:..|:.|                ..|||.:|..|::....:..|...|.....|..| .:|.
  Rat  1017 LEAELREESQRKRLEEINNQKASHKIEELEKAKQHLEQEVYVNKRRLEMETLATKQALEDHRIRH 1081

  Fly   640 GKITPNTPTSQMRVEKWAQ-------ERDEMFRRSLGQLKTDIMRANSLVQEANFLAEEMEKKTK 697
            .:|.......:.::.:..|       .|::.|..   |.....|:.::::||||.::::.:|...
  Rat  1082 ARILEALEREKQKIAEEVQILQENRGNRNKTFTI---QPNWSSMKLSTMIQEANAISDKFKKHYV 1143

  Fly   698 FSVTLQIPPANLSPNRRRGAFVSEPAILVKRTNSG-SQIWTMEKLENKLIDMREMYQEHKERVLN 761
            |.       .:.:.::.|    |:|::.|:....| |..|.:||.|:||..|:::|:.:..  ..
  Rat  1144 FG-------RHDASDKGR----SDPSVRVRNLQLGISTFWNLEKFESKLAAMKDLYESNSG--TR 1195

  Fly   762 GLD-----EDNAKP---QDPFYESQENHNLIGVANIFLEVLFHDVKLDYHTPIISQQGEVAGRLQ 818
            |.|     ||..:|   ..|........:...:.|..:....||:.     ||.|........|.
  Rat  1196 GEDVFCDPEDEWEPDITSTPVSSLSRRRSRSLMKNRRVSGCLHDIH-----PIQSMHPSHTSGLM 1255

  Fly   819 VEIERIAGQMPQD---RMCESVSESS----GDSRDEYDDPVDPTSNQITCRVTIKCASGLPLSLS 876
            .:...|.....:.   .:|:.:..||    |.|.||.....|...|.:             |.|.
  Rat  1256 EKPSTIYSNSSESFLPGICKELIGSSIDFLGQSFDEEKTIADSLINNL-------------LKLY 1307

  Fly   877 NFVFCQYTFWGHQEMVVPVINAESTAHDQNMVFKFEHTQDFTVTINEEFLEHCIEGALSIEVWGH 941
            |.|.                 |.|.||::    :.|.:||      ..|.:...: ||:|:|
  Rat  1308 NGVI-----------------AISKAHEE----QDEESQD------NVFSDRAAQ-ALTIQV--- 1341

  Fly   942 RSAGFSKTKGWEVEQQQAKARSLVDRWAELSRKIELWVEIHELNDNGEYSPVEVTNRNEV-LTGG 1005
             :..|        ||.....:..:|.:...|....|..|:                |.:: ..||
  Rat  1342 -ACAF--------EQLVVLFKHWLDDFPPCSGSARLEEEL----------------RQDIKKLGG 1381

  Fly  1006 IYQL-RQGQQRRVNVRVKPVQNSGTLPIICQSIVNVAIGSVTVRSRLQRPLDSYQ----EEDLTV 1065
            ..|| .||....::..||..||..| .||.|::.:||..:|...|:|....||.:    :|.:..
  Rat  1382 YLQLFLQGCCSDISSMVKEAQNKVT-EIIQQAVGHVAQLAVLKGSKLCVLEDSNKVSSAQELMAA 1445

  Fly  1066 LREKWSEALGRRRQYLDQQIQMLIKKEEKNEQERERELSLVHQWVSLTEERNAVLVPAPGSGIPG 1130
            |::..:..:   |..||..::        ..||..:::|.......:|.:..|..|...|| :..
  Rat  1446 LQDGTASGM---RSLLDSGLE--------TAQELRQDVSRQSAPEEVTRQMKANAVELVGS-LEN 1498

  Fly  1131 APASWEPPS 1139
            ..|.|...|
  Rat  1499 IFAEWRTKS 1507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	187/363 (52%)
		Kinesin_assoc	356..468	CDD:465047	39/121 (32%)
		FHA_KIF13	446..547	CDD:438758	39/100 (39%)
		KIF1B	741..786	CDD:463574	11/52 (21%)
		DUF3694	989..1243	CDD:463599	38/157 (24%)
		CAP_GLY	1785..1850	CDD:460154
Kif14	NP_001414162.1	None