DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc-73 and kif1b

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	XP_012822406.1	Gene:	kif1b / 100379810	XenbaseID:	XB-GENE-1013591	Length:	1810	Species:	Xenopus tropicalis

Alignment Length:	2040	Identity:	562/2040 - (27%)
Similarity:	840/2040 - (41%)	Gaps:	677/2040 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYSLNP 65
            |:...:||||||||||.||:..::|||::|:...|.:.||    |..::..|:|:||:.::|...
Frog     1 MSGASVKVAVRVRPFNSRELSKESKCIIQMQGNSTSIINP----KNPKEAAKSFSFDYSYWSHTS 61

  Fly    66 EDEN-FASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQE--SKGIIPRLCDQL 127
            :|:. ||||..|::.:|:.:|::||:|||.|||||||||:||||||||.||  ..||||:||:.|
Frog    62 QDDPCFASQSRVYNDIGKEMLEHAFEGYNVCIFAYGQTGAGKSYTMMGKQEETQAGIIPQLCEDL 126

  Fly   128 FSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQ 192
            |..|.:.:..|:.:.|||||||||.|:|.|||:|| ||.:|:||||.::||||:.||:||||||.
Frog   127 FEKINDNNNDEVSFSVEVSYMEIYCERVRDLLNPK-NKGNLRVREHPLLGPYVEDLSKLAVTSYT 190

  Fly   193 DIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSERA 257
            ||.:||..|||:|||||||||..||||||||::|.||...|..|.:|.||||::|||||||||||
Frog   191 DIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKRLDIGTNLSTEKVSKISLVDLAGSERA 255

  Fly   258 VKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSN----GKKSGNDKFVPYRDSVLTWLLKDNLG 318
            ..|||.|.|||||:||||||||||.|||.||:..|    .||.....|:|||||||||||::|||
Frog   256 DSTGAKGTRLKEGANINKSLTTLGKVISALAEVDNCTSKSKKKKKTDFIPYRDSVLTWLLRENLG 320

  Fly   319 GNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSMLKH 383
            |||||.|||.:||:..||:|||||||||||||:|..:||:||||||:::|||:.||..|:.:|:
Frog   321 GNSRTAMVAALSPADINYDETLSTLRYADRAKQIKCNAVINEDPNAKLVRELKDEVTRLKDLLR- 384

  Fly   384 ATG-------------SPVGDVQD----------------------------------------- 394
            |.|             .|:.|:.|
Frog   385 AQGLGDILDTLPSVGCFPISDMNDNENLKNKYLLANENQRPGNFSTASISSLASSPSSCSLSSQV 449

  Fly   395 -----------------------KLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQ 436
                                   :|.|||.::.::::||||||.|||.|:.:|:..|.:||::::
Frog   450 GLTSVTSIQERIMSTPGGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMDREALLAEMGVAIR 514

  Fly   437 AS----GIKVEKNKYYLVNLNADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCV 497
            ..    |:...|...:|||||.||.::|.|:||:||.....|:..:..:.||.|||..|:.|||:
Frog   515 EDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGLTRVGQADADSRQDIVLSGAHIKEEHCI 579

  Fly   498 ITIEDSG-----LYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNTSM-CA 556
            ...|.:.     :.:||...:..:|||...|....|::|:||:.|.:|.||.|.|:...... ..
Frog   580 FRSERNSNGEVIVTLEPGDRSETYVNGKRVVHPVELRSGNRIIMGKNHVFRFNHPEQARAEREKT 644

  Fly   557 SEPQTPAQLIDYNFARDEIMQNELSNDPIQTAIARLE------RQHEEDKQVALEKQRQEYERQF 615
            ...:||::.:|:.||:.|:::.: ..|..|....||:      ::.:|:..:.||:||.:||.:.
Frog   645 PSAETPSEPVDWTFAQRELLEKQ-GIDMKQEMEKRLQEMEILYKKEKEEADLLLEQQRLDYESKL 708

  Fly   616 QQLR------NILSPST----------PYAPYAPYDPLRMGKITPNTPTSQMRVEKWAQERDEMF 664
            |.|:      ::.:.:|          |:..: .||            .:....:||...:....
Frog   709 QALQKQVETHSLAAETTDDGEEEEEEVPWTQH-EYD------------VALWAFKKWRNHQFTSL 760

  Fly   665 RRSLGQLKTDIMRANSL-VQEANFLAEEMEKKTKFSVTL-------QIPPANLSPNRRRGAFVSE 721
            |        |::..|:: ::|||.::.|::||.:|...|       .:||..|
Frog   761 R--------DLLWGNAMYLKEANAISVELKKKVQFQFVLLTDTLYSPLPPELL------------ 805

  Fly   722 PAILVKRT------------------NSGSQIWTMEKLENKLIDMREMY----------QEHKER 758
            |:...|.|                  |..:..|::|||..:|..|||||          |:..:.
Frog   806 PSDADKTTEDRTFPRTVVAVEVQDLKNGATHYWSLEKLRLRLEQMREMYDRAGEMASHVQDENDT 870

  Fly   759 VLNGLD---------------------------------------------EDNAKPQ------- 771
            |:.|.|                                             .|..:.|
Frog   871 VITGNDPFYDRFHWFKLVGSSPIFHGCVNERLADRTPSPTFSTADSDITELADEQQDQMEDFDDE 935

  Fly   772 -----------------------DPFYESQENHNLIGVANIFLEVLFHDVKLDYHTPIISQQGEV 813
                                   ||||:......|:|.|.::|..|...|.|.:...|:|::|||
Frog   936 PFVDDTGSDVGAEEGSDLFSDGHDPFYDRSPWFILVGRAFVYLSNLLFPVPLVHRAAIVSEKGEV 1000

  Fly   814 AGRLQVEIERIAG-----------------------------------------QMPQDRMCESV 837
            .|.|:|.::.|:|                                         .:.:.|:.|..
Frog  1001 RGFLRVAVQAISGDEEAPDYGSGIRQSGTAKISFDNEYINKNEISSMVLTRSGLSLEELRIVEGQ 1065

  Fly   838 SESSG-DSRDEYDDPVD--------------------------PTSNQITCRVTIKCASGLPLSL 875
            .::|. .|.:|.:...|                          ...:..|.|||:..|||:|...
Frog  1066 GQNSDITSLEEVNHLADLDLKSGNLLDGKMMMEGFSEDVGEHLKIGSMFTFRVTVLQASGIPPEY 1130

  Fly   876 SNFVFCQYTF-WGHQE--MVVPVINAESTAHDQNMVFKFEHTQDFTVTINEEFLEHCIEGALSIE 937
            :: :|||:.| ..|.|  ...|:.|:     .:.....|.|.|:..|.|.|.|:|:.....:..|
Frog  1131 AD-IFCQFNFLHRHDEAFSTEPLKNS-----GRGNPLGFYHVQNIAVEITESFIEYIKNNPIVFE 1189

  Fly   938 VWGHRSAGFSKTKGWEVEQQQAKARSL-----------VDRWAELSRK----------IELWVEI 981
            |:||........:|.::...|...|..           ..:...||::          :.:|.||
Frog  1190 VFGHYQQHPLHLQGQDLSPPQQCRRYFPPPMPLSKPVPATKLNPLSKQSLGQVISKYDLLVWFEI 1254

  Fly   982 HELNDNGEYSPVEVTNRNEVLTGGIYQLRQGQQRRVNVRVKPVQNSGTLPIICQSIVNVAIGSVT 1046
            .||...|||.|..|.:...:...|.:.|.||.|||:.|
Frog  1255 SELEPTGEYIPAVVDHSGGLPCQGTFLLHQGIQRRITV--------------------------- 1292

  Fly  1047 VRSRLQRPLDSYQEEDLTVLREKWSE---------ALGRRRQYLDQQIQMLIKKEEKNEQERERE 1102
                             |::.||.:|         .:||.|...|:
Frog  1293 -----------------TIVHEKGNELHWKDVRELVVGRVRNKADE------------------- 1321

  Fly  1103 LSLVHQWVSLTEERNAVLVPAPGSGIPGAPASWEPPSGMEPHVPVLFLNLNGDDLSAQNTNDELS 1167
                                        |.|.           .||.||:             :|
Frog  1322 ----------------------------AAAD-----------AVLSLNI-------------IS 1334

  Fly  1168 VAGINSILSKEHGHKFYTLQILQHLDKDVCCVASWDSSMHDSQALNRVTEANERVYLILRTTVRL 1232
            ...:.|  |...|..||..:            |.||||:|:|..|||||...|::|:.|...:.|
Frog  1335 AKYLRS--SHSSGRTFYRFE------------AVWDSSLHNSLLLNRVTPYGEKIYMTLSAYLEL 1385

  Fly  1233 SH---PAPMDLVLRKRLSINIKKGQTLTDRLKKFRLVRGENAIWQSGVTYEVVSNIPKASEELED 1294
            .|   ||    |:.|.:.:      ....|..|....|...:::.||.:.....|......||
Frog  1386 DHCIQPA----VITKDVCM------IFYSRDAKISPPRSLRSLFGSGYSKSPDCNRVTGIYEL-- 1438

  Fly  1295 RESLAQLAASGD-----------DCSASDGETYIEKYTRGVSAVESILTLDRLRQNVAVKELETA 1348
              ||.::|.:|.           |.|.:        |.||    |..|...|.|.:..:.|
Frog  1439 --SLCKMADTGSPGMQRRRRKILDTSVA--------YVRG----EENLAGWRPRGDSLILE---- 1485

  Fly  1349 HGQPLSMRKTVSVPNFSQIMRFDASMESLLNVGRSESFADLNNSALGNKFTPAGHSPAGAGGVIR 1413
            |...|.                  .||.|..|.::.....|.:. ||:...
Frog  1486 HQWELE------------------KMEQLHEVEKTRHLLLLRDK-LGDSIP-------------- 1517

  Fly  1414 SRHSFGGKGSSDD-SPGKAFGIASPATSKLLGMRMTTLHEEPL-----GGHRSLDEEPEDSYSDS 1472
                   |..|:. ||..:.|..|.:|| :.....||..|..:     .|:.|.|.|   |..|.
Frog  1518 -------KSLSESISPSLSSGTLSTSTS-ISSQISTTTFESAITPSESSGYDSTDVE---SLVDR 1571

  Fly  1473 EYAAEYEQERQQNKSMATRSRLTASKTMDSFMDVSSHSNQSYLSYTSSANANMKHLTGLATLSMS 1537
            |            |.:||:.           :.:.:|:....|:...::.::.| |:.::.:...
Frog  1572 E------------KELATKC-----------LRLLTHTFNQELTQVCNSISDCK-LSDISPIGRD 1612

  Fly  1538 SSTSSGYGSQAVSCNNLSNEDIASMRSMSIDE-TPDFDRVNSNSPPNR----------------Q 1585
            .|.||  .|.|....:.:...:|..|..|:|: ||:.:. .::||...                :
Frog  1613 PSVSS--FSSATLTPSSTCPSLADSRCSSVDQKTPEANS-RASSPCTEFEQFHLVPAVERSFLAR 1674

  Fly  1586 ARVNPFLKDMPKAKIQE-QPEQQAKK-----LQEAFTH----------------------PLEQ- 1621
            |..|.||..:|  .|:| :|.....|     .:|..:|                      |:|:
Frog  1675 AGKNEFLNLVP--DIEEIRPGSVVSKKGYLNFKEPLSHSWVKHFVVVRRPYVFIYNSDKDPVERG 1737

  Fly  1622 ---LESSQNAQSDDDECAQLPKNNN 1643
               |.::|...|:|.:.  :.|::|
Frog  1738 LINLSTAQVEYSEDQQA--MVKSSN 1760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	217/361 (60%)
		KISc	6..359	CDD:214526	217/359 (60%)
		Kinesin_assoc	356..468	CDD:292801	51/192 (27%)
		FHA	446..546	CDD:238017	38/104 (37%)
		KIF1B	741..786	CDD:289208	18/129 (14%)
		DUF3694	<1196..1252	CDD:289256	21/58 (36%)
		CAP_GLY	1786..1850	CDD:279625
kif1b	XP_012822406.1	KISc_KIF1A_KIF1B	4..361	CDD:276816	217/361 (60%)
		Kinesin_assoc	358..552	CDD:374417	53/194 (27%)
		FHA	529..633	CDD:238017	38/103 (37%)
		Prefoldin	659..714	CDD:385414	15/55 (27%)
		KIF1B	843..890	CDD:372100	11/46 (24%)
		KIF1B	<954..972	CDD:372100	5/17 (29%)
		DUF3694	1262..1407	CDD:372133	54/283 (19%)
		PH_KIFIA_KIFIB	1691..1793	CDD:269939	12/72 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010