DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Khc-73 and klp-15

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	NP_491633.1	Gene:	klp-15 / 172213	WormBaseID:	WBGene00002225	Length:	587	Species:	Caenorhabditis elegans

Alignment Length:	350	Identity:	120/350 - (34%)
Similarity:	185/350 - (52%)	Gaps:	37/350 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPK-TFAFDHCFYSLNPEDE 68
            :|:|||||||..:.|.:..:..| |.....||..|       |..:|. ...|:..|..:..:.|
Worm   248 QIRVAVRVRPLIKSEADASSSAI-EYPAIDTIRIN-------EGSKPGIVVKFEKVFTPVFSQKE 304

  Fly    69 NFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMM-GTQESKGIIPRLCDQLFSAIA 132
            .||:.|.        .:.::..|||..:.|||||||||::||. |..|.:|||||....||:...
Worm   305 VFANVEE--------FIRSSLHGYNVGLIAYGQTGSGKTHTMRGGNGEEEGIIPRAAAFLFAESR 361

  Fly   133 NKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQDIDNL 197
            ...:....:...:|::|:||...:|||..:...| |::.:..|.   :.|||:..:::..|:..|
Worm   362 KLESLGWKFDFSLSFLEVYNNVAYDLLSDRAVVQ-LRLNDQTVS---MIGLSEHTISNVSDVARL 422

  Fly   198 MTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQ-ATGVSGEKVSRMSLVDLAGSERAVKTG 261
            :...:..|..|||..|..|||||||:   :.:|...| :||:|..  .::.||||||||||.::|
Worm   423 LRVADGGRKTAATKCNESSSRSHAVY---MWKITAHQPSTGISTS--CQLKLVDLAGSERAKESG 482

  Fly   262 AVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLG-GNSRTVM 325
            ..||:.||.:|||:||:.|.:.||:...|..        .|.||||.||.:|.|.|| |||:|::
Worm   483 VSGDQFKEMTNINQSLSILQMCISQQRSQKG--------HVSYRDSKLTQVLMDCLGRGNSKTMV 539

  Fly   326 VATISPSADNYEETLSTLRYADRAK 350
            |..::|..:...|:..::.:|.:.:
Worm   540 VVNLNPCNEQATESKRSIEFASKMR 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	120/349 (34%)
		KISc	6..359	CDD:214526	120/348 (34%)
		Kinesin_assoc	356..468	CDD:292801
		FHA	446..546	CDD:238017
		KIF1B	741..786	CDD:289208
		DUF3694	<1196..1252	CDD:289256
		CAP_GLY	1786..1850	CDD:279625
klp-15	NP_491633.1	PHA03378	<27..153	CDD:223065
		Tropomyosin_1	<147..242	CDD:372267
		ABC_tran_CTD	147..193	CDD:379824
		KISc	248..564	CDD:276812	120/348 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910