Protein Alignment Khc-73 and stard9

DIOPT Version :10

• Sequence 1: NP_001261000.1
• Gene: Khc-73 / 36718
• FlyBaseID: FBgn0019968
• Length: 1957
• Species: Drosophila melanogaster
• Sequence 2: XP_012824730.2
• Gene: stard9 / 100489699
• XenbaseID: XB-GENE-995220
• Length: 3979
• Species: Xenopus tropicalis
• Alignment Length: 2277
• Identity: 524/2277 - (23%)
• Similarity: 875/2277 - (38%)
• Gaps: 626/2277 - (27%)

  Fly     6 IKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIE-----RKQPKTFAFDHCFYSLNP 65
            ::||:||||.::||.....:.|:.::.:...::|.....|.:     |::...|.||.|::|::|
 Frog     4 VRVALRVRPPSKRETAEGARIILNVDDKVARIKNIRLDHKSDGCGDVRERLMEFGFDSCYWSVDP 68

  Fly    66 EDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCDQLFSA 130
            ||..:||||.||..:|..:|..|..|||.|:||||||||||:||||||..|.|:.||:|:.|||
 Frog    69 EDPKYASQEVVFQDLGTLVLSEAISGYNVCLFAYGQTGSGKTYTMMGTPASIGLTPRICEGLFS- 132

  Fly   131 IANKSTPEL--MYKVEVSYMEIYNEKVHDLLDPKPNKQ--SLKVREHNVMGPYVDGLSQLAVTSY 191
             .::.:||.  ..:.|||::|||||:|.|||.....|:  :|:||||...||||.||||..||||
 Frog   133 -YDEGSPEAPNSCRTEVSFLEIYNERVRDLLHKSEQKKPYTLRVREHPERGPYVQGLSQHVVTSY 196

  Fly   192 QDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSER 256
            :.:..|:.||.::|..|||:::..||||||:|::..||.:.:.  .:..|..|:::|||||||||
 Frog   197 EQVVALLEEGMENRITAATHIHDASSRSHAIFTIQYTQAMLED--NLPTEITSKINLVDLAGSER 259

  Fly   257 AVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQS-----------------------------N 292
            | ......|||.||||||:||.|||:|||.||..|                             |
 Frog   260 A-SPEYCKDRLTEGSNINRSLVTLGIVISTLAQNSQMTSSCQSINSIASDGDSGSQGSPSGGSMN 323

  Fly   293 GKKSGNDKFVPYRDSVLTWLLKDNLGGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAV 357
            |.|  ...:||||||:|||||||:|||||:|:|:||:||::.:|.||:||||||..||.|||...
 Frog   324 GSK--RQPYVPYRDSILTWLLKDSLGGNSKTIMIATVSPASSSYNETMSTLRYASHAKNIVNKPR 386

  Fly   358 VNEDPNARIIRELRHEVETLRSMLKH---ATGSPV------GDVQDKLAESENLMKQISQTWEEK 413
            ||||.|.::||:||.|:..|::||:.   .|.||.      |:..:.:.::|..::|:::.|.||
 Frog   387 VNEDANVKLIRDLREEINRLKNMLQSFEIRTISPSFSDEKDGNFTELVKQNELKIEQLTKDWTEK 451

  Fly   414 LVKTERIQNERQQALEKMGISVQ--ASGIKVEKNKYYLVNLNADPSLNELLVYYLKDRTLIGGRT 476
                   ..::...:|:..:.:.  .:|:.::.|..:|:.::.|.....:::|.||:.....||.
 Frog   452 -------WGDKAAIMEQYNVDINQGKAGLTIDSNLPHLITMDDDILSTRVVIYQLKEGQTNIGRF 509

  Fly   477 ISGQQPDIQLSGLGIQPEHCVITIEDSGLYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHF 541
            .|.|:.||.|.|..|:.:||:|......:.::||.||:|.:||........|..||.::.|..|.
 Frog   510 DSEQEQDIVLQGEWIERDHCMIHNCSGAVELQPVPGAQCTINGQEVTGSCRLSQGDVLIIGKTHR 574

  Fly   542 FRVNSP----------KSNNTSMCASEPQTPAQLIDY-----NFARDE-----IMQNELSNDPIQ 586
            ||.|:|          ..:..|..:|..      :|:     ||:...     |:..:|.::..|
 Frog   575 FRFNNPAEAAVLRQRRSDSQVSFVSSNS------LDWLDLSGNFSTSTNENPLILNRKLESEEYQ 633

  Fly   587 TAIARLERQHEEDKQVALEKQRQEY----ERQFQQLRNILSPSTPYAPYAPYDPLRMGKITPNTP 647
            ..:..||..:::..|     |:|.|    ::|.|
 Frog   634 QKLKDLEGYYQQQVQ-----QQQLYVEDLKKQIQ------------------------------- 662

  Fly   648 TSQMRVEKWAQERDEMFRRSLGQLKTDIMRANSLVQE-ANFLAEEMEKKTKFSVTLQIPPANLSP 711
            ||::|.||              :|:.:....|.:::| ..:|.:|.::.||..:..:...|...|
 Frog   663 TSKIRSEK--------------ELELEQSLINQIIEENRQWLVKEEQQLTKSHLQRRDSSAQTDP 713

  Fly   712 NRRRGAFVSEPAILVKRTNSGSQIWTMEKLENKLIDMREMYQE----------HKERVLNGLDED 766
            .....|.|...|....|.::.       :|:.|.:..||:.::          .::|:...| |.
 Frog   714 KPIAEAEVQNTAETENRPSAA-------ELDRKRLVQRELLRKCSLRRAERNIRRKRIKFQL-ER 770

  Fly   767 NAKPQDPFYESQENHNLIGVANIFLEVLFHDVKLDYHTPIISQQGEVAGRLQVEIERIAGQMPQD 831
            ..|.|......:|..:|..|..|..:.:.....||...|...........|....:.:.......
 Frog   771 IIKKQKLLEAKKELQHLQAVCWISEDTVKQLQNLDSDGPAKGLTHFRPSALPRSFQTLPNLSILK 835

  Fly   832 RMCE-SVSESSGDSRDEYDDPVDPTSNQITCRVTIKCASGLPLSLSNFVFCQYTFWGHQEMVVPV 895
            |.|| :||..|....:| ..|....|  :.| ::..|.|||
 Frog   836 RNCEPAVSLHSNKPSNE-KKPRRAVS--VEC-LSSTCCSGL------------------------ 872

  Fly   896 INAESTAHDQNMVFKFEHTQDFTVTINEEFLEHCIEGALSIEVWGHRSAGFSKTKGWEVEQQQAK 960
              ...|.:|...:.:....:.|....|:.          ....:|.....::         |.:|
 Frog   873 --QSETPNDHQCIVQGVEKRPFGSITNQN----------KQSTYGKFVCAYT---------QMSK 916

  Fly   961 ARSLVDRWAELSRKIELWVEIHELNDNGEYSPVEVTNRNEVLTGGIYQLRQGQQRRVNVRVKPVQ 1025
            .|..:|:....|:.    .....|.......|:..||.                   :.:||..:
 Frog   917 KRQKMDKTGSRSKS----KTTEPLKRRNSRIPIATTNS-------------------DTKVKSFR 958

  Fly  1026 NSGTLPIICQSIVNVAIGSVTVRSRLQRPLDSYQEEDLTVLREKWS---------EALGRRRQYL 1081
            :|..     ||:.:..      :|.||...::.::.:.||.:...|         :..||....|
 Frog   959 SSPQ-----QSLESCR------KSTLQENKNTLEKNEATVKKNTKSIPKTITSGKKTAGRSTSTL 1012

  Fly  1082 DQQIQMLIKKEEKNEQERERELSL----------VHQWVSLTEERNAVLVPAPGSGIPGAPASWE 1136
                         ...:|:.:|.|          :.:..|.|:..|.:..|.|...|.....|.|
 Frog  1013 -------------KASKRDADLCLKNINKKPANGLAKICSSTDSINTLSRPTPTHAIDKRWQSTE 1064

  Fly  1137 PPS-GMEPHVPVLFLNLNGDDLSAQNTN------DELSVAGINSILSKEHGHKFYTLQILQHLDK 1194
            ..| |:.....|||.:...:|.:..:.:      |.||.| ..|.|:|:...|...:       |
 Frog  1065 RLSRGLLKPKEVLFEDCKEEDETGSSESESFYSVDSLSSA-FGSALTKDLNWKKLAI-------K 1121

  Fly  1195 DVCC---VASWDSSMHDSQALNRVT---EANERVYLILRTTV--------RLSHPAPMDLVLRKR 1245
            :|.|   ..|.||.|.......|.|   :.|.|.:...:|.:        .:..|.|:.||:...
 Frog  1122 NVACKNNSDSEDSEMSQDSLAERGTKREKPNRRRFNNYKTVLTPCSSSKDMVEDPNPLPLVMGTS 1186

  Fly  1246 LSINIKKGQTLTDRLKKFRLVRGENA-------------IWQ------SGVTYEVVSNIPKASEE 1291
            ::..:.|..:|..      |...|:.             .|:      ||:..|..:||.....|
 Frog  1187 ITTGLSKSFSLDS------LADAEDVPEMDSSEEMPAEIFWKLQSPRISGLQTEDQNNISSTEAE 1245

  Fly  1292 ---------------------------LEDRESL---AQ------------------LAAS---- 1304
                                       |.:|:.:   ||                  ||||
 Frog  1246 NSSDKGLSNSFYLNVNPLFALDCSDAVLSNRDGINPQAQTNMDDVVSGELENSCPPDLAASALWE 1310

  Fly  1305 GDDCSAS------DGETYIEKYTRGVSAVESILTLDRLRQNVAVKELETAHGQPLSMRKTVSVPN 1363
            ..||:.:      :|.|.|.:    ......:.|...::.|....|     |.....|..:.:||
 Frog  1311 SQDCTITSANNKCEGSTIISE----TELPNQVSTKYSIKNNQCPVE-----GTVKGSRVNLPLPN 1366

  Fly  1364 FSQIMRFDASMESLLNVGRSESFADLNNSALGNKFTPAGHSPAGAGGVIRSRHSFGGK-----GS 1423
              :.:..:.:.....|..| ||...:.::|..:.|....:.     |.::.:...|.|     ..
 Frog  1367 --ENVEPETTAPECTNEQR-ESNCQILDAAANSDFKDLQYL-----GPLKDQLKAGEKVVLKCSV 1423

  Fly  1424 SDDS-----PGKAFGI----------ASPATSKLLG----------MRMTTLHEEPLGGHRSLDE 1463
            .|:|     |....|:          .:|.|.||.|          :::||::.:.......|..
 Frog  1424 KDESRALKDPDICIGLPTANHEDTSGPTPGTGKLKGGIVKEILPTRLKITTVNAKKSPNKMKLTR 1488

  Fly  1464 EPEDSYSDSEYAAEYEQERQQNKSMATRSRLTASKTMDSFMDVSSHSNQSYLSYTSSANAN---- 1524
            : ||:   .|...:.:|.......:....:.....:..||.......:.::.:|.::...:
 Frog  1489 K-EDT---KEIRLQMKQSNDLTPDVICNQKEKCEPSTLSFHVTQGSGDTNHYNYHTTEGTSDQQD 1549

  Fly  1525 ---------------MKHLTGLATLSMSSSTSSGYGSQAVSCNNLSNEDIASMRSMSIDETPDFD 1574
                           :||:..|..|.          :.||| |.|..||:.|:.::.::.:|...
 Frog  1550 KYDTEVAKPMPNCEQLKHIDSLEPLF----------NPAVS-NVLEVEDLDSLENLKMELSPQIS 1603

  Fly  1575 RVNSNSPPNRQARVNPFLKDMPKAKIQEQPEQQAKKLQEAF-THPLEQLESSQNAQS------DD 1632
             |:.|                 |.:...:|.:..|.:..:| |.|..:|:.:.|.::      ::
 Frog  1604 -VDGN-----------------KLEKPAEPCELQKLIPSSFYTSPHIELDLNANEENCKKCGIEN 1650

  Fly  1633 DECAQLPKNNNNNL----DLVNEPKPLSSQTDLEESMSQPKSKTEFATD------NQNGNRSSDE 1687
            |||       :|.:    :.:||   .|..|.:|:.|..|.:.:.|..:      .:..:.:.::
 Frog  1651 DEC-------DNGITEGREYLNE---RSGSTRVEDIMMVPDNHSHFNVNPCVDKCRKQPSLAQEK 1705

  Fly  1688 LSHSSEDLL-------------EGDGIVREELPAGKVVRRKKSNT----QPPS------------ 1723
            ::..:.||.             :|.|...|.:  |.|.:..:.||    :|.|
 Frog  1706 ITPIASDLALDVKIKRNDLETGQGSGFTEEAM--GSVQQNMEDNTPRLHEPKSTNTLLLTNSRDL 1768

  Fly  1724 --NGNSINNNNNGTT---------QAPRINHRASVAKMEGLAAYLDSSIMTSSTEVDEESKDVEL 1777
              |...:.|::|..|         ::.:.....|...:|....:...|...||..::......|.
 Frog  1769 TFNPTKLANDSNFITNVNLKDAKKESDKAGDGVSFVSVESDHCFTIPSPAASSDTLNSNVSGTET 1833

  Fly  1778 VLPEWIVVGESVLIRPYNTSGVIRFVGTT---EFQPGAWIGVELDTPTGKNDGSVKGVQYFQCKP 1839
            |.|.....|:..::. .:||...:..|::   .|..||.|.|         |.::
 Frog  1834 VSPALTDSGQKTVMF-QSTSSFTKSTGSSLLPSFNEGACIQV---------DNNI---------- 1878

  Fly  1840 KHGMFVRSDKLML--------DKRGKAMRAYKAAEKSNSISKEMSTSMTG--------------- 1881
            |...|.:||..||        ::|.:.|.. :|..|. .:|:|:...:|.
 Frog  1879 KDNTFRQSDADMLSLVENISKERRERVMDG-EAVTKP-KLSEEIMLQVTNEQVNLLAPVKNHCSV 1941

  Fly  1882 --SMTRSKSRGDSLNLSARKXLYPKCSHQLQRWTNCRQSTVATSSQP---ATCHRLRATSGAADA 1941
              .||.||:....|.....|..:               |..|.:..|   ..|..::...|.||:
 Frog  1942 PEQMTGSKNEDCELKGKNEKEKF---------------SVDAQTESPLEKMACSTIKGAVGMADS 1991

  Fly  1942 NS 1943
            .|
 Frog  1992 MS 1993

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	178/390 (46%)
		Kinesin_assoc	356..468	CDD:465047	29/122 (24%)
		FHA_KIF13	446..547	CDD:438758	32/100 (32%)
		KIF1B	741..786	CDD:463574	11/54 (20%)
		DUF3694	989..1243	CDD:463599	58/293 (20%)
		CAP_GLY	1785..1850	CDD:460154	14/67 (21%)
stard9	XP_012824730.2	KISc_KIF1A_KIF1B	2..388	CDD:276816	178/390 (46%)
		FHA_KIF16A_STARD9	472..590	CDD:438783	35/117 (30%)
		SRPBCC	3775..3977	CDD:472699