DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Khc-73 and CG14535

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	NP_001285726.1	Gene:	CG14535 / 34073	FlyBaseID:	FBgn0031955	Length:	1131	Species:	Drosophila melanogaster

Alignment Length:	984	Identity:	202/984 - (20%)
Similarity:	339/984 - (34%)	Gaps:	312/984 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KIKVAVRV--RPFNRREIELDTKCIVEMEKQQTILQN----PPPLEKIER----KQPKTFAFDHC 59
            |:||.:||  |..|....|.|...:.:.::|.|:...    |||....||    ..||.||||:.
  Fly    44 KVKVMLRVADRDRNSGGTEPDFMALDKKKRQVTLTDPRTACPPPQAAQERAPMVAAPKMFAFDNL 108

  Fly    60 FYSLNPEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMM------------- 111
            |...:.:.:..||..:       .::....:|.:.|:.|.|...:|::.|::
  Fly   109 FTGEDKQSDVCASALS-------EVIPAVLEGSDGCLLAMGYPATGQAQTVLGELGGGSGSGSAS 166

  Fly   112 --GTQESKGIIPRLCDQLFSAIANKSTPE-LMYKVEVSYMEIYNEK----VHDLL-------DPK 162
              |...|.|..|.....|:..|..:.... ..:.|.||.:.:...|    ..|||       |..
  Fly   167 GSGVACSLGAAPCAIAWLYKGIQERRQKSGARFSVRVSAVGVSATKPDALSQDLLISHAAESDDS 231

  Fly   163 PNKQSLKVREHNVMGPYVDGLSQLAVTSYQD----IDNLMTEGNKS--RTVAATNMNAESSRSHA 221
            |   .:.:|:..:.||     ::|...:.:.    :|:.:....||  .|.:.::..|....|..
  Fly   232 P---GIYLRDDFLGGP-----TELRAPTAERAALFLDSALAGRLKSSGSTASGSSGCAAPLESAL 288

  Fly   222 VFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSERAVKTGAVGDRLKEGSNINKSLTTLG---LV 283
            :|::.:.|....:..||:|.: ||:.::||.|.                :|.|..|...|   ::
  Fly   289 IFTLHVYQYSLSRKGGVAGGR-SRLHIIDLGGC----------------ANRNGGLPLSGIGNIL 336

  Fly   284 ISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLGG-NSRTVMVATISPSADNYEETLSTLRYAD 347
            ::.|:.|         :..|::|..||.||||.|.. .....:||.:.|. .:|::.|||::.|.
  Fly   337 LAILSGQ---------RHPPHKDHPLTPLLKDCLAPITCHVAIVAHVRPE-QSYQDALSTIQIAS 391

  Fly   348 RAKRIVNHAVVNEDPNARIIRELRHEVETLRSMLKHATGSPVGDVQDKLAESENLMKQISQTWEE 412
            |..|               :|..:|.|.     :..|.|         ||
  Fly   392 RIHR---------------LRRRKHRVP-----MPLAVG---------LA--------------- 412

  Fly   413 KLVKTERIQNERQQALEKMGISVQASGIKVEKNKYYLVNLNADPSLNEL---LVYYL---KDRTL 471
                         |.|...|.|. .||              ||||.:|:   .|.|:   .|.|
  Fly   413 -------------QGLGGNGSSA-GSG--------------ADPSSSEISADTVIYMGPNDDAT- 448

  Fly   472 IGGRTISGQQPDIQLSGLGIQPEHCVIT--IEDSGLYMEPVQGARCFVNGSAAVEKTPLQNGDRI 534
                  .|:.|.:.|..|.......|::  ::.|||...|.:.|.   |....::|.......:.
  Fly   449 ------DGEHPPVYLPSLTAGDNRGVMSKALKGSGLEKPPSKSAS---NSPMMMKKAMAAEKAKK 504

  Fly   535 LWGNHHFFRVNSPKSNNTSMCASEPQTPAQLIDYNFARDEIMQNELSNDPIQTAIARLERQHEED 599
            |.|:|    ..|.|....:...|.|..|          .|..|.:....||...      :|...
  Fly   505 LPGSH----TGSLKRQAGAGACSSPMIP----------HEQPQIQAMGSPIPIP------RHMVS 549

  Fly   600 KQVALEKQRQEYERQFQQLRNILSPSTPYAPYAPYDPLRMG--KITPNTPTSQMRVEKWAQERDE 662
            |...:...:.             ||.....|.|..:.|..|  |||.         |:|. :...
  Fly   550 KGSMVPSPKG-------------SPMRRAHPGAALEQLEAGMRKITE---------EQWI-DGPR 591

  Fly   663 MFRRSLGQLKTDIMRANSLVQEANFLAEEMEKKTKFSVT-LQIPPANLSPNRRRGAFVSEPAILV 726
            :.|..:.:.: .:||..:.|::.....:..:.::..|:| ..:|.|..|..:..|...:....::
  Fly   592 VSRAKVAEAR-HLMREVNHVKQCETWVDGPKSQSCRSLTACNLPAAGGSQTQGYGFMDAHKKTMI 655

  Fly   727 KR--TNSGSQI---------------WTMEKLENKLIDM--REMYQEHKERVLN----------- 761
            ::  .|..:|:               |.:.:|:.|.:|:  |..:.......||
  Fly   656 RQWVENQTTQVFQSTVSASNSPTALHWKLSQLKQKSLDLPDRPAFNPEPSLDLNQPCFESLPLLD 720

  Fly   762 -----GLDEDNAKP----------QDPFYE---SQEN-HNLIGVANIFLEVLFHDVKL------D 801
                 |.:::::.|          .||...   ||:| |.::. .::..|.| |:.:|      .
  Fly   721 PAPPDGDEDEDSGPSEVPPALPLLDDPLGSRDISQDNLHRMLS-RHVSREQL-HEAELVASRASS 783

  Fly   802 YHTPIISQQGEVAGRLQVEIERIAGQMPQDR--------------------------MCESVSES 840
            .|.|  ||:....| |||..|.||..|.:||                          .|||.||.
  Fly   784 SHHP--SQRSIDCG-LQVTEEEIARTMSRDRDHDPSAHPLSALSHCDNISFVSSFNMACESFSEC 845

  Fly   841 SGDSRDEYD 849
            ...:|.::|
  Fly   846 GERARQQFD 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	91/400 (23%)
		KISc	6..359	CDD:214526	90/399 (23%)
		Kinesin_assoc	356..468	CDD:292801	20/117 (17%)
		FHA	446..546	CDD:238017	24/107 (22%)
		KIF1B	741..786	CDD:289208	14/76 (18%)
		DUF3694	<1196..1252	CDD:289256
		CAP_GLY	1786..1850	CDD:279625
CG14535	NP_001285726.1	Motor_domain	44..394	CDD:277568	90/391 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100