Protein Alignment Khc-73 and Kif1c

DIOPT Version :10

• Sequence 1: NP_001261000.1
• Gene: Khc-73 / 36718
• FlyBaseID: FBgn0019968
• Length: 1957
• Species: Drosophila melanogaster
• Sequence 2: NP_665884.2
• Gene: Kif1c / 113886
• RGDID: 70928
• Length: 1100
• Species: Rattus norvegicus
• Alignment Length: 1291
• Identity: 424/1291 - (32%)
• Similarity: 585/1291 - (45%)
• Gaps: 409/1291 - (31%)

  Fly     1 MASDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYS-LN 64
            ||...:||||||||||.||...|.||:|.|:...|.:.||    |..:..||:|.||:.::| .:
  Rat     1 MAGASVKVAVRVRPFNARETSQDAKCVVSMQGNTTSIINP----KQSKDAPKSFTFDYSYWSHTS 61

  Fly    65 PEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQE--SKGIIPRLCDQL 127
            .||..||||:.|:..:|..:|.:||:|||.|||||||||:||||||||.||  .:||:|:||:.|
  Rat    62 VEDPQFASQQQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGRQEPGQQGIVPQLCEDL 126

  Fly   128 FSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQ 192
            ||.:....:.:|.|.|||||||||.|:|.|||:|| ::.||:||||.::||||..||:||||||.
  Rat   127 FSRVNVNQSAQLSYSVEVSYMEIYCERVRDLLNPK-SRGSLRVREHPILGPYVQDLSKLAVTSYA 190

  Fly   193 DIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSERA 257
            ||.:||..|||:|||||||||..||||||||::|.||...||.||:..||||::|||||||||||
  Rat   191 DIADLMDCGNKARTVAATNMNETSSRSHAVFTIVFTQRSHDQLTGLDSEKVSKISLVDLAGSERA 255

  Fly   258 VKTGAVGDRLKEGSNINKSLTTLGLVISKLAD-QSNGKKSGNDKFVPYRDSVLTWLLKDNLGGNS 321
            ..:||.|.|||||:||||||||||.|||.||| ||..:||   .|:||||||||||||:||||||
  Rat   256 DSSGARGMRLKEGANINKSLTTLGKVISALADLQSKKRKS---DFIPYRDSVLTWLLKENLGGNS 317

  Fly   322 RTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSM------ 380
            ||.|:|.:||:..||||||||||||||.|:|..:||:|||||||:||||:.||..||.:
  Rat   318 RTAMIAALSPADINYEETLSTLRYADRTKQIRCNAVINEDPNARLIRELQEEVARLRELLMAQGL 382

  Fly   381 -------LKHATGSPVG---------------------------------------DVQDKLAES 399
                   ||...|||.|                                       :..::|.|:
  Rat   383 SASALGGLKVEEGSPGGVLPAASSPPAPASPSSPPPHNGELEPSFSPSAEPQIGPEEAMERLQET 447

  Fly   400 ENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQASGIKV----EKNKYYLVNLNADPSLNE 460
            |.::.::::||||||.|||.::.||:..|.:||::|:..|..|    .|...:|||||.||.::|
  Rat   448 EKIIAELNETWEEKLRKTEALRMEREALLAEMGVAVREDGGTVGVFSPKKTPHLVNLNEDPLMSE 512

  Fly   461 LLVYYLKDRTLIGGRTISGQ-QPDIQLSGLGIQPEHCVITI--EDSG---LYMEPVQGARCFVNG 519
            .|:|::||     |.|..|| ..||:|:|..|:.:||:...  :..|   :.:||.:||..:|||
  Rat   513 CLLYHIKD-----GVTRVGQVDVDIKLTGQFIREQHCLFRSIPQPDGEVMVTLEPCEGAETYVNG 572

  Fly   520 SAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNTSM---CASEPQTPAQLIDYNFARDEIMQNELS 581
            ....|...|::|:||:.|.:|.||.|.|:......   ....|..|::.:|:|||:.|:::
  Rat   573 KLVTEPLVLKSGNRIVMGKNHVFRFNHPEQARLERERGVPPPPGPPSEPVDWNFAQKELLE---- 633

  Fly   582 NDPIQTAIARLERQHEEDKQVALEKQRQEYERQFQQLRNILSPSTPYAPYAPYDPLRMGKITPNT 646
                         |...|.::.:||:.|:.|.|::
  Rat   634 -------------QQGIDIKLEMEKRLQDLENQYR------------------------------ 655

  Fly   647 PTSQMRVEKWAQERDEMFRRSLGQLKTDIMRANSLVQEANFLA-----EEMEKKT-------KFS 699
                       :|::|               |:.|:::....|     |:.:|::       ..|
  Rat   656 -----------KEKEE---------------ADLLLEQQRLYADSDSGEDSDKRSCEESWRLISS 694

  Fly   700 VTLQIPPANLSPNRRRGAFVSEPAILVKRTNSGSQIWTMEKLENKLIDMREMYQEHKERVLNGLD 764
            :..|:||..:.             .:|||....|        ..|....|.:||..:.|.|.|
  Rat   695 LREQLPPNTVQ-------------TIVKRCGLPS--------SGKRRAPRRVYQIPQRRRLQG-- 736

  Fly   765 EDNAKPQDPFYESQENHNLIGVANIFLEVLFHDVKLDYHTPIISQQGEVAGRLQVEIERIAGQMP 829
                  :||.:.:..:..:..|..|..||...|.:   |           ||  .|||.:|. :.
  Rat   737 ------KDPRWATMADLKMQAVKEICYEVALADFR---H-----------GR--AEIEALAA-LK 778

  Fly   830 QDRMCESVS--ESSGD-----SRDEYDDPVDPTSNQITCRVTIKCASGLPLSLSNFVFCQYTFWG 887
            ...:|.:..  |..||     :||.:|
  Rat   779 MRELCRTYGKPEGPGDAWRAVARDVWD-------------------------------------- 805

  Fly   888 HQEMVVPVINAESTAHDQNMVFKFEHTQDFTVTINEEFLEHC-------IEGALSIEVWGHRSAG 945
                                            |:.||  |.|       .|||...||...| |.
  Rat   806 --------------------------------TVGEE--EGCGGGGGGGEEGARGAEVEDLR-AH 835

  Fly   946 FSKTKG--WEVEQQQA----KARSLVDRWAELSRKIELWVEIHELNDNGE-----YSPVEVTNRN 999
            ..|..|  .||:.|.:    :.::|.||...:.|.|.|..::.:  ||.|     ::|.|
  Rat   836 IDKLTGILQEVKLQNSSKDRELQALRDRMLRMERVIPLTQDLED--DNEESGLVTWAPPE----- 893

  Fly  1000 EVLTGGIYQLRQGQQRRVNVRVKPVQNSGTLPIICQSIVNVAIGSVTVRSRLQRPLDSYQEEDLT 1064
                 |...:.:......:..|:|                    |...:|..:| :....|||..
  Rat   894 -----GSEAVEEAVSNDHSPAVRP--------------------SSPPQSSWER-VSRLMEEDPA 932

  Fly  1065 VLREKWSEALGRRRQYLDQQIQM---------------------------LIKKEEKNEQERERE 1102
            ..|       ||.|....:|:::                           |....:.|.|.||
  Rat   933 FRR-------GRLRWLKQEQLRLQGLQGSGGRGGGLRRPPARFVPPHDCKLRFPFKSNPQHRE-- 988

  Fly  1103 LSLVHQWVSLTEERNAVLVPAPGSG------------IPGAPASWEPPSGMEPHVP 1146
                 .|            |..|||            .|..|.:..|||...||.|
  Rat   989 -----SW------------PGMGSGEAPGPQPPEEVTAPPPPPNRRPPSPRRPHRP 1027

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	221/358 (62%)
		Kinesin_assoc	356..468	CDD:465047	54/167 (32%)
		FHA_KIF13	446..547	CDD:438758	41/106 (39%)
		KIF1B	741..786	CDD:463574	9/44 (20%)
		DUF3694	989..1243	CDD:463599	35/202 (17%)
		CAP_GLY	1785..1850	CDD:460154
Kif1c	NP_665884.2	KISc_KIF1A_KIF1B	4..355	CDD:276816	221/358 (62%)
		Kinesin_assoc	352..522	CDD:465047	56/174 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	398..435		1/36 (3%)
		FHA_KIF1C	498..599	CDD:438780	40/105 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	900..924		5/44 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	949..1100		18/98 (18%)