Protein Alignment Khc-73 and Kif3a

DIOPT Version :10

• Sequence 1: NP_001261000.1
• Gene: Khc-73 / 36718
• FlyBaseID: FBgn0019968
• Length: 1957
• Species: Drosophila melanogaster
• Sequence 2: XP_006532388.1
• Gene: Kif3a / 16568
• MGIID: 107689
• Length: 725
• Species: Mus musculus
• Alignment Length: 818
• Identity: 242/818 - (29%)
• Similarity: 355/818 - (43%)
• Gaps: 237/818 - (28%)

  Fly     4 DKIKVAVRVRPFNRREIELDTKCIVEMEK-------QQTILQNPPPLEKIERKQPKTFAFDHCFY 61
            |.:||.||.||.|.||..:..:..|.:::       .:|...|.|         ||||.||..|
Mouse    13 DNVKVVVRCRPLNEREKSMCYRQAVSVDEMRGTITVHKTDSSNEP---------PKTFTFDTVF- 67

  Fly    62 SLNPEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQE---SKGIIPRL 123
              .||    :.|..|::...|.|:|:..:|||..||||||||:||::||.|.:.   .:|:||..
Mouse    68 --GPE----SKQLDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAVPGLRGVIPNS 126

  Fly   124 CDQLFSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAV 188
            ...:|..|| |:..:..:.|.|||:|||||:|.|||. |...|.|:|:|...:|.|:..||...|
Mouse   127 FAHIFGHIA-KAEGDTRFLVRVSYLEIYNEEVRDLLG-KDQTQRLEVKERPDVGVYIKDLSAYVV 189

  Fly   189 TSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGE---KVSRMSLVD 250
            .:..|:|.:||.|:|:|:|.|||||..||||||:|::.    :.....||.|.   ::.::.|||
Mouse   190 NNADDMDRIMTLGHKNRSVGATNMNEHSSRSHAIFTIT----IECSEKGVDGNMHVRMGKLHLVD 250

  Fly   251 LAGSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKD 315
            ||||||..||||.|.||||.:.||.||:|||.|||.|.|       |....||||:|.||.||:|
Mouse   251 LAGSERQAKTGATGQRLKEATKINLSLSTLGNVISALVD-------GKSTHVPYRNSKLTRLLQD 308

  Fly   316 NLGGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSM 380
            :|||||:|:|.|.|.|:..||:||:||||||:|||.|.|.|.:||||...::|:.:.|:|.|:.
Mouse   309 SLGGNSKTMMCANIGPADYNYDETISTLRYANRAKNIKNKARINEDPKDALLRQFQKEIEELKK- 372

  Fly   381 LKHATGSPVGDVQDKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQASGIKVEKN 445
                          ||.|.|.
Mouse   373 --------------KLEEGEE-------------------------------------------- 379

  Fly   446 KYYLVNLNADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVITIEDSGLYMEPV 510
                                      :.|..|||.:.|.:...||          ||.
Mouse   380 --------------------------VSGSDISGSEEDDEEGELG----------EDG------- 401

  Fly   511 QGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNTSMCA--SEPQ---TPAQLIDYNF 570
                         ||...:.|             :|..|::.|.|:  .:|.   .|.|......
Mouse   402 -------------EKKKKRRG-------------SSSSSSSDSTCSVIEKPLDEFLPHQAGKKKV 440

  Fly   571 ARDEIMQNELSNDPIQTAI-ARLERQHEEDKQVALEKQRQE-----YERQFQQLRNILSPSTPYA 629
            :.|::::.:...|..:.|: .:|:.:.||..:...|.:|:|     .:::.|.|...||......
Mouse   441 SPDKMVEMQAKIDEERKALETKLDMEEEERNKARAELERREKDLLKAQQEHQSLLEKLSALEKKV 505

  Fly   630 PYAPYDPLRMGKITPNTPTSQMRVEKWAQERDEMFRRSLGQLKTDIMRANSLVQEANFLAEEMEK 694
            .....|.|..                 |:|::::...|..:|:....||..       |.:|:|:
Mouse   506 IVGGVDLLAK-----------------AEEQEKLLEESNMELEERRRRAEQ-------LRKELEE 546

  Fly   695 KTKFSVTLQIPPANLSPNRRRGAFVSEPAILVKRTNSGSQIWTMEKLENKLIDMREMYQEHKERV 759
            |.:..:.::....:|....:            .:|....::|||  |.....:|.::.||| :|.
Mouse   547 KEQERLDIEEKYTSLQEEAQ------------GKTKKLKKVWTM--LMAAKSEMADLQQEH-QRE 596

  Fly   760 LNGLDE----------------DNAKPQDPFYESQENH 781
            :.||.|                ||..||| :.|..||:
Mouse   597 IEGLLENIRQLSRELRLQMLIIDNFIPQD-YQEMIENY 633

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	164/367 (45%)
		Kinesin_assoc	356..468	CDD:465047	13/111 (12%)
		FHA_KIF13	446..547	CDD:438758	12/100 (12%)
		KIF1B	741..786	CDD:463574	17/57 (30%)
		DUF3694	989..1243	CDD:463599
		CAP_GLY	1785..1850	CDD:460154
Kif3a	XP_006532388.1	KISc_KIF3	13..345	CDD:276822	161/360 (45%)
		Smc	<450..>614	CDD:440809	38/202 (19%)