Protein Alignment Khc-73 and KIF1B

DIOPT Version :10

• Sequence 1: NP_001261000.1
• Gene: Khc-73 / 36718
• FlyBaseID: FBgn0019968
• Length: 1957
• Species: Drosophila melanogaster
• Sequence 2: NP_001352880.1
• Gene: KIF1B / 23095
• HGNCID: 16636
• Length: 1816
• Species: Homo sapiens
• Alignment Length: 1965
• Identity: 564/1965 - (28%)
• Similarity: 831/1965 - (42%)
• Gaps: 588/1965 - (29%)

  Fly     1 MASDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYS-LN 64
            |:...:||||||||||.||...::|||::|:...|.:.||    |..::.||:|:||:.::| .:
Human     1 MSGASVKVAVRVRPFNSRETSKESKCIIQMQGNSTSIINP----KNPKEAPKSFSFDYSYWSHTS 61

  Fly    65 PEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESK--GIIPRLCDQL 127
            |||..||||..|::.:|:.:|.:||:|||.|||||||||:||||||||.||..  ||||:||::|
Human    62 PEDPCFASQNRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEESQAGIIPQLCEEL 126

  Fly   128 FSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQ 192
            |..|.:....|:.|.|||||||||.|:|.|||:|| ||.:|:||||.::||||:.||:||||||.
Human   127 FEKINDNCNEEMSYSVEVSYMEIYCERVRDLLNPK-NKGNLRVREHPLLGPYVEDLSKLAVTSYT 190

  Fly   193 DIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSERA 257
            ||.:||..|||:|||||||||..||||||||::|.||...|..|.:|.||||::|||||||||||
Human   191 DIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKHDNETNLSTEKVSKISLVDLAGSERA 255

  Fly   258 VKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSN----GKKSGNDKFVPYRDSVLTWLLKDNLG 318
            ..|||.|.|||||:||||||||||.|||.||:..|    .||.....|:|||||||||||::|||
Human   256 DSTGAKGTRLKEGANINKSLTTLGKVISALAEVDNCTSKSKKKKKTDFIPYRDSVLTWLLRENLG 320

  Fly   319 GNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSML-- 381
            |||||.|||.:||:..||:|||||||||||||:|..:||:||||||:::|||:.||..|:.:|
Human   321 GNSRTAMVAALSPADINYDETLSTLRYADRAKQIKCNAVINEDPNAKLVRELKEEVTRLKDLLRA 385

  Fly   382 ------------------------------KH---------------------ATGSP------- 388
                                          ||                     .|.||
Human   386 QGLGDIIDIDPLIDDYSGSGSKYLKDFQNNKHRYLLASENQRPGHFSTASMGSLTSSPSSCSLSS 450

  Fly   389 ------VGDVQ-------------DKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGIS 434
                  |..:|             ::|.|||.::.::::||||||.|||.|:.||:..|.:||::
Human   451 QVGLTSVTSIQERIMSTPGGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMEREALLAEMGVA 515

  Fly   435 VQAS----GIKVEKNKYYLVNLNADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEH 495
            ::..    |:...|...:|||||.||.::|.|:||:||.....|:..:.::.||.|||..|:.||
Human   516 IREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGQADAERRQDIVLSGAHIKEEH 580

  Fly   496 CVITIEDSG-----LYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNTSM- 554
            |:...|.|.     :.:||.:.:..:|||....:...|::|:||:.|.:|.||.|.|:......
Human   581 CIFRSERSNSGEVIVTLEPCERSETYVNGKRVSQPVQLRSGNRIIMGKNHVFRFNHPEQARAERE 645

  Fly   555 CASEPQTPAQLIDYNFARDEIMQNELSNDPIQTAIARLE------RQHEEDKQVALEKQRQEYER 613
            .....:||::.:|:.||:.|:::.: ..|..|....||:      ::.:|:..:.||:||.:||.
Human   646 KTPSAETPSEPVDWTFAQRELLEKQ-GIDMKQEMEKRLQEMEILYKKEKEEADLLLEQQRLDYES 709

  Fly   614 QFQQLRNILSPSTPYAPYAPYDPLRMGKITPNTPTSQMRVEK--WAQERDEMFRRSLGQLKT--- 673
            :.|.|:.               .:....:...|...:...|:  |.|...|:.:.:..:.|:
Human   710 KLQALQK---------------QVETRSLAAETTEEEEEEEEVPWTQHEFELAQWAFRKWKSHQF 759

  Fly   674 ----DIMRANSL-VQEANFLAEEMEKKTKFSV-----TLQIP-PANLSPNRRRGAFVSEP----- 722
                |::..|:: ::|||.::.|::||.:|..     ||..| |..|.|..........|
Human   760 TSLRDLLWGNAVYLKEANAISVELKKKVQFQFVLLTDTLYSPLPPELLPTEMEKTHEDRPFPRTV 824

  Fly   723 -AILVKRTNSG-SQIWTMEKLENKLIDMREMY----------QEHKERVLNGLD----------- 764
             |:.|:...:| :..|::|||:.:|..|||||          |:..|..:.|.|
Human   825 VAVEVQDLKNGATHYWSLEKLKQRLDLMREMYDRAGEMASSAQDESETTVTGSDPFYDRFHWFKL 889

  Fly   765 ---------------------------------------------EDNA---------------- 768
                                                         :|.|
Human   890 VGSSPIFHGCVNERLADRTPSPTFSTADSDITELADEQQDEMEDFDDEAFVDDAGSDAGTEEGSD 954

  Fly   769 ---KPQDPFYESQENHNLIGVANIFLEVLFHDVKLDYHTPIISQQGEVAGRLQVEIERIA----- 825
               ...||||:......|:|.|.::|..|.:.|.|.:...|:|::|||.|.|:|.::.||
Human   955 LFSDGHDPFYDRSPWFILVGRAFVYLSNLLYPVPLIHRVAIVSEKGEVRGFLRVAVQAIAADEEA 1019

  Fly   826 ------------------------GQMPQDRMCES--------VSESSGDSRDEYDDP------- 851
                                    .......|..|        :.|..|.|.:....|
Human  1020 PDYGSGIRQSGTAKISFDNEYFNQSDFSSVAMTRSGLSLEELRIVEGQGQSSEVITPPEEISRIN 1084

  Fly   852 ---------------VDPTSNQI----------TCRVTIKCASGLPLSLSNFVFCQYTF-WGHQE 890
                           ::..|.:|          |.|||:..|||:....:: :|||:.| ..|.|
Human  1085 DLDLKSSTLLDGKMVMEGFSEEIGNHLKLGSAFTFRVTVLQASGILPEYAD-IFCQFNFLHRHDE 1148

  Fly   891 --MVVPVINAESTAHDQNMVFKFEHTQDFTVTINEEFLEHCIEGALSIEVWGHRSAGFSKTKGWE 953
              ...|:.|     :.:.....|.|.|:..|.|.|.|:::.....:..||:||........:|.|
Human  1149 AFSTEPLKN-----NGRGSPLAFYHVQNIAVEITESFVDYIKTKPIVFEVFGHYQQHPLHLQGQE 1208

  Fly   954 VEQQQAKARSLVDRWAELSRKIE----------------------LWVEIHELNDNGEYSPVEVT 996
            :.......|........||:.:.                      :|.||.||...|||.|..|.
Human  1209 LNSPPQPCRRFFPPPMPLSKPVPATKLNTMSKTSLGQSMSKYDLLVWFEISELEPTGEYIPAVVD 1273

  Fly   997 NRNEVLTGGIYQLRQGQQRRVNVRVKPVQNSGTLPIICQSIVNVAIGSVTVRSRLQRPLDSYQEE 1061
            :...:...|.:.|.||.|||:.|
Human  1274 HTAGLPCQGTFLLHQGIQRRITV------------------------------------------ 1296

  Fly  1062 DLTVLREKWSEALGRRRQYLDQQIQMLIKKEEKNEQERERELSLVHQWVSLTEERNAVLVPAPGS 1126
              |::.||.||...:       .::.|:....:|:.|.:.                 ..|.|
Human  1297 --TIIHEKGSELHWK-------DVRELVVGRIRNKPEVDE-----------------AAVDA--- 1332

  Fly  1127 GIPGAPASWEPPSGMEPHVPVLFLNLNGDDLSAQNTNDELSVAGINSILSKEH--GHKFYTLQIL 1189
                                :|.||:    :||:             .|...|  ...||..:
Human  1333 --------------------ILSLNI----ISAK-------------YLKSSHNSSRTFYRFE-- 1358

  Fly  1190 QHLDKDVCCVASWDSSMHDSQALNRVTEANERVYLILRTTVRLSH---PAPMDLVLRKRLSINIK 1251
                      |.||||:|:|..|||||...|::|:.|...:.|.|   ||    |:.|.:.:
Human  1359 ----------AVWDSSLHNSLLLNRVTPYGEKIYMTLSAYLELDHCIQPA----VITKDVCM--- 1406

  Fly  1252 KGQTLTDRLKKFRLVRGENAIWQSGVTYEVVSNIPKASEELEDRESLAQLAASGD---------- 1306
               ....|..|....|...:::.||.:....||......||    ||.:::.:|.
Human  1407 ---VFYSRDAKISPPRSLRSLFGSGYSKSPDSNRVTGIYEL----SLCKMSDTGSPGMQRRRRKI 1464

  Fly  1307 -DCSASDGETYIEKYTRGVSAVESILTLDRLRQNVAVKELETAHGQPLSMRKTVSVPNFSQIMRF 1370
             |.|.:        |.||    |..|...|.|.:..:.|    |...|.
Human  1465 LDTSVA--------YVRG----EENLAGWRPRGDSLILE----HQWELE---------------- 1497

  Fly  1371 DASMESLLNVGRSESFADLNNSALGNKFTPAGHSPAGAGGVIRSRHSFGGKGSSDD-SPGKAFGI 1434
              .:|.|..|.::..|. |....||:...                     |..||. ||..:.|.
Human  1498 --KLELLHEVEKTRHFL-LLRERLGDSIP---------------------KSLSDSLSPSLSSGT 1538

  Fly  1435 ASPATSKLLGMRMTTLHEEPLGGHRSLDEEPEDSYSDSEY-AAEYEQERQQNKSMATRSRLTASK 1498
            .|.:|| :.....||..|..:        .|.:|   |.| :.:.|....:.|.:||:.....:.
Human  1539 LSTSTS-ISSQISTTTFESAI--------TPSES---SGYDSGDIESLVDREKELATKCLQLLTH 1591

  Fly  1499 TMD-SFMDVSSHSNQSYLSYTSSANANMKHLTGLATLSMSSSTSSGYGSQAVSCNNLSNEDIASM 1562
            |.: .|..|          :.|.::..:..::.:......||.||...:.:.:|.:|     ...
Human  1592 TFNREFSQV----------HGSVSDCKLSDISPIGRDPSESSFSSATLTPSSTCPSL-----VDS 1641

  Fly  1563 RSMSIDE-TPDFD-RVNSNSPPNRQARV--------------NPFLKDMPKAKIQE-QPEQQAKK 1610
            ||.|:|: ||:.: |.:|..|...|.::              |.||..:|  .|:| :|.....|
Human  1642 RSNSLDQKTPEANSRASSPCPEFEQFQIVPAVETPYLARAGKNEFLNLVP--DIEEIRPSSVVSK 1704

  Fly  1611 LQEAFTHPLEQLESS 1625
              :.:.|..|.|.|:
Human  1705 --KGYLHFKEPLYSN 1717

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	221/361 (61%)
		Kinesin_assoc	356..468	CDD:465047	54/194 (28%)
		FHA_KIF13	446..547	CDD:438758	39/105 (37%)
		KIF1B	741..786	CDD:463574	18/129 (14%)
		DUF3694	989..1243	CDD:463599	51/258 (20%)
		CAP_GLY	1785..1850	CDD:460154
KIF1B	NP_001352880.1	KISc_KIF1A_KIF1B	4..361	CDD:276816	221/361 (61%)
		Interaction with KIFBP. /evidence=ECO:0000269|PubMed:16225668	270..350		54/79 (68%)
		Kinesin_assoc	358..555	CDD:465047	56/196 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	431..450		3/18 (17%)
		FHA_KIF1B	530..639	CDD:438779	40/108 (37%)
		GimC	662..>719	CDD:440992	15/72 (21%)
		KIF1B	845..892	CDD:463574	11/46 (24%)
		KIF1B	<956..975	CDD:463574	5/18 (28%)
		DUF3694	1266..1413	CDD:463599	53/276 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1550..1570		7/30 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1617..1660		13/47 (28%)
		PH_KIFIA_KIFIB	1697..1799	CDD:269939	6/23 (26%)