DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Khc-73 and klp-12

DIOPT Version :9

Sequence 1:NP_001261000.1 Gene:Khc-73 / 36718 FlyBaseID:FBgn0019968 Length:1957 Species:Drosophila melanogaster
Sequence 2:NP_001023349.1 Gene:klp-12 / 178057 WormBaseID:WBGene00002223 Length:1605 Species:Caenorhabditis elegans


Alignment Length:2033 Identity:437/2033 - (21%)
Similarity:739/2033 - (36%) Gaps:627/2033 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MASDKIKVAVRVRP-FNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYSLN 64
            ||...::||:|:|| .||.::|....|       .::|.|.|   ::.....::|.:||.|    
 Worm     1 MADTCVQVALRIRPQGNREKLEGSRVC-------TSVLPNDP---QVTIGGDRSFTYDHVF---- 51

  Fly    65 PEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGT---------QESKGII 120
               :....|..|::.....::|..|.||||.:.|||||||||::| |||         :|..|:|
 Worm    52 ---DMPTLQYVVYESCVEKLVDGLFDGYNATVLAYGQTGSGKTHT-MGTAFDAAVTQKEEDLGVI 112

  Fly   121 PRLCDQLFSAIA-------NKSTPELMYKVEVSYMEIYNEKVHDLL-DPKPNKQSLKVREHNVMG 177
            ||.....|..||       .:...|..::|.|.::|:||:.|.||| |.:....|:::.|.:...
 Worm   113 PRAIQHTFRKIAECKAQAIEQGLLEPAFEVSVQFVELYNDDVLDLLSDDRSMSSSIRIHEDSRGE 177

  Fly   178 PYVDGLSQLAVTSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQ------ILTDQAT 236
            ..:.|:.|.:|.......:::..|..:|||||||||.:||||||:|::.|.|      .|.:...
 Worm   178 IVLHGVEQRSVFDMHGTMDILKNGALNRTVAATNMNEQSSRSHAIFTLHLKQQRVAANPLDESGE 242

  Fly   237 GVSGE-----KVSRMSLVDLAGSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKS 296
            ..:||     ..::...||||||||..:|||.|||.|||.:||..|..||.||:.|.. :|||.|
 Worm   243 QKTGELEMEMLCAKFHFVDLAGSERMKRTGATGDRAKEGISINVGLLALGNVIAALGG-ANGKVS 306

  Fly   297 GNDKFVPYRDSVLTWLLKDNLGGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNED 361
                .||||||.||.||:|:|||||||:|:|..|||..::.|||:|::||:|||.|.|..|.|:|
 Worm   307 ----HVPYRDSKLTRLLQDSLGGNSRTLMIACCSPSDSDFVETLNTMKYANRAKEIKNKVVANQD 367

  Fly   362 PNARIIRELRHEVETLRS-MLKHATGSPVGD------VQDKLAESENL----------MKQISQT 409
            .::::|.|||..:..|.: :|:...|....|      |.|:..|:..|          :|.:::|
 Worm   368 KSSKMIGELRSRIAALEAELLEFKQGRRTVDVDGHEVVNDQYHENVYLTSEVNHLRFRVKALNET 432

  Fly   410 WEEKLVKTERIQNERQQALEKM---------GISVQASGIKVEKNKYYLVNLNADPSLNELLVYY 465
            .:  :::||.|..:.:|....:         |...:...|:....||          |.||    
 Worm   433 LD--ILRTENIDLKAKQEFNSIASLPTAGSGGAEGEVDAIQSTFRKY----------LEEL---- 481

  Fly   466 LKDRT---LIGGRTISGQ--QPDIQLSGLGIQPEHCVITIEDSGLYMEPVQGARCFVNGSAAVE- 524
              :||   |...::...|  :.:.:...||..        ..||       |.....|....:| 
 Worm   482 --ERTKSLLYESQSTCDQLRKDNARWKALGAS--------RGSG-------GGNAEFNSQKLIEM 529

  Fly   525 -KTPLQNGDRILWGNHHFFRVN----SPKSNNTSMCASEPQTPAQLIDYNFARDEIMQNELSNDP 584
             |..::...:::..      ||    :..|..:||...|..|.      |.|.:.:.:.:|..|.
 Worm   530 AKQEVEKQRKLMES------VNIGGENVSSEYSSMAQDEDGTS------NEAEELLDEEDLDEDE 582

  Fly   585 IQTAIARLERQHEEDKQVALEK-------------QRQEYERQFQQLRNILSPSTPYAPYAPYDP 636
            .:||..:.|::..|..|:.|.:             |.:..|||.||:|......           
 Worm   583 DETAEEKQEQEESEALQIDLSEVMIELDIKEKLIDQLERAERQNQQIRETYEKK----------- 636

  Fly   637 LRMGKITPNTPTSQMRVEKWAQERDEMFRRSLGQLKTDIMRANSLVQEANFLAEEMEKKTKFSVT 701
            ||         ....|::....|||.:.... |:...:..:..::.||......::.|:.|    
 Worm   637 LR---------ELMERIKDTETERDRVLNEG-GKRGGNNEQMKAIKQEYELKITDLRKELK---- 687

  Fly   702 LQIPPANLSPNRRRGAFVSEPAILVKRTNSGSQIWTMEKLENKLIDMREMYQEHKERVLNGLDED 766
                        :..|...|...::.:  |..::....:|:::::|:::.    |..::..::||
 Worm   688 ------------KIEALDKEHLKVIAK--SQRELQEKTRLKSEVVDLKKA----KVELIKKMNED 734

  Fly   767 NAKPQDPFYESQENHNLIGVANIFLEVLFHDVKLDYHTPIISQQGEVAGRLQVEIERIAGQMPQD 831
            ..|     .::|:..|....|.                      .|...|||....|        
 Worm   735 KKK-----QKTQQLANARAFAT----------------------KEKQTRLQANKIR-------- 764

  Fly   832 RMCESVSESSGDSRDEYDDPVDPTSNQITCRVTIKCASGLPLSLSNFVFCQYTFWGHQEMVVPVI 896
                 ..|.....|:::   :..|:.::......|..:......:|        .|.......|.
 Worm   765 -----TLEMKDKQREQF---LKKTTQEVNALRKEKAVAAATARQAN--------RGTPRGGAAVT 813

  Fly   897 NAESTAHDQNMVFKFEHTQDFTVTINEEFLEHCIEGALSIEVWGHRSAGFSKTKGWEV----EQQ 957
            |:.:..                       :...:.|..:|:.... ||..||.| |:|    .::
 Worm   814 NSPARR-----------------------VRGVVGGVQAIKELAF-SAKASKVK-WDVIVRKIEE 853

  Fly   958 QAKARSLVDRW-AELSRKIE----LWVEIHELNDNGEYSPVEVTNRNEVLTG--GIYQLRQGQQR 1015
            .|:.|.:|.:. |||.|.:.    :.|||.| |:.......:|..|:.:|..  ...|..|..|.
 Worm   854 SARRRQIVQKMEAELERYLNERHAVMVEIVE-NEKQFTQSQDVIYRDGLLEAIDSAKQKLQYVQD 917

  Fly  1016 RVNVRVKPVQNSGTLPIIC-------------QSIVNVAIGSVTVRSRLQRPLDSYQEE------ 1061
            ::..:.|         :||             :.|::|.:...|:: :|....|:..|.      
 Worm   918 QITYQQK---------LICDVDEDITASNAENEPILDVGLKKQTIK-QLFDGCDTLSEARYLLQH 972

  Fly  1062 --DLTVLREKWSEALGRRRQYLDQQIQMLIKKEEKNEQERERELSLVHQWV-SLTEERNAVLVPA 1123
              ||.:           .:..|..:::...|:.....::.|::.||..|.: |:.|::|.|    
 Worm   973 LFDLCI-----------DKAALAAKVESEFKECAARIEQLEQQSSLKEQLLTSIIEDKNLV---- 1022

  Fly  1124 PGSGIPGAPASWEPPSGMEPHVPVLFLNLNGDDLSAQNTNDELSVAGINSILSKEHGHKFYTLQI 1188
                           ..:|..||        .||....|:.:.|:....|....|..|.....::
 Worm  1023 ---------------DEIEGFVP--------SDLRKSRTSSQSSLLRSGSPSVVEDAHTLQNYKV 1064

  Fly  1189 LQH--LDKDVCCVASWDSSMHDSQALNRVTEANERVYLILRTTVRLSHPAPMDLVLRKRLSINIK 1251
            .:|  ..:::....|.::||        |::||             ::|                
 Worm  1065 RRHTATQEELLFANSEENSM--------VSDAN-------------ANP---------------- 1092

  Fly  1252 KGQTLTDRLKKFRLVRGENAIWQSGVTYEVVSNIPKASEELEDRESLAQLAASGDDCSASDGETY 1316
                                      |.:|.:::..:.|..|.::.:|.::.|....|.::..:.
 Worm  1093 --------------------------TVDVGADVGDSDERKEKKKRIAFVSTSPASTSFANSTSQ 1131

  Fly  1317 IEKYTRGV---SAVESILTLDRLRQNVAVKELETAHGQPLSMRKTVS-VPNFSQIMRFDASMESL 1377
            ...::|..   |.|..:...:.:|:  :|:.|....|...:.||.:| :|:.::........:|.
 Worm  1132 SPSFSRNTRFRSTVGGVSNNNNIRK--SVQPLINGKGVSSTARKGISRLPSVTEDPEIGIFAKSF 1194

  Fly  1378 LNVGRSESFADLNNSALGNKFTPAGHSPAGAGGVIRSRHSFGGKGSSDDSPGKA-FGIASPA--- 1438
              .|||.|  :|.:|:.....|           .:.|.:....:|::..|..|: |...||:   
 Worm  1195 --PGRSRS--NLMSSSSSTTTT-----------TLSSSNLLNPRGTTSSSSSKSVFARISPSWLS 1244

  Fly  1439 --------------TSKLL----GMR---MTTLHEEPLGGHR----SLDEEPEDSYSDSEYAAEY 1478
                          .|:::    |||   :|..|  .|.||.    |:|                
 Worm  1245 DTCAELIMRNNNRKQSRIVPVKDGMRGNVITRTH--TLEGHARGVLSVD---------------- 1291

  Fly  1479 EQERQQNKSMATRSRLTASKTMD-----SFMDVSSHSNQSYL-SYTSSANANMKHLTGLATLSMS 1537
                ...|.|.|.|:...:|..|     ....:..|.|..:| .:...:|.       :.|.||.
 Worm  1292 ----VNEKLMVTGSKDRTAKLWDIEACREIRTLGIHPNNVHLVKFVPFSNY-------VFTFSMF 1345

  Fly  1538 SSTSSGYGSQAVSCNNLSNEDIASMRSMSIDETPDFDRVNSNSPPNRQARVNPFLKDMPKAKIQE 1602
            .:.:..|.:....|..:.|.........|||.:....|.|:          .|||:.:..|    
 Worm  1346 EARAWDYRTPECICVKVLNSSGQVNEGDSIDVSQVMPRQNT----------IPFLETLITA---- 1396

  Fly  1603 QPEQQAKKLQEAFTHPLEQLESSQNAQSDDDECAQLPKNNNN------NLDLVNEPKPLSSQTDL 1661
                                       :|.|...||...:.:      ||   .|.|||..   |
 Worm  1397 ---------------------------ADVDPTGQLLFTSFSAYVRVWNL---REWKPLGR---L 1428

  Fly  1662 EESMSQPKS-----KTEFATDNQ----NGNRSSDELSHSSEDLLEGDGIVRE-ELPAGKVVRRKK 1716
            ..:...|||     :|....:..    .|:|               |..|:| |:..|..|...|
 Worm  1429 NAASHSPKSEVSCLRTTMTPEGSILAYTGSR---------------DHYVKEYEVGLGTGVIESK 1478

  Fly  1717 SNTQPPSNGNSINNNNNGTTQAPRINHRASVAKMEGLAAYLDSSIMTSSTEVDEESKDVELVLPE 1781
            ....||       :.:|.|...|...|..:.:|        |.:||..|.: |.:.:.:||...:
 Worm  1479 CEFTPP-------HYDNVTAVLPLNGHLYTASK--------DVNIMKFSLK-DGKREHLELRAHQ 1527

  Fly  1782 WIV--------VGESVLIRPYNTSGVIRF--VGTT-------EFQPGAWIGVELDTPTGKNDGSV 1829
            ..:        .|:.:|:.... .|.|||  ||::       |:......|:        ||   
 Worm  1528 QYIQSLTGFGPKGKELLVSACK-DGTIRFWDVGSSSRMKLVEEYSKAHQEGI--------ND--- 1580

  Fly  1830 KGVQYFQCKPKHGMFVRS 1847
                  .|..|..:|..|
 Worm  1581 ------MCSTKSMLFTAS 1592

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Khc-73NP_001261000.1 KISc_KIF1A_KIF1B 4..359 CDD:276816 147/383 (38%)
KISc 6..359 CDD:214526 147/381 (39%)
Kinesin_assoc 356..468 CDD:292801 28/137 (20%)
FHA 446..546 CDD:238017 19/110 (17%)
KIF1B 741..786 CDD:289208 8/44 (18%)
DUF3694 <1196..1252 CDD:289256 7/55 (13%)
CAP_GLY 1786..1850 CDD:279625 16/71 (23%)
klp-12NP_001023349.1 KISc_KIF4 4..359 CDD:276823 144/377 (38%)
KISc 6..365 CDD:214526 147/381 (39%)
ATP-synt_B <609..739 CDD:304375 27/177 (15%)
WD40 1277..1601 CDD:238121 85/441 (19%)
WD40 <1287..1603 CDD:225201 81/429 (19%)
WD40 repeat 1288..1322 CDD:293791 8/53 (15%)
WD40 repeat 1327..1364 CDD:293791 7/43 (16%)
WD40 repeat 1373..1429 CDD:293791 19/102 (19%)
WD40 repeat 1439..1482 CDD:293791 10/57 (18%)
WD40 repeat 1489..1524 CDD:293791 10/43 (23%)
WD40 repeat 1531..1556 CDD:293791 5/25 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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