Protein Alignment Khc-73 and Kif15

DIOPT Version :10

• Sequence 1: NP_001261000.1
• Gene: Khc-73 / 36718
• FlyBaseID: FBgn0019968
• Length: 1957
• Species: Drosophila melanogaster
• Sequence 2: XP_038937602.1
• Gene: Kif15 / 353302
• RGDID: 727790
• Length: 1396
• Species: Rattus norvegicus
• Alignment Length: 1536
• Identity: 361/1536 - (23%)
• Similarity: 617/1536 - (40%)
• Gaps: 430/1536 - (27%)

  Fly     4 DKIKVAVRVRPFNRREIELD---TKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYSLNP 65
            |.|||.||:||........|   :.|:..:.:....|.:.|        .||||.||   |....
  Rat    25 DAIKVFVRIRPAEEGARSADGEQSLCLSVLSQTALRLHSNP--------DPKTFVFD---YVAGM 78

  Fly    66 EDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQES-------KGIIPRL 123
            :    .:||:||..|.:.|:::...|||..|||||||||||::||||..:|       :|:|||.
  Rat    79 D----TTQESVFSTVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSDSDNFSHNLRGVIPRS 139

  Fly   124 CDQLFSAI--------ANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYV 180
            .:.|||.|        |.||     :..:.|::|:|||:::||||..  ...|.:|||...|.:|
  Rat   140 FEYLFSLIDREKEKAGAGKS-----FLCKCSFIEVYNEQIYDLLDSA--SVGLYLREHIKKGVFV 197

  Fly   181 DGLSQLAVTSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSR 245
            .|..:..|.|..:...:::.|.::|.||:|:||.|||||||||::.:..:  ::::.....:.|.
  Rat   198 VGAVEQVVASAAEAYQVLSRGWRNRRVASTSMNRESSRSHAVFTITIESM--EKSSEAVNIRTSL 260

  Fly   246 MSLVDLAGSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLT 310
            ::|||||||||...|.|.|.||||..|||:||:.||.||:.|.|..|||:    :.|.||||.||
  Rat   261 LNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVITALVDVGNGKQ----RHVCYRDSKLT 321

  Fly   311 WLLKDNLGGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVE 375
            :||:|:||||::|.::|.:.|.:..:.||||||.:|.|||.|.|.||||||.... :.:|:.||:
  Rat   322 FLLRDSLGGNAKTAIIANVHPGSRCFGETLSTLNFAQRAKLIKNKAVVNEDTQGN-VSQLQAEVK 385

  Fly   376 TLRSMLKHAT------GSPVGDVQDKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGIS 434
            .||..|...|      ||.:  .:||  |..|.|    :.:.|.::..::.:.|::..:||:
  Rat   386 RLREQLSQFTSGQLTPGSSL--ARDK--EKANYM----EYFLEAMLFFKKSEQEKKSLVEKI--- 439

  Fly   435 VQASGIKVEKNKYYLVNLNADPSLNELLVYYLKDRTL--------IGGRTISGQQPDI------Q 485
            .|...:.::|.|:.        ..|:::|.:.:|:.:        ..|..:..:|..:      :
  Rat   440 TQLEDLTLKKEKFI--------QSNKMIVKFREDQIMRLERLQKEARGSFLPEEQDRLLSELRDE 496

  Fly   486 LSGLGIQPEH----CVITIEDSGLYME--------PVQGA-RCFVNGSAAVEKTPLQNGDRILWG 537
            :..|..|.||    ....:|:..|..|        ||:.| .......|.:|:.
  Rat   497 IRTLREQVEHHPRLAKYAMENHSLREENRKLKLLAPVKRAHELDAQAIARLEQA----------- 550

  Fly   538 NHHFFRVNSPKSNNTSMCASEPQT---PAQLIDYNFARDEIMQNELSNDPIQTAIARLERQHEE- 598
               |..|:|.::|:..:....|:.   |:........:.:::|       |||.:...::::||
  Rat   551 ---FSEVSSTETNDKGLQGLPPKAIKEPSFFTSTEKLKVQLLQ-------IQTELNNSKQEYEEF 605

  Fly   599 -----DKQVALEKQRQEYERQFQQLRNILSP-----------------------STPYAPY---- 631
                 .||:.||.:.|..::....|.|:|..                       :||...|
  Rat   606 KELTRKKQLELESELQSLQKANLNLENLLEATKVCKRQEVSQLNKIHAETLKIITTPTKAYQLCS 670

  Fly   632 --APYDPLRMGKI----TPNTPTSQMRVEKWAQERDEMFRRSLGQLKTDIMRANSLVQEANFLAE 690
              .|.....:|..    :.:.|.:.:..|....|..|....::.:....:....|::|..  |.|
  Rat   671 RLVPKSSPEVGSFGFLRSQSAPDNDILNEPVPPEMSEQALEAISEELRTVQEQLSVLQVK--LDE 733

  Fly   691 EMEKKTKF----------SVTLQ---IPPANLSPNRRRGAFVSEPAILVKRTNSGSQIWTMEKLE 742
            |..|..|.          |..:|   .|..:|.|               |..:|....|:.::.:
  Rat   734 EEHKNLKLQQNVDRLEHHSTQMQEHTSPVCSLFP---------------KLFSSERSDWSKQQQD 783

  Fly   743 --NKLIDMREMYQEHKERVLNGLDEDNAKPQDPFYESQENHNLIGVANIFLEVLFHD-------- 797
              .:|.|:.:..|:.:.:                             |.||:...||
  Rat   784 YLTQLSDLEKQLQDAQTK-----------------------------NDFLKCEVHDLRIVLNSA 819

  Fly   798 ------VKLDYHTPIISQQGEVA----GRLQVEIERIAGQMPQDRMCESVSESSGDSRDEYDD-- 850
                  |||:|.|...||:.|::    ..:||:::....::..:::.    ||....:|.||:
  Rat   820 DKELSLVKLEYSTFKESQEKELSQLSERHVQVQLQLDNARLENEKLL----ESQACLQDSYDNLQ 880

  Fly   851 -----PVDPTSNQI-TCR---VTIKCASGLPLSLSNFVFCQYTFWGHQEMVVPVINAESTAHDQN 906
                 .||..|..: .|:   .|:|.      .|.|              :|.:..||...:::
  Rat   881 EVMKFEVDQLSKNLQNCKQENETLKS------DLHN--------------LVELFEAEKERNNK- 924

  Fly   907 MVFKFEHTQDFT--------VTINEEFLE---HCIEGALSIEVWGHRSAGFSKTKGWEVEQQQAK 960
            :..:||..::.:        .|:.:|..|   .|.:....::               |:|:....
  Rat   925 LSLQFEEDKENSSKEILKALETVRQEKQEEMARCEKQMAKVQ---------------ELEESLLA 974

  Fly   961 ARSLVDRWAELSRKIE------LWVEIHELNDN-GEYSPVEVTNRNEV------LTGGIYQLRQG 1012
            |.::|. ..|.||:.:      |..:|.||..: ||.|....|.:.|:      .|..:....:.
  Rat   975 AENVVS-CLEKSRESDKELVTNLMNQIQELRTSAGEKSEAIDTLKQELQDISCKYTAAVADKEES 1038

  Fly  1013 QQ--RRVNVRVKPVQNSGTLPI---------ICQSIVNVA--IGSVTVRSRLQRPLDSYQEEDLT 1064
            ::  ||..|.:..::.:..|.|         :|:.:.:..  :..:|..|:....|....:|:||
  Rat  1039 KELIRRQEVDILELKETLRLRILSEDIERDMLCEDLAHATEQLNMLTEASKKHSGLLQSAQEELT 1103

  Fly  1065 VLREKWSEALGRRRQYLDQQIQMLIKKEEKNEQERERELSLVHQWVSLTEERNAVLVPAPGSGIP 1129
                        :::.|.|::|..:.:|::..::::.|.:|          :...|....||. |
  Rat  1104 ------------KKEALIQELQHKLNQEKEEVEQKKSEYNL----------KMKQLEHVMGSA-P 1145

  Fly  1130 GAPASWEPPSGMEPHVPVLFLNLNGDDLSAQNTNDELSVAGINSILSKEH-------GHKFYTLQ 1187
            ..|.|.:.|...:.|:..|.      :...|...|     |..|.:|.:|       ..:....:
  Rat  1146 EYPQSPKTPPHFQTHLAKLL------ETQEQEIED-----GRASKMSLQHLVTKLNEDREVKNAE 1199

  Fly  1188 ILQHLDKDVCCVASWDSSMHDSQALNRVTEANERVYLI---------LRTTVRLSHPAPMDL--- 1240
            ||:.  ||..|  ..::...:||.|      .||.:|:         .|.:...|.|....|
  Rat  1200 ILRM--KDQLC--EMENLRLESQQL------RERTWLLQTQLDDMKRQRESSSQSRPDSQQLKNE 1254

  Fly  1241 ----VLRKRLSIN------------IKKGQTLTDRLKKFRLVRGENAIWQSGVTYEVVSNIPKAS 1289
                ::|:||:.|            :::.|:..|..:||                     ..:.|
  Rat  1255 YEEEIIRERLAKNKLIEEMLKMKTDLEEVQSALDSKEKF---------------------CHRMS 1298

  Fly  1290 EELEDRESLAQLAASGDDCSASDGETYIEKYTRGVSAVESI 1330
            ||:|...:|...|....:...|..|...|:..|....:|.:
  Rat  1299 EEVERTRTLESRAFQEKEQLRSKLEEMYEERERTCQEMEML 1339

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	151/372 (41%)
		Kinesin_assoc	356..468	CDD:465047	29/117 (25%)
		FHA_KIF13	446..547	CDD:438758	20/127 (16%)
		KIF1B	741..786	CDD:463574	3/46 (7%)
		DUF3694	989..1243	CDD:463599	53/295 (18%)
		CAP_GLY	1785..1850	CDD:460154
Kif15	XP_038937602.1	KISc_KLP2_like	25..373	CDD:276824	154/375 (41%)
		COG5022	<425..961	CDD:227355	107/638 (17%)
		SMC_prok_B	<704..1386	CDD:274008	141/788 (18%)