Protein Alignment Khc-73 and kif1b

DIOPT Version :10

• Sequence 1: NP_001261000.1
• Gene: Khc-73 / 36718
• FlyBaseID: FBgn0019968
• Length: 1957
• Species: Drosophila melanogaster
• Sequence 2: XP_012822406.1
• Gene: kif1b / 100379810
• XenbaseID: XB-GENE-1013591
• Length: 1810
• Species: Xenopus tropicalis
• Alignment Length: 2040
• Identity: 562/2040 - (27%)
• Similarity: 840/2040 - (41%)
• Gaps: 677/2040 - (33%)

  Fly     1 MASDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYSLNP 65
            |:...:||||||||||.||:..::|||::|:...|.:.||    |..::..|:|:||:.::|...
 Frog     1 MSGASVKVAVRVRPFNSRELSKESKCIIQMQGNSTSIINP----KNPKEAAKSFSFDYSYWSHTS 61

  Fly    66 EDEN-FASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQE--SKGIIPRLCDQL 127
            :|:. ||||..|::.:|:.:|::||:|||.|||||||||:||||||||.||  ..||||:||:.|
 Frog    62 QDDPCFASQSRVYNDIGKEMLEHAFEGYNVCIFAYGQTGAGKSYTMMGKQEETQAGIIPQLCEDL 126

  Fly   128 FSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQ 192
            |..|.:.:..|:.:.|||||||||.|:|.|||:|| ||.:|:||||.::||||:.||:||||||.
 Frog   127 FEKINDNNNDEVSFSVEVSYMEIYCERVRDLLNPK-NKGNLRVREHPLLGPYVEDLSKLAVTSYT 190

  Fly   193 DIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSERA 257
            ||.:||..|||:|||||||||..||||||||::|.||...|..|.:|.||||::|||||||||||
 Frog   191 DIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKRLDIGTNLSTEKVSKISLVDLAGSERA 255

  Fly   258 VKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSN----GKKSGNDKFVPYRDSVLTWLLKDNLG 318
            ..|||.|.|||||:||||||||||.|||.||:..|    .||.....|:|||||||||||::|||
 Frog   256 DSTGAKGTRLKEGANINKSLTTLGKVISALAEVDNCTSKSKKKKKTDFIPYRDSVLTWLLRENLG 320

  Fly   319 GNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSMLKH 383
            |||||.|||.:||:..||:|||||||||||||:|..:||:||||||:::|||:.||..|:.:|:
 Frog   321 GNSRTAMVAALSPADINYDETLSTLRYADRAKQIKCNAVINEDPNAKLVRELKDEVTRLKDLLR- 384

  Fly   384 ATG-------------SPVGDVQD----------------------------------------- 394
            |.|             .|:.|:.|
 Frog   385 AQGLGDILDTLPSVGCFPISDMNDNENLKNKYLLANENQRPGNFSTASISSLASSPSSCSLSSQV 449

  Fly   395 -----------------------KLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQ 436
                                   :|.|||.::.::::||||||.|||.|:.:|:..|.:||::::
 Frog   450 GLTSVTSIQERIMSTPGGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMDREALLAEMGVAIR 514

  Fly   437 AS----GIKVEKNKYYLVNLNADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCV 497
            ..    |:...|...:|||||.||.::|.|:||:||.....|:..:..:.||.|||..|:.|||:
 Frog   515 EDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGLTRVGQADADSRQDIVLSGAHIKEEHCI 579

  Fly   498 ITIEDSG-----LYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNTSM-CA 556
            ...|.:.     :.:||...:..:|||...|....|::|:||:.|.:|.||.|.|:...... ..
 Frog   580 FRSERNSNGEVIVTLEPGDRSETYVNGKRVVHPVELRSGNRIIMGKNHVFRFNHPEQARAEREKT 644

  Fly   557 SEPQTPAQLIDYNFARDEIMQNELSNDPIQTAIARLE------RQHEEDKQVALEKQRQEYERQF 615
            ...:||::.:|:.||:.|:::.: ..|..|....||:      ::.:|:..:.||:||.:||.:.
 Frog   645 PSAETPSEPVDWTFAQRELLEKQ-GIDMKQEMEKRLQEMEILYKKEKEEADLLLEQQRLDYESKL 708

  Fly   616 QQLR------NILSPST----------PYAPYAPYDPLRMGKITPNTPTSQMRVEKWAQERDEMF 664
            |.|:      ::.:.:|          |:..: .||            .:....:||...:....
 Frog   709 QALQKQVETHSLAAETTDDGEEEEEEVPWTQH-EYD------------VALWAFKKWRNHQFTSL 760

  Fly   665 RRSLGQLKTDIMRANSL-VQEANFLAEEMEKKTKFSVTL-------QIPPANLSPNRRRGAFVSE 721
            |        |::..|:: ::|||.::.|::||.:|...|       .:||..|
 Frog   761 R--------DLLWGNAMYLKEANAISVELKKKVQFQFVLLTDTLYSPLPPELL------------ 805

  Fly   722 PAILVKRT------------------NSGSQIWTMEKLENKLIDMREMY----------QEHKER 758
            |:...|.|                  |..:..|::|||..:|..|||||          |:..:.
 Frog   806 PSDADKTTEDRTFPRTVVAVEVQDLKNGATHYWSLEKLRLRLEQMREMYDRAGEMASHVQDENDT 870

  Fly   759 VLNGLD---------------------------------------------EDNAKPQ------- 771
            |:.|.|                                             .|..:.|
 Frog   871 VITGNDPFYDRFHWFKLVGSSPIFHGCVNERLADRTPSPTFSTADSDITELADEQQDQMEDFDDE 935

  Fly   772 -----------------------DPFYESQENHNLIGVANIFLEVLFHDVKLDYHTPIISQQGEV 813
                                   ||||:......|:|.|.::|..|...|.|.:...|:|::|||
 Frog   936 PFVDDTGSDVGAEEGSDLFSDGHDPFYDRSPWFILVGRAFVYLSNLLFPVPLVHRAAIVSEKGEV 1000

  Fly   814 AGRLQVEIERIAG-----------------------------------------QMPQDRMCESV 837
            .|.|:|.::.|:|                                         .:.:.|:.|..
 Frog  1001 RGFLRVAVQAISGDEEAPDYGSGIRQSGTAKISFDNEYINKNEISSMVLTRSGLSLEELRIVEGQ 1065

  Fly   838 SESSG-DSRDEYDDPVD--------------------------PTSNQITCRVTIKCASGLPLSL 875
            .::|. .|.:|.:...|                          ...:..|.|||:..|||:|...
 Frog  1066 GQNSDITSLEEVNHLADLDLKSGNLLDGKMMMEGFSEDVGEHLKIGSMFTFRVTVLQASGIPPEY 1130

  Fly   876 SNFVFCQYTF-WGHQE--MVVPVINAESTAHDQNMVFKFEHTQDFTVTINEEFLEHCIEGALSIE 937
            :: :|||:.| ..|.|  ...|:.|:     .:.....|.|.|:..|.|.|.|:|:.....:..|
 Frog  1131 AD-IFCQFNFLHRHDEAFSTEPLKNS-----GRGNPLGFYHVQNIAVEITESFIEYIKNNPIVFE 1189

  Fly   938 VWGHRSAGFSKTKGWEVEQQQAKARSL-----------VDRWAELSRK----------IELWVEI 981
            |:||........:|.::...|...|..           ..:...||::          :.:|.||
 Frog  1190 VFGHYQQHPLHLQGQDLSPPQQCRRYFPPPMPLSKPVPATKLNPLSKQSLGQVISKYDLLVWFEI 1254

  Fly   982 HELNDNGEYSPVEVTNRNEVLTGGIYQLRQGQQRRVNVRVKPVQNSGTLPIICQSIVNVAIGSVT 1046
            .||...|||.|..|.:...:...|.:.|.||.|||:.|
 Frog  1255 SELEPTGEYIPAVVDHSGGLPCQGTFLLHQGIQRRITV--------------------------- 1292

  Fly  1047 VRSRLQRPLDSYQEEDLTVLREKWSE---------ALGRRRQYLDQQIQMLIKKEEKNEQERERE 1102
                             |::.||.:|         .:||.|...|:
 Frog  1293 -----------------TIVHEKGNELHWKDVRELVVGRVRNKADE------------------- 1321

  Fly  1103 LSLVHQWVSLTEERNAVLVPAPGSGIPGAPASWEPPSGMEPHVPVLFLNLNGDDLSAQNTNDELS 1167
                                        |.|.           .||.||:             :|
 Frog  1322 ----------------------------AAAD-----------AVLSLNI-------------IS 1334

  Fly  1168 VAGINSILSKEHGHKFYTLQILQHLDKDVCCVASWDSSMHDSQALNRVTEANERVYLILRTTVRL 1232
            ...:.|  |...|..||..:            |.||||:|:|..|||||...|::|:.|...:.|
 Frog  1335 AKYLRS--SHSSGRTFYRFE------------AVWDSSLHNSLLLNRVTPYGEKIYMTLSAYLEL 1385

  Fly  1233 SH---PAPMDLVLRKRLSINIKKGQTLTDRLKKFRLVRGENAIWQSGVTYEVVSNIPKASEELED 1294
            .|   ||    |:.|.:.:      ....|..|....|...:::.||.:.....|......||
 Frog  1386 DHCIQPA----VITKDVCM------IFYSRDAKISPPRSLRSLFGSGYSKSPDCNRVTGIYEL-- 1438

  Fly  1295 RESLAQLAASGD-----------DCSASDGETYIEKYTRGVSAVESILTLDRLRQNVAVKELETA 1348
              ||.::|.:|.           |.|.:        |.||    |..|...|.|.:..:.|
 Frog  1439 --SLCKMADTGSPGMQRRRRKILDTSVA--------YVRG----EENLAGWRPRGDSLILE---- 1485

  Fly  1349 HGQPLSMRKTVSVPNFSQIMRFDASMESLLNVGRSESFADLNNSALGNKFTPAGHSPAGAGGVIR 1413
            |...|.                  .||.|..|.::.....|.:. ||:...
 Frog  1486 HQWELE------------------KMEQLHEVEKTRHLLLLRDK-LGDSIP-------------- 1517

  Fly  1414 SRHSFGGKGSSDD-SPGKAFGIASPATSKLLGMRMTTLHEEPL-----GGHRSLDEEPEDSYSDS 1472
                   |..|:. ||..:.|..|.:|| :.....||..|..:     .|:.|.|.|   |..|.
 Frog  1518 -------KSLSESISPSLSSGTLSTSTS-ISSQISTTTFESAITPSESSGYDSTDVE---SLVDR 1571

  Fly  1473 EYAAEYEQERQQNKSMATRSRLTASKTMDSFMDVSSHSNQSYLSYTSSANANMKHLTGLATLSMS 1537
            |            |.:||:.           :.:.:|:....|:...::.::.| |:.::.:...
 Frog  1572 E------------KELATKC-----------LRLLTHTFNQELTQVCNSISDCK-LSDISPIGRD 1612

  Fly  1538 SSTSSGYGSQAVSCNNLSNEDIASMRSMSIDE-TPDFDRVNSNSPPNR----------------Q 1585
            .|.||  .|.|....:.:...:|..|..|:|: ||:.:. .::||...                :
 Frog  1613 PSVSS--FSSATLTPSSTCPSLADSRCSSVDQKTPEANS-RASSPCTEFEQFHLVPAVERSFLAR 1674

  Fly  1586 ARVNPFLKDMPKAKIQE-QPEQQAKK-----LQEAFTH----------------------PLEQ- 1621
            |..|.||..:|  .|:| :|.....|     .:|..:|                      |:|:
 Frog  1675 AGKNEFLNLVP--DIEEIRPGSVVSKKGYLNFKEPLSHSWVKHFVVVRRPYVFIYNSDKDPVERG 1737

  Fly  1622 ---LESSQNAQSDDDECAQLPKNNN 1643
               |.::|...|:|.:.  :.|::|
 Frog  1738 LINLSTAQVEYSEDQQA--MVKSSN 1760

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	217/361 (60%)
		Kinesin_assoc	356..468	CDD:465047	51/192 (27%)
		FHA_KIF13	446..547	CDD:438758	39/105 (37%)
		KIF1B	741..786	CDD:463574	18/129 (14%)
		DUF3694	989..1243	CDD:463599	52/265 (20%)
		CAP_GLY	1785..1850	CDD:460154
kif1b	XP_012822406.1	KISc_KIF1A_KIF1B	4..361	CDD:276816	217/361 (60%)
		Kinesin_assoc	358..552	CDD:465047	53/194 (27%)
		FHA_KIF1B	527..636	CDD:438779	40/108 (37%)
		GimC	659..>716	CDD:440992	15/57 (26%)
		KIF1B	843..890	CDD:463574	11/46 (24%)
		KIF1B	<954..973	CDD:463574	5/18 (28%)
		DUF3694	1262..1407	CDD:463599	54/283 (19%)
		PH_KIFIA_KIFIB	1691..1793	CDD:269939	12/72 (17%)