Protein Alignment Khc-73 and KIF3A

DIOPT Version :10

• Sequence 1: NP_001261000.1
• Gene: Khc-73 / 36718
• FlyBaseID: FBgn0019968
• Length: 1957
• Species: Drosophila melanogaster
• Sequence 2: NP_001287720.1
• Gene: KIF3A / 11127
• HGNCID: 6319
• Length: 726
• Species: Homo sapiens
• Alignment Length: 815
• Identity: 238/815 - (29%)
• Similarity: 358/815 - (43%)
• Gaps: 230/815 - (28%)

  Fly     4 DKIKVAVRVRPFNRREIELDTKCIVEMEK-------QQTILQNPPPLEKIERKQPKTFAFDHCFY 61
            |.:||.||.||.|.||..:..|..|.:::       .:|...|.|         ||||.||..|
Human    13 DNVKVVVRCRPLNEREKSMCYKQAVSVDEMRGTITVHKTDSSNEP---------PKTFTFDTVF- 67

  Fly    62 SLNPEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQ---ESKGIIPRL 123
              .||    :.|..|::...|.|:|:..:|||..||||||||:||::||.|.:   |.:||||..
Human    68 --GPE----SKQLDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAIPELRGIIPNS 126

  Fly   124 CDQLFSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAV 188
            ...:|..|| |:..:..:.|.|||:|||||:|.|||. |...|.|:|:|...:|.|:..||...|
Human   127 FAHIFGHIA-KAEGDTRFLVRVSYLEIYNEEVRDLLG-KDQTQRLEVKERPDVGVYIKDLSAYVV 189

  Fly   189 TSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGE---KVSRMSLVD 250
            .:..|:|.:||.|:|:|:|.|||||..||||||:|::.    :.....|:.|.   ::.::.|||
Human   190 NNADDMDRIMTLGHKNRSVGATNMNEHSSRSHAIFTIT----IECSEKGIDGNMHVRMGKLHLVD 250

  Fly   251 LAGSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKD 315
            ||||||..||||.|.||||.:.||.||:|||.|||.|.|       |....||||:|.||.||:|
Human   251 LAGSERQAKTGATGQRLKEATKINLSLSTLGNVISALVD-------GKSTHVPYRNSKLTRLLQD 308

  Fly   316 NLGGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSM 380
            :|||||:|:|.|.|.|:..||:||:||||||:|||.|.|.|.:||||...::|:.:.|:|.|:.
Human   309 SLGGNSKTMMCANIGPADYNYDETISTLRYANRAKNIKNKARINEDPKDALLRQFQKEIEELKK- 372

  Fly   381 LKHATGSPVGDVQDKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQASGIKVEKN 445
                          ||.|.|.
Human   373 --------------KLEEGEE-------------------------------------------- 379

  Fly   446 KYYLVNLNADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVITIEDSGLYMEPV 510
                                      |.|..|||.:.|....|          .:.:.|
Human   380 --------------------------ISGSDISGSEEDDDEEG----------EVGEDG------ 402

  Fly   511 QGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNTSMCA--SEPQ---TPAQLIDYNF 570
                         ||...:.|             :|..|::.|.|:  .:|.   .|.|......
Human   403 -------------EKRKKRRG-------------SSSSSSSDSTCSVIEKPLDKFLPNQAGKKKV 441

  Fly   571 ARDEIMQNELSNDPIQTAI-ARLERQHEE--DKQVALEKQRQEYERQFQQLRNILSPSTPYAPYA 632
            :.|::::.:...|..:.|: .:|:.:.||  ..:..|||:.::..:..|:.:::|.
Human   442 SPDKMIEMQAKIDEERKALETKLDMEEEERNKARAELEKREKDLLKAQQEHQSLLE--------- 497

  Fly   633 PYDPLRMGKITPNTPTSQMRVEKWAQERDEMFRRSLGQLKTDIMRANSLVQEANFLAEEMEKKTK 697
                 ::..:........:.:...|:|::::...|..:|:....||..       |..|:|:|.:
Human   498 -----KLSALEKKVIVGGVDLLAKAEEQEKLLEESNMELEERRKRAEQ-------LRRELEEKEQ 550

  Fly   698 FSVTLQIPPANLSPNRRRGAFVSEPAILVKRTNSGSQIWTMEKLENKLIDMREMYQEHKERVLNG 762
            ..:.::....:|....:            .:|....::|||  |.....:|.::.||| :|.:.|
Human   551 ERLDIEEKYTSLQEEAQ------------GKTKKLKKVWTM--LMAAKSEMADLQQEH-QREIEG 600

  Fly   763 LDE----------------DNAKPQDPFYESQENH 781
            |.|                ||..|:| :.|..||:
Human   601 LLENIRQLSRELRLQMLIIDNFIPRD-YQEMIENY 634

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	166/367 (45%)
		Kinesin_assoc	356..468	CDD:465047	13/111 (12%)
		FHA_KIF13	446..547	CDD:438758	11/100 (11%)
		KIF1B	741..786	CDD:463574	16/57 (28%)
		DUF3694	989..1243	CDD:463599
		CAP_GLY	1785..1850	CDD:460154
KIF3A	NP_001287720.1	KISc_KIF3	13..345	CDD:276822	163/360 (45%)
		Smc	<451..>615	CDD:440809	34/199 (17%)