Protein Alignment Khc-73 and kif28

DIOPT Version :10

• Sequence 1: NP_001261000.1
• Gene: Khc-73 / 36718
• FlyBaseID: FBgn0019968
• Length: 1957
• Species: Drosophila melanogaster
• Sequence 2: XP_031758561.1
• Gene: kif28 / 101732886
• XenbaseID: XB-GENE-22065598
• Length: 913
• Species: Xenopus tropicalis
• Alignment Length: 978
• Identity: 325/978 - (33%)
• Similarity: 474/978 - (48%)
• Gaps: 188/978 - (19%)

  Fly     4 DKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFD-----HCFYSL 63
            |.:|||||||||::||.:..:||::.|:...|.:.:|..:     ...|||.||     |..|..
 Frog    42 DSVKVAVRVRPFSKREKDASSKCVISMKTNCTTICDPKNV-----GNEKTFKFDLAYWSHSEYLK 101

  Fly    64 NPED--------ENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGII 120
            |.|.        ..:|.|:|||..:|:||||||:|||||.:.|||||||||||:|:|...::|||
 Frog   102 NTESTLVPDGSYSRYADQKTVFQDLGQGILDNAWQGYNATLLAYGQTGSGKSYSMIGYGTNRGII 166

  Fly   121 PRLCDQLFSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQ 185
            |.:|::||.||.|.......|:|..|.:|||||:|.|||........|||||....|.|||||..
 Frog   167 PLVCEELFRAIENNQEKNKQYQVTFSMLEIYNEQVTDLLSKTKKSGGLKVREDQHQGFYVDGLKL 231

  Fly   186 LAVTSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVD 250
            :...||..|:.|:.:|.|.||.|:|:|||.|||||.|.::...|||..:..    .|.|.::|||
 Frog   232 VPCESYAQIERLIEQGKKIRTTASTSMNASSSRSHMVITIQFKQILLKEDI----TKQSSINLVD 292

  Fly   251 LAGSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKD 315
            ||||||...:.:.||||:||:.:|.||||||.|||.||:.:.|||.   ..:||||||||.||:.
 Frog   293 LAGSERQKSSASEGDRLREGTCVNLSLTTLGNVISALAEAAMGKKV---LHIPYRDSVLTKLLQS 354

  Fly   316 NLGGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSM 380
            .|||||||||:|.|||:...|||||||||||:|||:|.|.|::|..|..|:|:||:.|...|.|.
 Frog   355 ALGGNSRTVMIAAISPADICYEETLSTLRYAERAKKIKNKAIINAGPTERLIKELKAENNKLLSR 419

  Fly   381 LKHATGSPVGDVQ-DKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQASGIKVEK 444
            |.....|  |..| ....|:|..::.:..|||.:|   :..:.|.:|         |.:.|..|:
 Frog   420 LAGLGNS--GKRQLSGCYENELRIQTMQITWEHQL---QEARKEWEQ---------QYAAITQER 470

  Fly   445 NKY----YLVNLNADPSLNELLVYYLKDRTLIGGRTISGQQPD--IQLSGLGIQPEHCVITIEDS 503
            ...    ||:|:|.||.|:.:|.:::::     |.:..||.|.  |.|.||||.|:|......:|
 Frog   471 RMMQLYPYLLNINEDPQLSGVLKHFIQE-----GASDVGQDPSNVITLRGLGILPQHATFINSES 530

  Fly   504 GLYMEPVQGARCFVNGSAAVEKTPLQNGDRILWG-NHHFFRVNSPKSNN-TSMCASEPQTPAQLI 566
            .::::|....:..|||...|..|.||:.|||:.| |..:..:..|.... ..:|.         .
 Frog   531 KVFVKPHGKGKVIVNGVPIVLNTKLQHLDRIILGSNSAYLYIGFPAERGPDDLCR---------F 586

  Fly   567 DYNFARDEIMQNELSNDPIQTAIARLERQHEEDKQVALEKQRQEYERQFQQLRNILSPSTPYAPY 631
            ||:|.:.|:...|      ..::..|...|.::
 Frog   587 DYDFFQSELAAAE------GFSVDTLGPVHNKE-------------------------------- 613

  Fly   632 APYDPLRMGKITPNTPTSQMRVEKWAQERDEMFRRSLGQLKTDIMRANSLVQEANFLAEEMEKKT 696
                    ||..|                      |:..:..|.::...||.|||.::||:.|..
 Frog   614 --------GKPDP----------------------SVLAVFHDFIKLMPLVAEANQMSEELSKDL 648

  Fly   697 KFSVTLQIPPANLSPNRRRGAFVSEPAILVKRTNSGSQ---IWTMEKLENKLIDMREMYQEHKER 758
            ||.:.::    ||:....|| :..:..|.||..|..:.   ||:..|..|:...|.|:||    |
 Frog   649 KFELKVK----NLALTDSRG-YDLQKEISVKVINQITNQVWIWSKSKFINRKFLMEELYQ----R 704

  Fly   759 VLNGLDEDNAKPQDPFYESQENHNLIGVANIFLEVLFHDVKLDYHTPIISQQGEVAGRLQVEIER 823
            .|:|.|....:..|||::..|..:| |.|:|:|:.|.:.:||:..|.:::.:|.....|.:.|
 Frog   705 YLDGGDISLDRESDPFWDPVEVIHL-GSAHIWLQSLAYCMKLEEQTELLNSEGVEEAILVINI-- 766

  Fly   824 IAGQMPQDRMCESVSESSGDSRDEYDDPVDPTSNQITCRVTI-KCAS----------GLPLSLSN 877
                    ..|.......|: .|...||::....:|..::.| :|..          |:.:....
 Frog   767 --------TPCSDTERPFGE-EDIVIDPLELLGRKIEFQIHILQCLGVRWLKEATNRGIQIGYHF 822

  Fly   878 FVFCQ--YT--FWGHQEMVVPVINAESTAHDQNMVFKFEHTQDF-TVTINEEFLEHCIEGALSIE 937
            :..||  ||  .|   :.|.|:|               :|...| .:.::...|.:..:.||.::
 Frog   823 YDVCQCVYTKPVW---KNVNPII---------------DHKLQFVALNVSNVLLSYLQKHALVVD 869

  Fly   938 VWG 940
            :||
 Frog   870 LWG 872

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	183/367 (50%)
		Kinesin_assoc	356..468	CDD:465047	33/116 (28%)
		FHA_KIF13	446..547	CDD:438758	34/107 (32%)
		KIF1B	741..786	CDD:463574	14/44 (32%)
		DUF3694	989..1243	CDD:463599
		CAP_GLY	1785..1850	CDD:460154
kif28	XP_031758561.1	Motor_domain	42..398	CDD:473979	183/367 (50%)
		FHA_KIF28P	477..574	CDD:438761	34/101 (34%)
		KIF1B	691..725	CDD:463574	12/37 (32%)