DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Khc-73 and kif28p

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	XP_031758561.1	Gene:	kif28p / 101732886	XenbaseID:	XB-GENE-22065598	Length:	913	Species:	Xenopus tropicalis

Alignment Length:	978	Identity:	325/978 - (33%)
Similarity:	474/978 - (48%)	Gaps:	188/978 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFD-----HCFYSL 63
            |.:|||||||||::||.:..:||::.|:...|.:.:|..:     ...|||.||     |..|..
Frog    42 DSVKVAVRVRPFSKREKDASSKCVISMKTNCTTICDPKNV-----GNEKTFKFDLAYWSHSEYLK 101

  Fly    64 NPED--------ENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGII 120
            |.|.        ..:|.|:|||..:|:||||||:|||||.:.|||||||||||:|:|...::|||
Frog   102 NTESTLVPDGSYSRYADQKTVFQDLGQGILDNAWQGYNATLLAYGQTGSGKSYSMIGYGTNRGII 166

  Fly   121 PRLCDQLFSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQ 185
            |.:|::||.||.|.......|:|..|.:|||||:|.|||........|||||....|.|||||..
Frog   167 PLVCEELFRAIENNQEKNKQYQVTFSMLEIYNEQVTDLLSKTKKSGGLKVREDQHQGFYVDGLKL 231

  Fly   186 LAVTSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVD 250
            :...||..|:.|:.:|.|.||.|:|:|||.|||||.|.::...|||..:..    .|.|.::|||
Frog   232 VPCESYAQIERLIEQGKKIRTTASTSMNASSSRSHMVITIQFKQILLKEDI----TKQSSINLVD 292

  Fly   251 LAGSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKD 315
            ||||||...:.:.||||:||:.:|.||||||.|||.||:.:.|||.   ..:||||||||.||:.
Frog   293 LAGSERQKSSASEGDRLREGTCVNLSLTTLGNVISALAEAAMGKKV---LHIPYRDSVLTKLLQS 354

  Fly   316 NLGGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSM 380
            .|||||||||:|.|||:...|||||||||||:|||:|.|.|::|..|..|:|:||:.|...|.|.
Frog   355 ALGGNSRTVMIAAISPADICYEETLSTLRYAERAKKIKNKAIINAGPTERLIKELKAENNKLLSR 419

  Fly   381 LKHATGSPVGDVQ-DKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQASGIKVEK 444
            |.....|  |..| ....|:|..::.:..|||.:|   :..:.|.:|         |.:.|..|:
Frog   420 LAGLGNS--GKRQLSGCYENELRIQTMQITWEHQL---QEARKEWEQ---------QYAAITQER 470

  Fly   445 NKY----YLVNLNADPSLNELLVYYLKDRTLIGGRTISGQQPD--IQLSGLGIQPEHCVITIEDS 503
            ...    ||:|:|.||.|:.:|.:::::     |.:..||.|.  |.|.||||.|:|......:|
Frog   471 RMMQLYPYLLNINEDPQLSGVLKHFIQE-----GASDVGQDPSNVITLRGLGILPQHATFINSES 530

  Fly   504 GLYMEPVQGARCFVNGSAAVEKTPLQNGDRILWG-NHHFFRVNSPKSNN-TSMCASEPQTPAQLI 566
            .::::|....:..|||...|..|.||:.|||:.| |..:..:..|.... ..:|.         .
Frog   531 KVFVKPHGKGKVIVNGVPIVLNTKLQHLDRIILGSNSAYLYIGFPAERGPDDLCR---------F 586

  Fly   567 DYNFARDEIMQNELSNDPIQTAIARLERQHEEDKQVALEKQRQEYERQFQQLRNILSPSTPYAPY 631
            ||:|.:.|:...|      ..::..|...|.::
Frog   587 DYDFFQSELAAAE------GFSVDTLGPVHNKE-------------------------------- 613

  Fly   632 APYDPLRMGKITPNTPTSQMRVEKWAQERDEMFRRSLGQLKTDIMRANSLVQEANFLAEEMEKKT 696
                    ||..|                      |:..:..|.::...||.|||.::||:.|..
Frog   614 --------GKPDP----------------------SVLAVFHDFIKLMPLVAEANQMSEELSKDL 648

  Fly   697 KFSVTLQIPPANLSPNRRRGAFVSEPAILVKRTNSGSQ---IWTMEKLENKLIDMREMYQEHKER 758
            ||.:.::    ||:....|| :..:..|.||..|..:.   ||:..|..|:...|.|:||    |
Frog   649 KFELKVK----NLALTDSRG-YDLQKEISVKVINQITNQVWIWSKSKFINRKFLMEELYQ----R 704

  Fly   759 VLNGLDEDNAKPQDPFYESQENHNLIGVANIFLEVLFHDVKLDYHTPIISQQGEVAGRLQVEIER 823
            .|:|.|....:..|||::..|..:| |.|:|:|:.|.:.:||:..|.:::.:|.....|.:.|
Frog   705 YLDGGDISLDRESDPFWDPVEVIHL-GSAHIWLQSLAYCMKLEEQTELLNSEGVEEAILVINI-- 766

  Fly   824 IAGQMPQDRMCESVSESSGDSRDEYDDPVDPTSNQITCRVTI-KCAS----------GLPLSLSN 877
                    ..|.......|: .|...||::....:|..::.| :|..          |:.:....
Frog   767 --------TPCSDTERPFGE-EDIVIDPLELLGRKIEFQIHILQCLGVRWLKEATNRGIQIGYHF 822

  Fly   878 FVFCQ--YT--FWGHQEMVVPVINAESTAHDQNMVFKFEHTQDF-TVTINEEFLEHCIEGALSIE 937
            :..||  ||  .|   :.|.|:|               :|...| .:.::...|.:..:.||.::
Frog   823 YDVCQCVYTKPVW---KNVNPII---------------DHKLQFVALNVSNVLLSYLQKHALVVD 869

  Fly   938 VWG 940
            :||
Frog   870 LWG 872

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	183/367 (50%)
		KISc	6..359	CDD:214526	182/365 (50%)
		Kinesin_assoc	356..468	CDD:292801	33/116 (28%)
		FHA	446..546	CDD:238017	34/106 (32%)
		KIF1B	741..786	CDD:289208	14/44 (32%)
		DUF3694	<1196..1252	CDD:289256
		CAP_GLY	1786..1850	CDD:279625
kif28p	XP_031758561.1	Motor_domain	42..398	CDD:419868	183/367 (50%)
		FHA	477..573	CDD:238017	34/100 (34%)
		KIF1B	691..725	CDD:403579	12/37 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010