Protein Alignment Khc-73 and neb

DIOPT Version :10

• Sequence 1: NP_001261000.1
• Gene: Khc-73 / 36718
• FlyBaseID: FBgn0019968
• Length: 1957
• Species: Drosophila melanogaster
• Sequence 2: NP_476817.1
• Gene: neb / 35293
• FlyBaseID: FBgn0004374
• Length: 1121
• Species: Drosophila melanogaster
• Alignment Length: 1036
• Identity: 329/1036 - (31%)
• Similarity: 501/1036 - (48%)
• Gaps: 197/1036 - (19%)

  Fly     8 VAVRVRPFNRREI---ELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYSLNPEDEN 69
            |||||||.|..|.   ::.....|.....:..:|.....: ........|::|..:||.:||.:|
  Fly   123 VAVRVRPLNALECTRGQVTNVVQVHGNSNELTVQAGSSAD-ASAGVTHFFSYDQVYYSCDPERKN 186

  Fly    70 FASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQ-------------ESKGIIP 121
            ||.|..||:...|.::|.||:|||||:||||||||||||:|||.:             :..||||
  Fly   187 FACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGIEALDDAALDGGPPHDEAGIIP 251

  Fly   122 RLCDQLFSAI-ANKSTPELMYKVEVSYMEIYNEKVHDLL----------DPKPNKQ-------SL 168
            |.|.:||..| |.||..:|..:|||||.||||||:||||          :..|.:|       :|
  Fly   252 RFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQHAAAATGESTPIQQQQQQQRPAL 316

  Fly   169 KVREHNVMGPYVDGLSQLAVTSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTD 233
            |||||.:.||||..||..:|.||..:.|.:..||..|..|:|.||.:|||||::|::||.  |||
  Fly   317 KVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATASTAMNDKSSRSHSIFNIVLN--LTD 379

  Fly   234 QAT--GVSGE------------KVSRMSLVDLAGSERAVKTGAVGDRLKEGSNINKSLTTLGLVI 284
            .::  |:|.:            :.|::||||||||||...:|:.|:|::||.:|||||.|||.||
  Fly   380 LSSDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGSNGERIREGVSINKSLLTLGKVI 444

  Fly   285 SKLADQ----SNGK-KSGN-DKFVPYRDSVLTWLLKDNLGGNSRTVMVATISPSADNYEETLSTL 343
            :.|||.    :||. .||. ..|||||:|||||||::||||||:|||:|||||::.:.:|||:||
  Fly   445 AALADSRKAIANGPLGSGTPSTFVPYRESVLTWLLRENLGGNSKTVMLATISPASIHADETLATL 509

  Fly   344 RYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSM---------LKHATGSP----------- 388
            |||.:|:.|||...|||.|:.:|||:||.||:.|:|:         |...:.:|
  Fly   510 RYACKARSIVNRVKVNESPHDKIIRDLRAEVDRLKSLRNEYERQRRLSGNSNNPVPRKIIIETSV 574

  Fly   389 ----VGDVQDKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQASGIKVEKNKYYL 449
                |..::.:|||.|..:.:..::|.|||.:.|..:....:.|::.|::::   :..|:.:..|
  Fly   575 DETEVEALRQQLAERERELSRAQKSWMEKLKEAEDQRKSELRVLKRRGLALE---LTAEQKQACL 636

  Fly   450 VNLNADPSLNELLVYYLKDRTLIGGR-----TISGQQPDIQLSGLGIQPEHCVITIEDSG-LYME 508
            |||.|||.|:..|.|.|....:..||     ..|..||||.|.|..:..:||.|..|..| ||:.
  Fly   637 VNLTADPILSGTLFYLLPQGLVRIGRGRLPGGSSSSQPDIVLDGPLVALQHCSIEHERGGKLYVI 701

  Fly   509 P-VQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNTSMCASEPQTPAQLIDYNFAR 572
            | .:....:|||....::..|.:|||::.|..|:||:::|..:.... |..|      :|:..|.
  Fly   702 PGSEDFETYVNGELLKDRRQLFHGDRLVIGGSHYFRISNPFCSQRGK-ADHP------VDFQLAH 759

  Fly   573 DEIMQNELSNDPIQTAIARLERQHEEDKQVAL---EKQRQEYERQFQQLRNILS----------- 623
            .||:|.:..         :|..:.|.:|:.||   |::|.::.|.|::....|.
  Fly   760 QEILQKQEQ---------QLRSELEAEKRAALTKIEQERAQHARDFEERLQCLELEQFKYKCNSE 815

  Fly   624 ------PSTPYAPYAPYDPLRMGKITPNTPTSQMRVEKWAQERDEMFRRSLGQLKTDIMRANSLV 682
                  .:...|....:.||| .:...:||..:..:      .:::.|..|...:..:.:...:|
  Fly   816 MLETERQALALAQQQEHTPLR-HEDAVSTPAQKSTI------LEDIQRIMLNPSEESLHKTQLMV 873

  Fly   683 QEANFLAEEMEKKTKFSVTLQIPPANLSPNRRRGAFVSEPAILVKRTNSGSQIWTMEKLENKLID 747
            :||.....:::...:|..| |.|.       ..|...:...||.|:....:: |...:|
  Fly   874 KEATQRCRQLDLPLEFRQT-QTPD-------EFGLLRTVILILDKQRGLKAE-WPTARL------ 923

  Fly   748 MREMYQEHKERVLNGLDEDNAKPQDPFYESQENHNLIGVANIFLEVLFHDVKLDYHTPIISQQGE 812
                      .|...|..|||       |.||..|        ...:|..|::|:. |:.:...|
  Fly   924 ----------GVWLDLVRDNA-------EQQEKLN--------ATTIFQSVEVDWE-PLDADLNE 962

  Fly   813 V------AGRLQVEIERIAGQM---PQDRMCESVSESSGDSRDEYDDPVDPTSNQI--TCRVTIK 866
            .      :.|:.:.:..:...:   |..|:..:.|..|...| :...| .|.|..:  |.|:...
  Fly   963 TLSDTHNSSRIALNLSAMKDVLLNKPLKRLLNASSSKSNTPR-QTSTP-SPGSQLVHFTKRLLTY 1025

  Fly   867 CASGLPLSLSNFVFCQYTFWGHQEMVVPVINAES-TAHDQNMVFKFEHTQD---FTVTINE 923
            ....:|.|.|:|     |....||:.:...:|:. ..|.:..:.:.|:.||   ..|::.|
  Fly  1026 DPEEIPESQSSF-----TTLVQQELQIMQRSAQRLRRHCEAALLERENHQDNGVLAVSLQE 1081

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	184/404 (46%)
		Kinesin_assoc	356..468	CDD:465047	39/135 (29%)
		FHA_KIF13	446..547	CDD:438758	39/107 (36%)
		KIF1B	741..786	CDD:463574	10/44 (23%)
		DUF3694	989..1243	CDD:463599
		CAP_GLY	1785..1850	CDD:460154
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	184/404 (46%)
		SMC_N	514..>615	CDD:481474	29/100 (29%)
		FHA_KIF14	627..741	CDD:438759	40/113 (35%)